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BCA Assay and Lowry Assays | Thermo Fisher Scientific - PH
BCA Assay and Lowry Assays | Thermo Fisher Scientific - PH
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Home›Life Sciences›Protein Biology›Protein Assays and Analysis›Protein Assays›BCA Assay and Lowry AssaysBCA Assay and Lowry AssaysSee Navigation‹Protein AssaysFluorescent Protein Assays
›Class-Specific Protein Quantitation
›Amino Acid Analysis Reagents
›Protein Assay Selection Guide
›BCA Assay and Lowry Assays
›Bradford Assay
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Copper-based total protein quantification
The BCA Protein Assay is a popular method for colorimetric detection and quantitation of total protein. Pierce BCA Protein Assays have a unique advantage over the Coomassie dye–based assays (Bradford)–they are compatible with samples that contain up to 5% surfactants (detergents), and are affected much less by protein compositional differences, providing greater protein-to-protein uniformity.For added ease of use, BCA protein assays with dilution-free protein standards reduces assay setup time by up to 80%. Dilution-Free protein standards are a set of prediluted standards packaged in a multichannel pipette compatible format which allows you to easily transfer a full dilution series to your microplate at once.Selection guide Technical handbookOn this page:Choose the right BCA assay for your sampleBCA assay principlesDilution-Free BCA protein assaysAdvantages of BCA assaysBCA protein assay protocolsRelated content:Bradford assays
Choose the right BCA protein assay for your sample
BCA assaysLowry assaysOrderingDocuments Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.
BCA assay principles
Chemistry of BCA-based protein assaysThe Pierce BCA Protein Assays combines the well-known reduction of Cu2+ to Cu+ by protein in an alkaline medium (also known as the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+) by bicinchoninic acid (BCA).Figure 1. The first step is the chelation of copper with protein in an alkaline environment to form a blue-colored complex. In this reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate.Single amino acids and dipeptides are unaffected in the biuret reaction, but tripeptides and larger polypeptides or proteins will react to produce the light blue-to-violet complex that absorbs light at 540 nm. One cupric ion forms a colored coordination complex with four to six nearby peptides bonds. The intensity of the color produced is proportional to the number of peptide bonds participating in the reaction.Figure 2. In the second step, BCA reagent, a highly sensitive and selective colorimetric detection reagent, reacts with the cuprous cation (Cu+) that was formed in the first step and produces a purple-color.The BCA-copper complex is water-soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The purple color may be measured at any wavelength between 550 and 570 nm with minimal (less than 10%) loss of signal. The signal induced by the BCA reagent is approximately 100 times more sensitive (lower limit of detection) than the signal using the biuret reagent.Pierce Dilution-Free Rapid Gold BCA protein assay uses the same copper reduction method as traditional BCA assay with a unique copper chelator. In the second step of the color development reaction, the Pierce Dilution-Free Rapid Gold BCA chelator reacts with the reduced (cuprous) cation (Cu+) that was formed in step one to produce an intensely gold-colored reaction product. The copper complex exhibits a strong linear absorbance at 480 nm with increasing protein concentrations.
Dilution-free BCA protein assays
Dilution-free BSA protein standards are available separately or as part of other BCA protein assays. Compared to the Bradford Assay or Pierce BCA Protein assay kit, the Dilution-Free Rapid Gold BCA Protein Assay reduces assay setup by up to 80% by eliminating the need to dilute samples and standards. Additionally, it only requires a 5-minute, room temperature incubation. The dilution-free BSA protein standards are also available in the BCA Protein Assay Kit with Dilution-Free BSA Protein Standards.Figure 3. The Pierce Dilution-Free Rapid Gold BCA Assay reduces setup time by up to 80% compared to other protein assays. The assays were conducted following the manufacturer’s protocols in a microplate format. Five cell lysates and five pure proteins were prepared to give a total of ten samples. Standard curves for the BCA and Bradford assays were generated through serial dilution of 2 mg/mL bovine serum albumin (BSA) standard. The standard curve for the Pierce Dilution-Free Rapid Gold BCA Assay was generated using Pierce Dilution-Free BSA Protein Standards (included with the kit) packaged in a multichannel pipette-friendly tube strip. Four of the ten samples were expected to have a starting concentration of >2 mg/mL, which necessitated a sample dilution step for the BCA and Bradford assays, whereas samples were not required to be diluted for the Dilution-Free Rapid Gold BCA Assay. Samples were then mixed with working reagent from each assay and incubated according to the manufacturer’s instructions.
Advantages of BCA assays
BCA protein quantificationOne of the major advantages of the BCA assay is that it produces a linear response curve. This response curve allows accurate determination of unknown protein concentrations and provides a higher dynamic range than other standard assays.Figure 4. Pierce Dilution-Free Rapid Gold BCA Protein Assay generates a linear standard curve across a wide dynamic range (0–10 mg/mL). Standard curves were produced for the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay (Bio-Rad) with purified BSA in 0.9% saline (0–10 mg/mL). Both assays were conducted using the manufacturer’s protocols in a microplate format. Absorbance readings were taken using the Thermo Scientific Varioskan LUX Multimode Microplate Reader.
BCA assay accuracy
Another major advantage of BCA protein assays is the accuracy as shown through low protein-to-protein variation. Proteins are diverse in their composition and structure, and with some assays, the proteins’ differences in amino acid sequence, isoelectric point (pI), secondary structure, and side chains or prosthetic groups result in variation in the colorimetric response. Since BCA chemistries develop a color response in proportion to the number of peptide bonds present, they are less affected by these differences when compared to dye-binding assays (e.g. Bradford Assays) and therefore exhibit less protein-to-protein variation.Figure 5. Protein quantification results of the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay compared to samples of known concentration. Both assays were conducted in a microplate format, according to the respective manufacturers’ protocols. For the Bradford assay, 5 μL of sample was added to 250 μL of the Bradford working reagent and incubated at room temperature for 5 minutes. For the Dilution-Free Rapid Gold BCA Protein Assay, 10 μL of sample was added to 200 μL of Dilution-Free Rapid Gold BCA working reagent and incubated at room temperature for 5 minutes. Known concentrations of protein samples were based on manufacturers’ indicated concentrations and were confirmed by absorbance at 280 nm.
BCA protein assay protocols
BCA Protein Assay with Dilution-Free BSA Protein StandardsThe Pierce BCA Protein Assay can be performed using two different formats based upon the dynamic range needed to detect the protein concentration of an unknown sample. This BCA assay detects protein concentrations from 20–2,000 μg/mL using a two-component system: Reagent A, a carbonate buffer containing BCA reagent, and Reagent B, a cupric sulfate solution, which are combined to make an apple green–colored working solution that turns purple after 30 minutes at 37°C in the presence of protein. Since the color reaction is not a true endpoint reaction, considerable protocol flexibility is allowed with the Pierce BCA Protein Assay. By increasing the incubation temperature, the sensitivity of the assay can be increased. When using the enhanced tube protocol (i.e., incubating at 60°C for 30 minutes), the working range for the assay shifts to 5–250 μg/mL, facilitating detection of more dilute samples.Figure 6. BCA Protein Assay Kit with Dilution-Free BSA Protein Standards, multichannel pipe compatible protocol.Dilution-Free Rapid Gold BCA Protein Assay Kit protocolThe Dilution-Free Rapid Gold BCA Protein Assay provides the high sensitivity and linearity associated with the BCA assay but performed within a fraction of the time. Simply mix the BCA working solution, add samples and dilution-free standards to your microplate, incubate for 5 minutes at room temperature, and read the absorbance.Figure 7. Dilution-Free Rapid Gold BCA Protein Assay Kit protocol.Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocolA55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays
BCA assays
Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.
BCA assay principles
Chemistry of BCA-based protein assaysThe Pierce BCA Protein Assays combines the well-known reduction of Cu2+ to Cu+ by protein in an alkaline medium (also known as the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+) by bicinchoninic acid (BCA).Figure 1. The first step is the chelation of copper with protein in an alkaline environment to form a blue-colored complex. In this reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate.Single amino acids and dipeptides are unaffected in the biuret reaction, but tripeptides and larger polypeptides or proteins will react to produce the light blue-to-violet complex that absorbs light at 540 nm. One cupric ion forms a colored coordination complex with four to six nearby peptides bonds. The intensity of the color produced is proportional to the number of peptide bonds participating in the reaction.Figure 2. In the second step, BCA reagent, a highly sensitive and selective colorimetric detection reagent, reacts with the cuprous cation (Cu+) that was formed in the first step and produces a purple-color.The BCA-copper complex is water-soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The purple color may be measured at any wavelength between 550 and 570 nm with minimal (less than 10%) loss of signal. The signal induced by the BCA reagent is approximately 100 times more sensitive (lower limit of detection) than the signal using the biuret reagent.Pierce Dilution-Free Rapid Gold BCA protein assay uses the same copper reduction method as traditional BCA assay with a unique copper chelator. In the second step of the color development reaction, the Pierce Dilution-Free Rapid Gold BCA chelator reacts with the reduced (cuprous) cation (Cu+) that was formed in step one to produce an intensely gold-colored reaction product. The copper complex exhibits a strong linear absorbance at 480 nm with increasing protein concentrations.
Dilution-free BCA protein assays
Dilution-free BSA protein standards are available separately or as part of other BCA protein assays. Compared to the Bradford Assay or Pierce BCA Protein assay kit, the Dilution-Free Rapid Gold BCA Protein Assay reduces assay setup by up to 80% by eliminating the need to dilute samples and standards. Additionally, it only requires a 5-minute, room temperature incubation. The dilution-free BSA protein standards are also available in the BCA Protein Assay Kit with Dilution-Free BSA Protein Standards.Figure 3. The Pierce Dilution-Free Rapid Gold BCA Assay reduces setup time by up to 80% compared to other protein assays. The assays were conducted following the manufacturer’s protocols in a microplate format. Five cell lysates and five pure proteins were prepared to give a total of ten samples. Standard curves for the BCA and Bradford assays were generated through serial dilution of 2 mg/mL bovine serum albumin (BSA) standard. The standard curve for the Pierce Dilution-Free Rapid Gold BCA Assay was generated using Pierce Dilution-Free BSA Protein Standards (included with the kit) packaged in a multichannel pipette-friendly tube strip. Four of the ten samples were expected to have a starting concentration of >2 mg/mL, which necessitated a sample dilution step for the BCA and Bradford assays, whereas samples were not required to be diluted for the Dilution-Free Rapid Gold BCA Assay. Samples were then mixed with working reagent from each assay and incubated according to the manufacturer’s instructions.
Advantages of BCA assays
BCA protein quantificationOne of the major advantages of the BCA assay is that it produces a linear response curve. This response curve allows accurate determination of unknown protein concentrations and provides a higher dynamic range than other standard assays.Figure 4. Pierce Dilution-Free Rapid Gold BCA Protein Assay generates a linear standard curve across a wide dynamic range (0–10 mg/mL). Standard curves were produced for the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay (Bio-Rad) with purified BSA in 0.9% saline (0–10 mg/mL). Both assays were conducted using the manufacturer’s protocols in a microplate format. Absorbance readings were taken using the Thermo Scientific Varioskan LUX Multimode Microplate Reader.
BCA assay accuracy
Another major advantage of BCA protein assays is the accuracy as shown through low protein-to-protein variation. Proteins are diverse in their composition and structure, and with some assays, the proteins’ differences in amino acid sequence, isoelectric point (pI), secondary structure, and side chains or prosthetic groups result in variation in the colorimetric response. Since BCA chemistries develop a color response in proportion to the number of peptide bonds present, they are less affected by these differences when compared to dye-binding assays (e.g. Bradford Assays) and therefore exhibit less protein-to-protein variation.Figure 5. Protein quantification results of the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay compared to samples of known concentration. Both assays were conducted in a microplate format, according to the respective manufacturers’ protocols. For the Bradford assay, 5 μL of sample was added to 250 μL of the Bradford working reagent and incubated at room temperature for 5 minutes. For the Dilution-Free Rapid Gold BCA Protein Assay, 10 μL of sample was added to 200 μL of Dilution-Free Rapid Gold BCA working reagent and incubated at room temperature for 5 minutes. Known concentrations of protein samples were based on manufacturers’ indicated concentrations and were confirmed by absorbance at 280 nm.
BCA protein assay protocols
BCA Protein Assay with Dilution-Free BSA Protein StandardsThe Pierce BCA Protein Assay can be performed using two different formats based upon the dynamic range needed to detect the protein concentration of an unknown sample. This BCA assay detects protein concentrations from 20–2,000 μg/mL using a two-component system: Reagent A, a carbonate buffer containing BCA reagent, and Reagent B, a cupric sulfate solution, which are combined to make an apple green–colored working solution that turns purple after 30 minutes at 37°C in the presence of protein. Since the color reaction is not a true endpoint reaction, considerable protocol flexibility is allowed with the Pierce BCA Protein Assay. By increasing the incubation temperature, the sensitivity of the assay can be increased. When using the enhanced tube protocol (i.e., incubating at 60°C for 30 minutes), the working range for the assay shifts to 5–250 μg/mL, facilitating detection of more dilute samples.Figure 6. BCA Protein Assay Kit with Dilution-Free BSA Protein Standards, multichannel pipe compatible protocol.Dilution-Free Rapid Gold BCA Protein Assay Kit protocolThe Dilution-Free Rapid Gold BCA Protein Assay provides the high sensitivity and linearity associated with the BCA assay but performed within a fraction of the time. Simply mix the BCA working solution, add samples and dilution-free standards to your microplate, incubate for 5 minutes at room temperature, and read the absorbance.Figure 7. Dilution-Free Rapid Gold BCA Protein Assay Kit protocol.
Lowry assays
Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocol
Ordering
A55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213
Documents
Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays
Resources
Pierce Protein methods – an encyclopedia of articles about protein analysisOverview of Protein AssaysChemistry of Protein AssaysProtein Assay Data AnalysisProtein assay technical guide – tools and reagents for improved quantitation of total or specific proteins.Protein assay compatibility table – summarizes compatible substances for several popular protein assays.Protein Analysis Learning Center – resources for different protein analysis techniquesProtein Biology Application Notes – journal-style articles based on research applications and proof-of-concept experimentsLiberate yourself with Pierce Dilution-Free protein assaysFor Research Use Only. Not for use in diagnostic procedures.
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BCA 测蛋白浓度的原理 - 知乎
BCA 测蛋白浓度的原理 - 知乎切换模式写文章登录/注册BCA 测蛋白浓度的原理Iris一个普通人,在学习如何给小朋友讲好故事BCA 全称是Bicinchoninic Acid Assay, 也叫Smith Assay,因为这个方法是Paul K. Smith 发明的……这个方法通过展示不同浓度样品的颜色变化来判断蛋白的浓度。图片源自网络BCA分析主要依靠两个反应。首先,蛋白质中的肽键可将硫酸铜中的Cu2+还原成Cu +(反应依赖于温度),其中减少的Cu 2+的量与溶液中存在的蛋白质的量成比例。接下来,每个Cu +离子都与两个分子的bicinchoninic acid螯合物形成紫色复合物,可强烈吸收562 nm波长的光。图片源自网络半胱氨酸/胱氨酸,酪氨酸和色氨酸侧链的存在会影响蛋白质样品中的二辛可宁酸Cu +复合物。在较高的温度(37至60°C)下,肽键有助于反应复合物的形成。建议在更高的温度下孵育BCA分析,以增加分析灵敏度,同时最大程度地减少由不相等的氨基酸组成引起的差异。[3] 溶液中存在的蛋白质量可以通过测量吸收光谱并与已知浓度的蛋白质溶液进行定量。参考资料:Wikipedia Smith, P.K.; et al. (1985). "Measurement of protein using bicinchoninic acid". Anal. Biochem. 150 (1): 76–85. doi:10.1016/0003-2697(85)90442-7. PMID 3843705.^ Olsen BJ, Markwell J (2007). "Assays for the Determination of Protein Concentration" (PDF). Current Protocols in Protein Science: 14–17.发布于 2021-02-09 17:24生物实验赞同 529 条评论分享喜欢收藏申请
如何使用BCA进行蛋白浓度测定 - 知乎
如何使用BCA进行蛋白浓度测定 - 知乎切换模式写文章登录/注册如何使用BCA进行蛋白浓度测定爱分享的Leo博士中山大学 医学博士实验原理BCA法基于双缩脲原理,碱性条件下蛋白质将Cu2+还原成Cu+,BCA鳌合Cu+作为显色剂,产生蓝紫色并在562nm有吸收峰,单价Cu+与蛋白质呈剂量相关性。可以根据待测蛋白在562nm处的吸光度计算待测蛋白浓度。1. 蛋白标准品的准备 a. 取0.8ml蛋白标准配制液加入到一管蛋白标准(20mg BSA)中,充分溶解后配制成25mg/ml的蛋白标准溶液。配制后可立即 使用,也可以-20ºC长期保存。 b. 取适量25mg/ml蛋白标准,稀释至终浓度为0.5mg/ml。例如取20µl 25mg/ml蛋白标准,加入980µl稀释液即可配制成 0.5mg/ml蛋白标准。蛋白样品在什么溶液中,标准品也宜用什么溶液稀释。但是为了简便起见,也可以用0.9% NaCl或PBS 稀释标准品。稀释后的0.5mg/ml蛋白标准可以-20ºC长期保存。 2. BCA工作液配制 根据样品数量,按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液,充分混匀。例如5ml BCA试剂A加100µl BCA试剂B,混匀,配制成5.1ml BCA工作液。BCA工作液室温24小时内稳定。 3. 蛋白浓度测定 a. 将标准品按0、1、2、4、8、12、16、20µl加到96孔板的标准品孔中,加标准品稀释液补足到20µl,相当于标准品浓度分 别为0、0.025、0.05、0.1、0.2、0.3、0.4、0.5mg/ml。b. 加适当体积样品到96孔板的样品孔中。如果样品不足20µl,需加标准品稀释液补足到20µl。请注意记录样品体积。 c. 各孔加入200µl BCA工作液,37ºC放置20-30分钟。 注: 也可以室温放置2小时,或60ºC放置30分钟。BCA法测定蛋白浓度时,颜色会随着时间的延长不断加深。并且显色反 应会因温度升高而加快。如果浓度较低,适合在较高温度孵育,或适当延长孵育时间。 d. 用酶标仪测定A562,或540-595nm之间的其他波长的吸光度。 e. 根据标准曲线和使用的样品体积计算出样品的蛋白浓度。是否每次测定时都需要做标准曲线? 建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深,并且显色反应的速度和温度有关,所 以除非精确控制显色反应的时间和温度,否则如需精确测定宜每次都做标准曲线。SCI方法写作实验太常规了,通常都是一笔带过的。发布于 2021-12-28 15:32生物化学分子生物学化学赞同 12115 条评论分享喜欢收藏申请
常见的三种蛋白定量法,你用的哪一种? - 知乎
常见的三种蛋白定量法,你用的哪一种? - 知乎首发于生物医学实验切换模式写文章登录/注册常见的三种蛋白定量法,你用的哪一种?卓知生物真实、稳定、service+1、BCA法原理:BCA (Bicinchoninic acid,2,2-联喹啉-4,4-二甲酸二钠),与含二价铜离子的硫酸铜组成BCA检测试剂(商业试剂盒中,碱性的BCA混合溶液与硫酸铜溶液分别包装,标记为A液和B液,二者在实验前比例混合,溶液呈绿色),在碱性条件下,二价铜离子可被蛋白质还原成一价铜离子,一价铜离子能够与BCA相互作用,两分子BCA鳌合一个铜离子,形成稳定的紫色复合物,在562nm处显示强吸光性。在一定浓度范围内,复合物的光密度与蛋白质含量呈线性关系,通过酶标仪或者分光光度计以标准品蛋白做标准曲线,随后检测靶标蛋白562nm波长处的吸光值,即可换算出靶标蛋白浓度。特点:BCA法作为已知最灵敏的检测方法之一,灵敏度高,普通BCA试剂盒检测范围为20-2000μg/ml,增强型BCA试剂盒最低检测浓度可到0.5μg/ml,检测范围广且线性稳定;同时该方法操作较为便捷,正常情况下可在45分钟内完成测定;不过由于反应中涉及“氧化”和“螯合”两个过程,BCA法检测结果会受到还原剂(如DTT,巯基乙醇等)、金属离子螯合剂(如EDTA等)干扰,不易受表面活性剂(Triton X-100、SDS等)影响。02Bradford法原理:Bradford法也称作考马斯亮蓝法(Bradford为发明人),考马斯亮蓝G250(Coomassie brilliant blue G250),是一种甲基取代的三苯基甲烷,每分子包含两个SO3-H基团,呈酸性,该磺酸基团能够通过范德华力与蛋白质的碱性基团结合形成稳定的染料-蛋白复合物,在595nm波长处有最大吸收峰,游离考马斯亮蓝G250溶液呈现棕红色,与蛋白反应之后变成蓝色;并且在一定浓度范围内,复合物的光密度与蛋白质含量呈线性关系。通过酶标仪或者分光光度计以标准品蛋白做标准曲线,随后检测靶标蛋白595nm波长处的吸光值,即可换算出靶标蛋白浓度。特点:Bradford法作为另一种最灵敏的检测方法,其灵敏度同样可以达到微克级别;并且仅需一种反应试剂即可完成检测,操作十分便捷;同时考马斯亮蓝染料与蛋白样本结合所需时间极短,2分钟即可形成稳定复合物,完成一次检测耗时仅需几分钟。但是,由于蛋白-染料稳定复合物之间是分子间作用力,故Bradford法会受到表面活性剂(Triton X-100、SDS等)干扰,除此之外,不同靶标蛋白中碱性氨基酸(范德华力作用)以及芳香族氨基酸(疏水作用)含量不一,对考马斯亮蓝的结合能力差异较大;而且随着蛋白浓度增加,线性关系会出现偏差。因此Bradford法与BCA法一样,也是一种不完美的检测手段。[延伸]:检测蛋白浓度的考马斯亮蓝和染色PAGE胶的考马斯亮蓝不是同一种物质,前者采用考马斯亮蓝G250,后者采用考马斯亮蓝R250,G250和R250分子基本骨架一样,但是G250多了两个甲基,与蛋白反应迅速,染胶慢且脱色困难,故用于蛋白定量;R250与蛋白反应较缓慢,染胶较快且易于洗脱,故用于PAGE胶染色。03UV法(NanoDrop)原理:UV法即紫外分光光度法,蛋白质分子中的芳香族氨基酸,包括色氨酸、赖氨酸、苯丙氨酸,含有可以吸收紫外光的共轭双键,最大吸收峰在280nm波长处,且在此波长内吸收峰的光密度值与其浓度成线性关系。通过分光光度计检测靶标蛋白280nm波长,即可根据Beer-Lambert定律(A=E*C*l;A代表吸光度,E代表消光系数,C代表蛋白质浓度,l代表光径长度,其中消光系数可以根据蛋白质序列估测)换算出靶标蛋白的浓度。特点:相较于上述两种检测手段,UV法一个最大的优势就是不用额外添加检测试剂,因此待测样本是可以回收利用的,不影响活性;这也使得UV法具有无与伦比的便捷性和高效性,通过Nanodrop等仪器,我们甚至可以在几秒内直接读出一个蛋白样本的浓度;UV法检测的灵敏度同样可以达到微克级别。UV法优势明显,缺点也极为突出。由于不同蛋白有不同的酪氨酸和色氨酸含量,对紫外光的吸收能力不同,故要准确测量,必须要有待测蛋白质或其它蛋白的纯品作标准品参考;其次,很多化合物在280nm处有吸光值,对实验结果造成干扰,其中核酸影响尤为严重,核酸最大吸收峰在260nm处,故溶液中可能存在核酸时,必须同时测定OD260和OD280,然后根据两种波长的吸收度的比值,通过经验公式校正,以消除核酸的影响 。发布于 2021-07-21 14:58生物化学分子间作用力生物医学赞同 253 条评论分享喜欢收藏申请转载文章被以下专栏收录生物医学实验细胞干货、蛋白干货、检测干货、病理干
BCA蛋白浓度测定试剂盒(P0012)
BCA蛋白浓度测定试剂盒(P0012)
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试剂>
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P0011
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BCA蛋白浓度测定试剂盒
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产品编号:
P0012
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产品简介
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P0012S
BCA蛋白浓度测定试剂盒
200次
172.00元
P0012
BCA蛋白浓度测定试剂盒
500次
329.00元
P0011
BCA蛋白浓度测定试剂盒
5000次
1592.00元
BCA蛋白浓度测定试剂盒(BCA Protein Assay Kit)是根据目前世界上最常用的两种蛋白浓度检测方法之一BCA法研制而成,实现了蛋白浓度测定的简单、高稳定性、高灵敏度和高兼容性。
灵敏度高,检测浓度下限达到25μg/ml,最小检测蛋白量达到0.5μg,待测样品体积为1-20μl。
在50-2000μg/ml浓度范围内有较好的线性关系。
BCA法测定蛋白浓度不受绝大部分样品中的化学物质的影响,可以兼容样品中高达5%的SDS,5%的Triton X-100,5%
的Tween 20、60、80。但本试剂盒受螯合剂和略高浓度的还原剂的影响,需确保EDTA低于10mM,无EGTA,二硫苏糖醇
(DTT)低于1mM,β-巯基乙醇(β-Mercaptoethanol)低于0.01%。不适用BCA法时建议试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。
BCA蛋白浓度测定试剂盒对样品中各种物质的详细的兼容性,请参见碧云天如下网页:
http://www.beyotime.com/Compatibility Chart For BCA Kit.pdf
每个试剂盒可以检测5000个样品。
包装清单:
产品编号
产品名称
包装
P0012-1
BCA试剂 A
100ml
P0012-2
BCA试剂 B
3ml
P0012-3
蛋白标准(BSA)
30mg
P0012-4
蛋白标准配制液
1.5ml
―
说明书
1份
保存条件:
室温保存。蛋白标准配制成溶液后-20℃冻存。
注意事项:
需酶标仪一台,测定波长为540-595nm之间,562nm最佳。需96孔板。如果没有酶标仪,也可以使用普通的分光光度计测定,但测定时,需根据比色皿的最小检测体积,适当加大BCA工作液的用量使不小于最小检测体积,样品和标准品的用量可相应按比例放大也可不变。使用分光光度计测定蛋白浓度时,每个试剂盒可以测定的样品数量可能会显著减少。
如发现样品稀释液或裂解液本身就有较高背景,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。
为了加快BCA法测定蛋白浓度的速度可以适当用微波炉加热,但是切勿过热。
EDTA浓度必须小于10mM,不兼容EGTA。不适用BCA法时,请试用碧云天生产的Bradford蛋白浓度测定试剂盒(P0006)。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。
使用说明:
1.蛋白标准品的准备
a.取1.2ml蛋白标准配制液加入到一管蛋白标准(30mg BSA)中,充分溶解后配制成25mg/ml的蛋白标准溶液。配制后可立即使用,也可以-20℃长期保存。
b.取适量25mg/ml蛋白标准,稀释至终浓度为0.5mg/ml。例如取20µl 25mg/ml蛋白标准,加入980µl稀释液即可配制成0.5mg/ml蛋白标准。蛋白样品在什么溶液中,标准品也宜用什么溶液稀释。但是为了简便起见,也可以用0.9% NaCl或PBS稀释标准品。稀释后的0.5mg/ml蛋白标准可以-20℃长期保存。
2.BCA工作液配制
根据样品数量,按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液,充分混匀。例如5mlBCA试剂A加100μl BCA试剂B,混匀,配制成5.1ml BCA工作液。BCA工作液室温24小时内稳定。
3.蛋白浓度测定
a.将标准品按0、1、2、4、8、12、16、20μl加到96孔板的标准品孔中,加标准品稀释液补足到20μl,相当于标准品浓度分别为0、0.025、0.05、0.1、0.2、0.3、0.4、0.5mg/ml。
b.加适当体积样品到96孔板的样品孔中。如果样品不足20μl,需加标准品稀释液补足到20μl。请注意记录样品体积。
c.各孔加入200μl BCA工作液,37℃放置20-30分钟。
注: 也可以室温放置2小时,或60℃放置30分钟。BCA法测定蛋白浓度时,颜色会随着时间的延长不断加深。并且显色反应会因温度升高而加快。如果浓度较低,适合在较高温度孵育,或适当延长孵育时间。
d.用酶标仪测定A562,或540-595nm之间的其他波长的吸光度。
e.根据标准曲线和使用的样品体积计算出样品的蛋白浓度。
常见问题:
1. 测定标准曲线时发现随着标准品浓度的增加吸光度或颜色没有明显变化。
可能的原因是样品中含有严重干扰BCA法测定蛋白浓度的物质,详细的BCA法的兼容性列表请参考碧云天如下网页:http://www.beyotime.com/Compatibility Chart For BCA Kit.pdf
2.是否每次测定时都需要做标准曲线?
建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深,并且显色反应的速度和温度有关,所以除非精确控制显色反应的时间和温度,否则如需精确测定宜每次都做标准曲线。
相关产品:
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P0006
Bradford蛋白浓度测定试剂盒
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P0007
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BCA蛋白浓度测定试剂盒
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High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
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2009 Jun;25(3):131-7.
(IF 4.326)
104. Wang XD, Meng MX, Gao LB, Liu T, Xu Q, Zeng S.
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Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp.
INT J PHARMACOL.
2009 Aug 13;378(1-2):1-8.
(IF 0.692)
105. Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL.
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Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats.
Brain Res.
2009 Aug 11;1284:1-11.
(IF 2.733)
106. Ding D, Huang P, Sun H, Xue Q, Pan Y, Chen S.
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Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection.
J PHARMACEUT BIOMED.
2009 Aug 15;50(1):79-85.
(IF 3.209)
107. Liu X, Shi S, Ye J, Liu L, Sun M, Wang C.
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Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-kappaB/COX-2 activation and apoptosis in HaCaT cells.
J PHOTOCH PHOTOBIO B.
2009 Aug 3;96(2):109-16.
(IF 4.383)
108. Zhang Z, Wang Q, Li P, Zhou Y, Li S, Yi W, Chen A, Kong P, Hu C.
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Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance.
Cancer Epidemiol.
2009 Aug;33(2):130-6.
(IF 2.179)
109. Ma K, Hu M, Qi Y, Qiu L, Jin Y, Yu J, Li B.
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Structure-transfection activity relationships with glucocorticoid-polyethyl-enimine conjugate nuclear gene delivery systems.
Biomaterials.
2009 Aug;30(22):3780-9.
(IF 10.317)
110. Liao Z, Huang C, Zhou F, Xiong J, Bao J, Zhang H, Sun W, Xie C, Zhou Y.
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Radiation enhances suicide gene therapy in radioresistant laryngeal squamous cell carcinoma via activation of a tumor-specific promoter.
Cancer Lett.
2009 Sep 28;283(1):20-8.
(IF 7.36)
111. Feng B, Huang CG, Chen RH, Guo YW, Jiao BH.
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2'-Epi-2'-O-acetylthevetin B induces apoptosis partly via Ca(2+)-mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells.
Cell Biol Int.
2009 Sep;33(9):918-25.
(IF 2.571)
112. Ye Y, Hu SJ, Li L.
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Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
FEBS Lett.
2009 Sep 17;583(18):2997-3003.
(IF 3.057)
113. Shi GS, Ren LF, Wang LZ, Lin HS, Wang SB, Tong YQ.
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H2O2/HCl and heat-treated Ti-6Al-4V stimulates pre-osteoblast proliferation and differentiation.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2009 Sep;108(3):368-75.
(IF 0.27)
114. Chen Y, Wang J, Yao Y, Yuan W, Kong M, Lin Y, Geng D, Nie R.
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CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway.
FEBS Lett.
2009 Sep 3;583(17):2811-8.
(IF 3.057)
115. Chen WL, Qian Y, Meng WF, Pang JY, Lin YC, Guan YY, Chen SP, Liu J, Pei Z, Wang GL.
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A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.
Biochem Pharmacol.
2009 Oct 15;78(8):941-50.
(IF 4.96)
116. Ma K, Hu MX, Qi Y, Zou JH, Qiu LY, Jin Y, Ying XY, Sun HY.
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PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.
Biomaterials.
2009 Oct;30(30):6109-18.
(IF 10.317)
117. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, Chen Q.
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The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice.
BIOCHEM BIOPH RES CO.
2009 Oct 23;388(3):595-600.
(IF 2.985)
118. Lin Y, Chen Y, Yang X, Xu D, Liang S.
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Proteome analysis of a single zebrafish embryo using three different digestion strategies coupled with liquid chromatography-tandem mass spectrometry.
Anal Biochem.
2009 Nov 15;394(2):177-85.
(IF 2.877)
119. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C.
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Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells.
Cancer Lett.
2009 Nov 1;284(2):229-37.
(IF 7.36)
120. Li H, Zhang L, Huang Q.
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Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.
Behav Brain Res.
2009 Dec 14;205(1):32-7.
(IF 2.977)
121. Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J.
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Nuclear proteome analysis of cisplatin-treated HeLa cells.
MUTAT RES-REV MUTAT.
2010;691(1-2):1-8.
(IF 5.803)
122. Gong HS, Meng XC, Wang H.
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Plantaricin MG active against Gram-negative bacteria produced by Lactobacillus plantarum KLDS1.0391 isolated from"Jiaoke", a traditional fermented cream from China.
Food Control.
21 (2010) 89–96.
(IF 4.258)
123. Li F, Gong QH, Wu Q, Lu YF, Shi JS.
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Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.
PHARMACOL BIOCHEM BE.
2010;96(3):301-5.
(IF 2.519)
124. Li H, Fong C, Chen Y, Cai G, Yang M.
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beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling.
Arch Biochem Biophys.
2010 15;496(2):77-83.
(IF 3.391)
125. Han J, Zhou YP, Jiang YZ, He YT, Mei F.
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Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec).
Acta Histochem.
2010;112(3):215-21.
(IF 2.107)
126. Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH.
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2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
CHEM-BIOL INTERACT.
2010;183(1):142-53.
(IF 3.723)
127. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M.
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Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).
INT J PHARMACOL.
2010;389(1-2):114-21.
(IF 0.692)
128. Lin Y, Xu J, Cao L, Han Y, Gao J, Xie N, Zhao X, Jiang H, Chi Z.
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Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine.
Neurosci Lett.
2010;474(1):22-5.
(IF 2.274)
129. Li Q, Wu D, Zhang L, Zhang Y.
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Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells.
Exp Gerontol.
2010;45(11):842-7.
(IF 3.376)
130. Li GG, Liang XF, Xie Q, Li G, Yu Y, Lai K.
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Gene structure, recombinant expression and functional characterization of grass carp leptin.
GEN COMP ENDOCR.
2010;166(1):117-27.
(IF 2.426)
131. Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X, Wang J.
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Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis.
Eur J Pharmacol.
2010;627(1-3):304-12.
(IF 3.263)
132. He F, Zhang F, Yang G, Wang X, Zhao S.
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Enhanced initial proliferation and differentiation of MC3T3-E1 cells on HF/HNO3 solution treated nanostructural titanium surface.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2010;110(4):e13-22.
(IF 0.27)
133. Yan J, Sun XB, Wang HQ, Zhao H, Zhao XY, Xu YX, Guo JC, Zhu CQ.
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Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain.
Brain Res.
2010;1347:132-41.
(IF 2.733)
134. Song XZ, Xu JQ, Wang T, Liu FH.
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Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA.
Livestock Science.
2010;128:75–81.
(IF 1.376)
135. Yuan H, Zhang W, Du YZ, Hu FQ.
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Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery.
INT J PHARMACOL.
2010;392(1-2):224-31.
(IF 0.692)
136. Yu Q, Zhao Z, Sun J, Guo W, Fu J, Burnstock G, He C, Xiang Z.
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Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
Histochem Cell Biol.
2010;133(2):177-88.
(IF 3.418)
137. Hu H, Zhang Y, Zou M, Yang S, Liang XQ.
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Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.
J CANCER RES CLIN.
2010;136(9):1407-14.
(IF 3.656)
138. Ding XL, Wang YH, Ning LP, Zhang Y, Ge HY, Jiang H, Wang R, Yue SW.
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Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
Behav Brain Res.
2010;208(1):194-201.
(IF 2.977)
139. Huang LH, Hu JQ, Tao WQ, Li YH, Li GM, Xie PY, Liu XS, Jiang J.
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Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.
Eur J Pharmacol.
2010;645(1-3):9-13.
(IF 3.263)
140. Sun J, Liu X, Li Q.
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Molecular cloning, expression and antioxidant activity of a peroxiredoxin 2 homologue from Lampetra japonica.
FISH SHELLFISH IMMUN.
2010;28(5-6):795-801.
(IF 3.298)
141. Wang S, Liu S, Liu H, Wang J, Zhou S, Jiang RJ, Bendena WG, Li S.
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20-hydroxyecdysone reduces insect food consumption resulting in fat body lipolysis during molting and pupation.
J Mol Cell Biol.
2010;2(3):128-38.
(IF 4.0)
142. Cao BY, Yang YP, Luo WF, Mao CJ, Han R, Sun X, Cheng J, Liu CF.
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Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway.
J Ethnopharmacol.
2010;131(1):122-9.
(IF 3.69)
143. Liu J, Wang A, Li L, Huang Y, Xue P, Hao A.
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Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine- induced status epilepticus.
SEIZURE-EUR J EPILEP.
2010;19(3):165-72.
(IF 2.522)
144. Li C, Xing G, Dong M, Zhou L, Li J, Wang G, Zou D, Wang R, Liu J, Niu Y.
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Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins.
Eur J Pharmacol.
2010;635(1-3):96-102.
(IF 3.263)
145. Zhou CL, Yu XJ, Chen LM, Jiang H, Li CY.
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Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.
REGUL PEPTIDES.
2010 Feb 25;160(1-3):115-20.
(IF 1.813)
146. Chen S, Chen Y, Hu C, Jing H, Cao Y, Liu X.
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Association of clinicopathological features with UbcH10 expression in colorectal cancer.
J CANCER RES CLIN.
2010 Mar;136(3):419-26.
(IF 3.656)
147. Wu GJ, Zhou LZ, Wang KW, Chen F, Sun Y, Duan YR, Zhu YJ, Gu HC.
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Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection.
J COLLOID INTERF SCI.
2010 May 15;345(2):427-32.
(IF 7.489)
148. Wang YX, Xu XY, Su WL, Wang Q, Zhu WX, Chen F, Jin G, Liu YJ, Li YD, Sun YP, Gao WC, Ruan CP.
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Activation and Clinical Significance of p38 MAPK Signaling Pathway in Patients With Severe Trauma.
J Surg Res.
2010 Jun 1;161(1):119-25.
(IF 1.841)
149. Yuan D, Pan Y, Zhang J, Shao C.
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Role of nuclear factor-kappaB and P53 in radioadaptive response in Chang live cells.
MUTAT RES-REV MUTAT.
2010 Jun 1;688(1-2):66-71.
(IF 5.803)
150. Zhang JC, Liu CL, Li YP, Sun J, Wang P, Di KQ, Chen H, Zhao YY .
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Effect of yttrium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro.
Journal Of Rare Earths.
2010 Jun;28(3):466-470.
(IF 2.846)
151. Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q.
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MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation.
Mol Biol Rep.
2010 Jul;37(6):2951-6.
(IF 1.402)
152. Zhu J, Zhang L, Jin X, Han X, Sun C, Yan J.
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beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway.
Mol Biol Rep.
2010 Jul;37(6):2653-63.
(IF 1.402)
153. Wang S, Lv X, Zhang K, Lin T, Liu X, Yuan J, Dai Y, Li N.
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Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells.
Mol Biol Rep.
2010 Oct;37(3):3193-8.
(IF 1.402)
154. Deng X, Cheng J, Zhang Y, Li N, Chen L.
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Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.
Acta Diabetol.
2010 Dec;47(1):177-85.
(IF 3.418)
155. Zhao L, Yang R, Cheng L, Wang M, Jiang Y, Wang S.
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LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells.
J Surg Res.
2010 Dec;171(2):819-25.
(IF 1.841)
156. Chen Z, Liu S, Sumida T, Sun S, Wei Y, Liu M, Dong Z, Zhang F, Hamakawa H, Wei F.
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Silencing Id-1 with RNA Interference Inhibits Adenoid Cystic Carcinoma in Mice.
J Surg Res.
2011 Jul;169(1):57-66.
(IF 1.841)
157. Zhang L, Jiang G, Yao F, He Y, Liang G, Zhang Y, Hu B, Wu Y, Li Y, Liu H.
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Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellularcarcinoma.
PLoS One.
2012;7(5):e37865.
(IF 2.74)
158. Xiao O, Xie ZL, Lin BW, Yin XF, Pi RB, Zhou SY.
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Minocycline inhibits alkali burn-induced corneal neovascularization in mice.
PLoS One.
2012;7(7):e41858.
(IF 2.74)
159. Jiang L, Lin J, Han H, Dong H, Zhao Q, Zhu S, Huang B.
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Identification and Characterization of Eimeria tenella Apical Membrane Antigen-1 (AMA1).
PLoS One.
2012;7(7):e41115.
(IF 2.74)
160. Zhang YS, He L, Liu B, Li NS, Luo XJ, Hu CP, Ma QL, Zhang GG, Li YJ, Peng J.
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A novel pathway of NADPH oxidase/vascular peroxidase 1 in mediating oxidative injury followingischemia-reperfusion.
Basic Res Cardiol.
2012;107(3):266.
(IF 11.981)
161. Wu J, Lai G, Wan F, Xiao Z, Zeng L, Wang X, Ye F, Lei T.
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Knockdown of checkpoint kinase 1 is associated with the increased radiosensitivity ofglioblastoma stem-like cells.
Tohoku J Exp Med.
2012;226(4):267-74.
(IF 1.441)
162. Liu P, Shi Y, Yang Y, Cao Y, Shi Y, Li H, Liu J, Lin J, Jin Y.
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Schistosoma Japonicum UDP-Glucose 4-Epimerase Protein Is Located on the Tegument andInduces Moderate Protection against Challenge Infection.
PLoS One.
2012;7(7):e42050.
(IF 2.74)
163. Du HM, Zheng XH, Wang LY, Tang W, Liu L, Jing W, Lin YF, Tian WD, Long J.
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The Osteogenic Response of Undifferentiated Human Adipose-Derived Stem Cells underMechanical Stimulation.
Cells Tissues Organs.
2012;196(4):313-24.
(IF 2.064)
164. Wang Y, Xie S, Liu C, Wu Y, Liu Y, Cai Y.
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Inhibitory effect of liquiritigenin on migration via downregulation proMMP-2 and PI3K/Akt signalingpathway in human lung adenocarcinoma A549 cells.
Nutr Cancer.
2012;64(4):627-34.
(IF 2.363)
165. Song Z, Li Y, Liu Y, Xin J, Zou X, Sun W.
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α-Enolase, an Adhesion-Related Factor of Mycoplasma bovis.
PLoS One.
2012;7(6):e38836.
(IF 2.74)
166. Baohua Y, Li L.
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Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts.
Cell Biol Int.
2012 Jan;36(1):105-8.
(IF 2.571)
167. Li Y, Wang J, Grebogi C, Foote M, Liu F.
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A syringe-focused ultrasound device for simultaneous injection of DNA and gene transfer.
J Gene Med.
2012 Jan;14(1):54-61.
(IF 3.258)
168. Zhong Y, Liu T, Guo Z.
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Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κBpathways in rat vascular smooth muscle cells.
Inflamm Res.
2012 Jan;61(1):61-7.
(IF 3.174)
169. Liang G, Chen H, Zhang S, Wu W, Kong J.
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Magnetic nanosensors for highly sensitive and selective detection of bacillus Calmette-Guérin.
Analyst.
2012 Feb 7;137(3):675-9.
(IF 3.978)
170. Li XJ, Liu DP, Chen HL, Pan XH, Kong QY, Pang QF.
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Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice.
Int Immunopharmacol.
2012 Feb;12(2):460-4.
(IF 3.943)
171. Han X, Lu M, Wang S, Lv D, Liu H.
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Targeting IKK/NF-κB pathway reduces infiltration of inflammatory cells and apoptosis after spinalcord injury in rats.
Neurosci Lett.
2012 Mar 5;511(1):28-32.
(IF 2.274)
172. Zhang X, Xu Y, Wang J, Zhou Q, Pu S, Jiang W, Du D.
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The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNFoverexpression and hind paw mechanical allodynia in spinal nerve ligated rats.
J Neural Transm.
2012 Mar;119(3):329-36.
(IF 3.505)
173. Zhao S, Zhao G, Xie H, Huang Y, Hou Y.
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A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumorgrowth.
Braz J Med Biol Res.
2012 Mar;45(3):230-7.
(IF 2.023)
174. Yu SJ, Liu HC, Ling-Ling E, Wang DS, Zhu GX.
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Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats.
EXP BIOL MED.
2012 Apr;237(4):395-406.
(IF 3.139)
175. Wang T, Fu F, Han B, Zhang L, Zhang X.
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Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice byattenuating advanced glycation end product-mediated neuroinflammation.
J Neuroimmunol.
2012 Apr;245(1-2):79-86.
(IF 3.125)
176. Liu M, Zhou G, Song W, Li P, Liu H, Niu X, Fan Y.
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Effect of nano-hydroxyapatite on the axonal guidance growth of rat cortical neurons.
Nanoscale.
2012 May 21;4(10):3201-7.
(IF 6.895)
177. Xu MF, Xiong YY, Liu JK, Qian JJ, Zhu L, Gao J.
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Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitivedeficits in mice and apoptosis in SH-SY5Y cells.
Acta Pharmacol Sin.
2012 May;33(5):578-87.
(IF 5.064)
178. Yu H, Li Q, Zhou X, Kolosov VP, Perelman JM.
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Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+influx in human airway epithelial cells.
J BIOCHEM MOL TOXIC.
2012 May;26(5):179-86.
(IF 3.606)
179. Zuo K, Li D, Pulli B, Yu F, Cai H, Yuan X, Zhang X, Lv Z.
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Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancercell growth in vitro and in vivo.
BIOCHEM BIOPH RES CO.
2012 May 4;421(2):396-402.
(IF 2.985)
180. Chen M, Hu M, Wang D, Wang G, Zhu X, Yan D, Sun J.
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Multifunctional Hyperbranched Glycoconjugated Polymers Based on Natural Aminoglycosides.
BIOCONJUGATE CHEM.
2012 Jun 20;23(6):1189-99.
(IF 4.031)
181. Sun D, Wang Y, Liu C, Zhou X, Li X, Xiao A.
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Effects of nitric oxide on renal interstitial fibrosis in rats with unilateral ureteral obstruction.
Life Sci.
2012 Jun 14;90(23-24):900-9.
(IF 3.647)
182. Zhao XY, Zhu YJ, Chen F, Wu J.
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Calcium phosphate nanocarriers dual-loaded with bovine serum albumin and Ibuprofen: facilesynthesis, sequential drug loading and sustained drug release.
CHEM-ASIAN J.
2012 Jun;7(7):1610-5.
(IF 4.056)
183. Yang L, Cheng F, Liu T, Lu JR, Song K, Jiang L, Wu S, Guo W.
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Comparison of mesenchymal stem cells released from poly(N-isopropylacrylamide) copolymerfilm and by trypsinization.
Biomed Mater.
2012 Jun;7(3):035003.
(IF 3.174)
184. Sun X, Cheng F, Meng B, Yang B, Song W, Yuan H.
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Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptorin a model of chronic ocular hypertension.
Mol Biol Rep.
2012 Jun;39(6):6607-14.
(IF 1.402)
185. Ren M, Qin D, Li K, Qu J, Wang L, Wang Z, Huang A, Tang H.
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Correlation between hepatitis B virus protein and microRNA processor Drosha in cells expressingHBV.
ANTIVIR RES.
2012 Jun;94(3):225-31.
(IF 4.101)
186. Yang XH, Wang YH, Wang JJ, Liu YC, Deng W, Qin C, Gao JL, Zhang LY.
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Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remotekidney injury in a mouse hindlimb ischemia-reperfusion model.
Peptides.
2012 Jul;36(1):60-70.
(IF 2.843)
187. Li TT, Zhang YS, He L, Liu B, Shi RZ, Zhang GG, Peng J.
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Inhibition of vascular peroxidase alleviates cardiac dysfunction and apoptosis induced by ischemia-reperfusion.
CAN J PHYSIOL PHARM.
2012 Jul;90(7):851-62.
(IF 1.946)
188. Zhang Y, Xu Y, Zhu Q, Zhao F, Luo J, Zhang X, Wang X.
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Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.
Synapse.
2012 Jul;66(7):622-9.
(IF 2.318)
189. Huang Q, Deng J, Xie Z, Wang F, Chen S, Lei B, Liao P, Huang N, Wang Z, Wang Z, Cheng Y.
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Effective gene transfer into central nervous system following ultrasound-microbubbles-inducedopening of the blood-brain barrier.
Ultrasound Med Biol.
2012 Jul;38(7):1234-43.
(IF 2.514)
190. Zhong X, Li W, Huang X, Zhang L, Yimamu M, Raiput N, Zhou Y, Wang T.
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Impairment of cellular immunity is associated with overexpression of heat shock protein 70 inneonatal pigs with intrauterine growth retardation.
CELL STRESS CHAPERON.
2012 Jul;17(4):495-505.
(IF 2.892)
191. Sang H, Zhang L, Li J.
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Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in humanbronchiolar epithelium cells independent of the mitochondria permeability transition pore.
Food Chem Toxicol.
2012 Jul;50(7):2417-23.
(IF 4.679)
192. Hao M, Kuang HY, Fu Z, Gao XY, Liu Y, Deng W.
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Exenatide prevents high-glucose-induced damage of retinal ganglion cells through a mitochondrialmechanism.
Neurochem Int.
2012 Jul;61(1):1-6.
(IF 3.881)
193. Jiang H, Yuan H, Liang Y, Xia S, Zhao Q, Wu Q, Zhang L, Liang Z, Zhang Y.
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A hydrophilic immobilized trypsin reactor with N-vinyl-2-pyrrolidinone modified polymermicroparticles as matrix for highly efficient protein digestion with low peptide residue.
J Chromatogr A.
2012 Jul 13;1246:111-6.
(IF 4.049)
194. Xiong W, Luo Y, Zhang C, Tan D, Zuo S.
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Expression, Purification of Recombinant Human Mitochondrial Transcription TerminationFactor 3(hMTERF3) and Preparation of Polyclonal Antibody Against hMTERF3.
APPL BIOCHEM BIOTECH.
2012 Aug;167(8):2318-29.
(IF 2.277)
195. Zhang L, Ding W, Sun H, Zhou Q, Huang J, Li X, Xie Y, Chen J.
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Salidroside protects PC12 cells from MPP(+)-induced apoptosis via activation of the PI3K/Akt pathway.
Food Chem Toxicol.
2012 Aug;50(8):2591-7.
(IF 4.679)
196. Zhang Q, He QF, Zhang TH, Yu XL, Liu Q, Deng FL.
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Improvement in the delivery system of bone morphogenetic protein-2: a new approach to promotebone formation.
Biomed Mater.
2012 Aug;7(4):045002.
(IF 3.174)
197. Fauzee NJ, Wang YL, Dong Z, Li QG, Wang T, Mandarry MT, Xu L, Pan J.
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Novel hydrophilic docetaxel (CQMU-0519) analogue inhibits proliferation and induces apoptosis inhuman A549 lung, SKVO3 ovarian and MCF7 breast carcinoma cell lines.
CELL PROLIFERAT.
2012 Aug;45(4):352-64.
(IF 5.753)
198. Lin N, Chen H, Zhang H, Wan X, Su Q.
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Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 betacell death.
Endocrine.
2012 Aug;42(1):107-17.
(IF 3.235)
199. Liu W, Li N.
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Chicken sine oculis binding protein homolog (sobp), a novel gene that may regulate feather development.
J POULT SCI.
2012 Aug;91(8):1950-5.
(IF 0.88)
200. Zhou H, Chen ZB, Tian HQ, Xu X, Wang YQ, Xing GQ, Cheng L.
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Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion.
ACTA OTO-LARYNGOL.
2012 Sep;132(9):938-43.
(IF 1.157)
201. Song Z, Liu L, Yue Y, Jiao H, Lin H, Sheikhahmadi A, Everaert N, Decuypere E, Buyse J.
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Fasting alters protein expression of AMP-activated protein kinase in the hypothalamus of broilerchicks (Gallus gallus domesticus).
GEN COMP ENDOCR.
2012 Sep 15;178(3):546-55.
(IF 2.426)
202. Liu H, Chen X, Gao W, Jiang G.
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The expression of heparanase and microRNA-1258 in human non-small cell lung cancer.
TUMOR BIOL .
2012 Oct;33(5):1327-34.
(IF 3.65)
203. Zhao P, Han T, Guo JJ, Zhu SL, Wang J, Ao F, Jing MZ, She YL, Wu ZH, Ye LB.
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HCV NS4B induces apoptosis through the mitochondrial death pathway.
Virus Res.
2012 Oct;169(1):1-7.
(IF 2.934)
204. Hu B, Zhou H, Gao H, Liu Y, Yan T, Zou L, Chen L.
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IFN-γ Inhibits Osteopontin Expression in Human Decidual Stromal Cells and can be Attenuated by 1α,25-Dihydroxyvitamin D3.
Am J Reprod Immunol.
2012 Oct;68(4):353-61.
(IF 2.739)
205. Zhang Y, Zhou L, Zhang X, Bai J, Shi M, Zhao G.
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Ginsenoside-Rd attenuates TRPM7 and ASIC1a but promotes ASIC2a expression in rats after focalcerebral ischemia.
Neurol Sci.
2012 Oct;33(5):1125-31.
(IF 2.415)
206. Bi WY, Fu BD, Shen HQ, Wei Q, Zhang C, Song Z, Qin QQ, Li HP, Lv S, Wu SC, Yi PF, Wei XB.
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Sulfated Derivative of 20(S)-Ginsenoside Rh2 Inhibits Inflammatory Cytokines Through MAPKs andNF-kappa B Pathways in LPS-Induced RAW264.7 Macrophages.
Inflammation.
2012 Oct;35(5):1659-68.
(IF 3.212)
207. Tian J, Yan J, Wang W, Zhong N, Tian L, Sun J, Min Z, Ma J, Lu S.
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T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2αpathway.
Toxicol In Vitro.
2012 Oct 26(7):1106-13.
(IF 2.959)
208. Chen X, Yang X, Liu T, Guan M, Feng X, Dong W, Chu X, Liu J, Tian X, Ci X, Li H, Wei J, Deng Y, Deng X, Chi G, Sun Z.
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Kaempferol regulates MAPKs and NF-κB signaling pathways to attenuate LPS-induced acute lunginjury in mice.
Int Immunopharmacol.
2012 Oct;14(2):209-16.
(IF 3.943)
209. Li XY, Jing CQ, Zang XY, Yang S, Wang JJ.
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Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride.
Toxicol In Vitro.
2012 Oct;26(7):1087-92.
(IF 2.959)
210. Ding Y, Huang X, Liu T, Fu Y, Tan Z, Zheng H, Zhou T, Dai J, Xu W.
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The Plasmodium Circumsporozoite Protein, a Novel NF-κB Inhibitor, Suppresses the Growth ofSW480.
Pathol Oncol Res.
2012 Oct;18(4):895-902.
(IF 2.826)
211. Zhu XB, Wang YB, Chen O, Zhang DQ, Zhang ZH, Cao AH, Huang SY, Sun RP.
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Characterization of the expression of macrophage inflammatory protein-1α (MIP-1α) andchemokine receptor CCR5 after kainic acid-induced status epilepticus (SE) in juvenile rats.
NEUROPATH APPL NEURO.
2012 Oct;38(6):602-16.
(IF 7.5)
212. Lu N, Liu Q, Li R, Xie L, Shen J, Guan W, Qian X, Yu L, Ding Y, Jiang X, Liu B.
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Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in amouse metastasis model.
ANTI-CANCER DRUG.
2012 Nov;23(10):1078-88.
(IF 2.26)
213. Zhou YM, Zhang XF, Cao L, Li B, Sui CJ, Li YM, Yin ZF
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MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma.
Liver Int.
2012 Nov;32(10):1505-9.
(IF 5.175)
214. Jia P, Xu YJ, Zhang ZL, Li K, Li B, Zhang W, Yang H.
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Ferric ion could facilitate osteoclast differentiation and bone resorption through the production ofreactive oxygen species.
J Orthop Res.
2012 Nov;30(11):1843-52.
(IF 2.728)
215. Tang X, Liu J, Dong W, Li P, Li L, Lin C, Zheng Y, Hou J, Li D.
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The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury.
EVID-BASED COMPL ALT.
2013;2013:820695.
(IF 1.813)
216. Liu X, Wang M, Chen H, Guo Y, Ma F, Shi F, Bi Y, Li Y.
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Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response-induced apoptosis through CHOP.
PLoS One.
2013;8(1):e53431.
(IF 2.74)
217. Jin R, Zhu W, Cao S, Chen R, Jin H, Liu Y, Wang S, Wang W, Xiao G.
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Japanese encephalitis virus activates autophagy as a viral immune evasion strategy.
PLoS One.
2013;8(1):e52909.
(IF 2.74)
218. Feng Q, Gou XJ, Meng SX, Huang C, Zhang YQ, Tang YJ, Wang WJ, Xu L, Peng JH, Hu YY.
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Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivoand In Vitro.
EVID-BASED COMPL ALT.
2013;2013:184358.
(IF 1.813)
219. Zhang L, Xiao R, Xiong J, Leng J, Ehtisham A, Hu Y, Ding Q, Xu H, Liu S, Wang J, Tang DG, Zhang Q.
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Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.
PLoS One.
2013;8(1):e52384.
(IF 2.74)
220. Hu L, Wu QQ, Wang WB, Jiang HG, Yang L, Liu Y, Yu HJ, Xie CH, Zhou YF, Zhou FX.
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Suppression of Ku80 Correlates with Radiosensitivity and Telomere Shortening in the U2OS Telomerase-negativeOsteosarcoma Cell Line.
ASIAN PAC J CANCER P .
2013;14(2):795-9.
(IF 1.24)
221. Wang M, Wang J, Tan R, Wu Q, Qiu H, Yang J, Jiang Q.
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Effect of Berberine on PPAR α /NO Activation in High Glucose- and Insulin-Induced Cardiomyocyte Hypertrophy.
EVID-BASED COMPL ALT.
2013;2013:285489.
(IF 1.813)
222. Chen X, Gu M, Zhao X, Zheng X, Qin Y, You X.
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Deterioration of cardiac function after acute myocardial infarction is prevented by transplantation of modified endothelial progenitor cells overexpressing endothelial NO synthases.
CELL PHYSIOL BIOCHEM.
2013;31(2-3):355-65.
(IF 5.5)
223. Gao M, Wu M, Song Y, Jin L, Lou J, Tao H.
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PCB153-induced oxidative stress and cell apoptosis on cultured rat Sertoli cells.
Toxicology Research.
2013;3:173-9.
(IF 1.593)
224. Lian LH, Jin Q, Song SZ, Wu YL, Bai T, Jiang S, Li Q, Yang N, Nan JX.
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Ginsenoside Rh2 Downregulates LPS-Induced NF- κ B Activation through Inhibition of TAK1 Phosphorylation inRAW 264.7 Murine Macrophage.
EVID-BASED COMPL ALT.
2013;2013:646728.
(IF 1.813)
225. Liu Z, Zhang J, Huang X, Huang L, Li S, Wang Z.
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Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro.
J Surg Res.
2013 Jan;179(1):e189-95.
(IF 1.841)
226. Zhu C, Wang Q, Xie J, Shi J, Zhou X, Li D, Xiong F, Zhang L.
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Expression and Significance of RKIP and E-cadherin in Lung Squamous Cell Carcinoma.
Pathol Oncol Res.
2013 Jan;19(1):19-26.
(IF 2.826)
227. Qiu L, Chen Y, Gao M, Zheng C, Zhao Q.
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Phagocytic uptake and ROS-mediated cytotoxicity in human hepatic cell line of amphiphilic polyphosphazenenanoparticles.
J Biomed Mater Res A.
2013 Jan;101(1):285-97.
(IF 3.525)
228. Tang XQ, Zhuang YY, Zhang P, Fang HR, Zhou CF, Gu HF, Zhang H, Wang CY.
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Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in thehippocampus of rats.
J Mol Neurosci.
2013 Jan;49(1):140-9.
(IF 2.678)
229. Zou Y, Hong B, Fan L, Zhou L, Liu Y, Wu Q, Zhang X, Dong M.
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Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway.
FREE RADICAL RES.
2013 Jan;47(1):55-63.
(IF 2.839)
230. Ding J, Li QY, Yu JZ, Wang X, Lu CZ, Ma CG, Xiao BG.
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Carbamylated erythropoietin ameliorates hypoxia-induced cognitive and behavioral defects with the generation ofcholine acetyltransferase-positive neurons.
J Neurosci Res.
2013 Jan;91(1):73-82.
(IF 4.699)
231. Gu Y, Zhao Y, Gong L, Wang Y, Zhang Y.
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Potassium aspartate attenuates apoptotic cell death after focal cerebral ischemia in rats.
Biomedicine & Aging Pathology.
2013 Jan-Mar;3(1):14–19.
232. Duan S, Yang X, Mao J, Qi B, Cai Q, Shen H, Yang F, Deng X, Wang S.
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Osteocompatibility evaluation of poly(glycine ethyl ester-co-alanine ethyl ester)phosphazene with honeycomb-patterned surface topography.
J Biomed Mater Res A.
2013 Feb;101(2):307-17.
(IF 3.525)
233. Jia F, Fan J, Zhang B, Yuan Z.
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Mutagenesis of D80-82 and G83 residues in West Nile Virus NS2B: effects on NS2B-NS3 activity and viralreplication.
Virol Sin.
2013 Feb;28(1):16-23.
(IF 3.242)
234. Chen Y, Huang C, Bai C, Gao H, Ma R, Liu X, Dong Q.
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Benzo[α]pyrene repressed DNA mismatch repair in human breast cancer cells.
Toxicology.
2013 Feb 8;304:167-72.
(IF 4.099)
235. Xie B, Zhou J, Shu G, Liu DC, Zhou J, Chen J, Yuan L.
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Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumorsuppressive role of klotho in gastric cancer.
Cancer Cell Int.
2013 Feb 21;13(1):18.
(IF 4.175)
236. Bai T, Lian LH, Wu YL, Wan Y, Nan JX.
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Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells.
Int Immunopharmacol.
2013 Feb;15(2):275-81.
(IF 3.943)
237. Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J, Cheng H, Chen L.
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Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction.
Dev Biol.
2013 Mar 1;375(1):13-22.
(IF 2.895)
238. Zhang H, Wang ZW, Wu HB, Li Z, Li LC, Hu XP, Ren ZL, Li BJ, Hu ZP.
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Transforming growth factor-β1 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cellsvia ROS-dependent ERK-NF-κB pathways.
Mol Cell Biochem.
2013 Mar;375(1-2):11-21.
(IF 2.795)
239. Dong X, Wang G, Zhang G, Ni Z, Suo J, Cui J, Cui A, Yang Q, Xu Y, Li F.
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The endothelial lipase protein is promising urinary biomarker for diagnosis of gastric cancer.
Diagn Pathol.
2013 Mar 19;8:45.
(IF 2.335)
240. Yang T, Li C, Zhang L, Li M, Zhou P.
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A promising hepatocyte-like cell line, CCL-13, exhibits good liver function both in vitro and in an acute liver failuremodel.
TRANSPL P.
2013 Mar;45(2):688-94.
(IF 0.784)
241. Sui Z, Yuan H, Liang Z, Zhao Q, Wu Q, Xia S, Zhang L, Huo Y, Zhang Y.
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An activity-maintaining sequential protein extraction method for bioactive assay and proteome analysis of velvetantlers.
Talanta.
2013 Mar 30;107:189-94.
(IF 5.339)
242. Hu X, Yang T, Li C, Zhang L, Li M, Huang W, Zhou P.
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Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model.
TRANSPL P.
2013 Mar;45(2):695-700.
(IF 0.784)
243. Jin J, Zhao WC, Yuan F.
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CXCR7/CXCR4/CXCL12 Axis Regulates the Proliferation, Migration, Survival and Tube Formation of Choroid-Retinal Endothelial Cells.
Ophthalmic Res.
2013 Mar 21;50(1):6-12.
(IF 1.961)
244. Yin Y, Liu W, Ji G, Dai Y.
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The essential role of p38 MAPK in mediating the interplay of oxLDL and IL-10 in regulating endothelial cellapoptosis.
Eur J Cell Biol.
2013 Apr-May;92(4-5):150-9.
(IF 3.025)
245. Jia QA, Wang ZM, Ren ZG, Bu Y, Xie XY, Wang YH, Zhang L, Zhang QB, Xue TC, Deng LF, Tang ZY.
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Herbal compound "Songyou Yin" attenuates hepatoma cell invasiveness and metastasis through downregulationof cytokines secreted by activated hepatic stellate cells.
BMC COMPLEM ALTERN M.
2013 Apr 27;13:89.
(IF 2.833)
246. ITan Z, Zhu R, Shi R, Zhong J, Ma Y, Wang C, Wang X, Cheng N.
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Involvement of rat organic cation transporter 2 in the renal uptake of jatrorrhizine.
EUR J PHARM SCI.
2013 Apr;102(4):1333-42.
(IF 3.616)
247. Hu J, Wu Q, Li T, Chen Y, Wang S.
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Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Exp Eye Res.
2013 Apr;109:31-9.
(IF 3.011)
248. Wang J, Cui J, Zhu H.
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Suppression of type I collagen in human scleral fibroblasts treated with extremely low-frequency electromagneticfields.
Mol Vis.
2013 Apr 12;19:885-93.
(IF 2.202)
249. Wang Y, Li B, Li Z, Huang S, Wang J, Sun R.
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Improvement of hypoxia-ischemia-induced white matter injury in immature rat brain by ethyl pyruvate.
Neurochem Res.
2013 Apr;38(4):742-52.
(IF 3.038)
250. He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD.
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Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.
IMMUNOPHARM IMMUNOT.
2013 Apr;35(2):215-24.
(IF 2.352)
251. Tang Z, Wu M, Li Y, Zheng X, Liu H, Cheng X, Xu L, Wang G, Hao H.
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Absolute quantification of NAD(P)H:quinone oxidoreductase 1 in human tumor cell lines and tissues by liquid chromatography-mass spectrometry/mass spectrometry using both isotopic and non-isotopic internal standards.
Anal Chim Acta.
2013 Apr 15;772:59-67.
(IF 5.977)
252. Huo K, Zhang X, Wang H, Zhao L, Liu X, Chu PK.
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Osteogenic activity and antibacterial effects on titanium surfaces modified with Zn-incorporated nanotube arrays.
Biomaterials.
2013 Apr;34(13):3467-78.
(IF 10.317)
253. Yan W, Zhang H, Liu P, Wang H, Liu J, Gao C, Liu Y, Lian K, Yang L, Sun L, Guo Y, Zhang L, Dong L, Lau WB, Gao E, Gao F, Xiong L, Wang H, Qu Y, Tao L.
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Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing toincreased vulnerability in diabetic heart.
Basic Res Cardiol.
2013 May;108(3):329.
(IF 11.981)
254. Yu SY, Zhang M, Luo J, Zhang L, Shao Y, Li G.
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Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.
PROG NEURO-PSYCHOPH.
2013 May 8;45C:47-53.
(IF 4.361)
255. Wang J, Zeng L, Zhou Q, Xu Y, Pu S, Jiang W, Zhang X, Du D.
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L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAPon ipsilateral dorsal horn.
ACTA NEUROCHIR.
2013 May;155(5):935-40.
(IF 1.817)
256. Jing J, Liu H, Chen H, Hu S, Xiao K, Ma X.
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Acute effect of copper and cadmium exposure on the expression of heat shock protein 70 in the Cyprinidae fishTanichthys albonubes.
Chemosphere.
2013 May;91(8):1113-22.
(IF 5.778)
257. Wei Q, Shi F.
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Cleavage of poly (ADP-ribose) polymerase-1 is involved in the process of porcine ovarian follicular atresia.
Anim Reprod Sci.
2013 May;138(3-4):282-91.
(IF 1.66)
258. Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H, Xie WP.
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Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats.
Int Immunopharmacol.
2013 May;16(1):7-16.
(IF 3.943)
259. Yan M, Shi Y, Wang Y, Wang C, Zhou J, Quan C, Liu C, Yang K.
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Effects of p,p'-DDE on the mRNA and protein expressions of vimentin, N-cadherin and FSHR in rats testes: an invivo and in vitro study.
ENVIRON TOXICOL CHEM.
2013 May;35(3):486-94.
(IF 3.152)
260. Yi PF, Bi WY, Shen HQ, Wei Q, Zhang LY, Dong HB, Bai HL, Zhang C, Song Z, Qin QQ, Lv S, Wu SC, Fu BD, Wei XB.
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Inhibitory effects of sulfated 20(S)-ginsenoside Rh2 on the release of pro-inflammatory mediators in LPS-inducedRAW 264.7 cells.
Eur J Pharmacol.
2013 May 9;712(1-3):60-66.
(IF 3.263)
261. Han HY, Zhu SH, Jiang LL, Li Y, Dong H, Zhao QP, Kong CL, Huang B.
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Molecular characterization and analysis of a novel calcium-dependent protein kinase from Eimeria tenella.
Parasitology.
2013 May;140(6):746-55.
(IF 2.783)
262. Xie N, Wang C, Lian Y, Zhang H, Wu C, Zhang Q.
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A selective inhibitor of Drp1, mdivi-1, protects against cell death of hippocampal neurons in pilocarpine-inducedseizures in rats.
Neurosci Lett.
2013 Jun 17;545:64-8.
(IF 2.274)
263. Yue Y, Yang X, Wei X, Chen J, Fu N, Fu Y, Ba K, Li G, Yao Y, Liang C, Zhang J, Cai X, Wang M.
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Osteogenic differentiation of adipose-derived stem cells prompted by low-intensity pulsed ultrasound.
CELL PROLIFERAT.
2013 Jun;46(3):320-7.
(IF 5.753)
264. Chen N, Wu Q, Chi G, Soromou LW, Hou J, Deng Y, Feng H.
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Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice.
Int Immunopharmacol.
2013 Jun;16(2):139-47.
(IF 3.943)
265. Tang L, Ma X, Tian Q, Cheng Y, Yao H, Liu Z, Qu X, Han X.
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Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Aktpathway in MDA-MB-231 breast cancer cells.
Food Chem Toxicol.
2013 Jun;56:204-13.
(IF 4.679)
266. Hong JP, Li XM, Li MX, Zheng FL.
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VEGF suppresses epithelial-mesenchymal transition by inhibiting the expression of Smad3 and miR-192, aSmad3-dependent microRNA.
Int J Mol Med.
2013 Jun;31(6):1436-42.
(IF 3.098)
267. Yan Y, Liu H, Wen H, Jiang X, Cao X, Zhang G, Liu G.
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The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells.
Mol Cell Biochem.
2013 Jun;378(1-2):1-7.
(IF 2.795)
268. Zou M, Xia S, Zhuang L, Han N, Chu Q, Chao T, Peng P, Chen Y, Gui Q, Yu S.
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Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancercell line harboring T790M mutation.
Int J Oncol.
2013 Jun;42(6):2094-102.
(IF 3.899)
269. Xue H, Zhang XY, Liu JM, Song Y, Liu TT, Chen D.
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NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects.
Brain Res.
2013 Jun 21;1516:83-92.
(IF 2.733)
270. Li L, Ye XP, Lu AZ, Zhou SQ, Liu H, Liu ZJ, Jiang S, Xu SY.
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Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction andendoplasmic reticulum stress.
J Neurosci Res.
2013 Jun;91(6):786-98.
(IF 4.699)
271. Zhang E, Yan X, Zhang M, Chang X, Bai Z, He Y, Yuan Z.
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Aggrecanases in the human synovial fluid at different stages of osteoarthritis.
Clin Rheumatol.
2013 Jun;32(6):797-803.
(IF 2.394)
272. Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.
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Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.
J Cell Physiol.
2013 Jun;228(6):1238-48.
(IF 5.546)
273. Li X, Wang X, Han C, Wang X, Xing G, Zhou L, Li G, Niu Y.
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Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediatedp38 MAPK pathway.
FREE RADICAL BIO MED.
2013 Jul;60:168-76.
(IF 6.17)
274. Zhang JX, Yang JR, Chen GX, Tang LJ, Li WX, Yang H, Kong X.
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Sesamin ameliorates arterial dysfunction in spontaneously hypertensive rats via downregulation of NADPHoxidase subunits and upregulation of eNOS expression.
Acta Pharmacol Sin.
2013 Jul;34(7):912-20.
(IF 5.064)
275. Tang Y, Wang YL, Yang L, Xu JX, Xiong W, Xiao M, Li M.
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Inhibition of arginine ADP-ribosyltransferase 1 reduces the expression of poly(ADP-ribose) polymerase-1 in coloncarcinoma.
Int J Mol Med.
2013 Jul;32(1):130-6.
(IF 3.098)
276. Qing Y, Liang Y, Du Q, Fan P, Xu H, Xu Y, Shi N.
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Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways.
Arch Toxicol.
2013 Jul;87(7):1273-85.
(IF 5.059)
277. Zhou D, Wei A, Cao C, Ruan J.
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DICO, a novel nonaromatic B-ring flavonoid, induces G2/M cell cycle arrest and apoptosis in human hepatomacells.
Food Chem Toxicol.
2013 Jul;57:322-9.
(IF 4.679)
278. Qin D, Li K, Qu J, Wang S, Zou C, Sheng Y, Huang A, Tang H.
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HBx and HBs regulate RhoC expression by upregulating transcription factor Ets-1.
Arch Virol.
2013 Aug;158(8):1773-81.
(IF 2.243)
279. Chen S, Lin G, Lei L, You X, Wu C, Xu W, Huang M, Luo L, Wang Z, Li Y, Zhao X, Yan F.
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Hyperlipidemia Modifies Innate Immune Responses to Lipopolysaccharide via the TLR-NF-κB Signaling Pathway.
Inflammation.
2013 Aug;36(4):968-76.
(IF 3.212)
280. Qiu X, Cao L, Yang X, Zhao X, Liu X, Han Y, Xue Y, Jiang H, Chi Z.
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Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats.
Neuroscience.
2013 Aug 15;245:157-65.
(IF 3.056)
281. Liu YW, Zhu X, Yang QQ, Lu Q, Wang JY, Li HP, Wei YQ, Yin JL, Yin XX.
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Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline inrats.
PSYCHOPHARMACOLOGY.
2013 Aug;228(4):585-94.
(IF 3.13)
282. Yan T, Liu Y, Cui K, Hu B, Wang F, Zou L.
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MiR-126 regulates EPCs function: implications for a role of miR-126 in preeclampsia.
J Cell Biochem.
2013 Sep;114(9):2148-59.
(IF 4.237)
283. Xu T, Wang X, Chen G, He Y, Bie P.
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Autologous bone marrow stem cell transplantation attenuates hepatocyte apoptosis in a rat model of ex vivo liver resection and liver autotransplantation.
Journal of Surgical Research.
2013 Oct;184(2):1102-8.
(IF 1.872)
284. Li LL, Wang H.
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Enzyme-Coated Mesoporous Silica Nanoparticles as Efficient Antibacterial Agents In Vivo.
Adv Healthc Mater.
2013 Oct;2(10):1351-60.
(IF 7.367)
285. Zheng XF, Li B, Zhang YH, Yang YH, Meng XY, Jiang SD, Jiang LS.
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Blockade of substance P receptor attenuates osteoporotic pain, but not bone loss, in ovariectomized mice.
Menopause.
2013 Oct;20(10):1074-83.
(IF 3.305)
286. Jin M, Zhang L, Yu H, Meng J, Sun Z, Lu R.
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Protective effect of whey protein hydrolysates on H2O2-induced PC12 cells oxidative stress via a mitochondria-mediated pathway.
Food Chemistry.
2013 Nov 15;141(2):847–852.
(IF 5.399)
287. Wang Q, Luo C, Wu X, Du H, Song X, Fan Y.
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305. Cao Q, Jiang Y, Shi J, Xu C, Liu X, Yang T, Fu P, Niu T.
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309. Wang J, Chen L, Li H, Yang J, Gong Z, Wang B, Zhao X.
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Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation.
BASIC CLIN PHARMACOL.
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317. Wu J, Li H, Sun X, Zhang H, Hao S, Ji M, Yang J, Li K.
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319. Wang D, Shi J, Lv S, Xu W, Li J, Ge W, Xiao C, Geng D, Liu Y.
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Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR, MyD88 Expression, and NF-κB Activation in Microglial Cells.
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321. Zhu D, Wang H, Zhang J, Zhang X, Xin C, Zhang F, Lee Y, Zhang L, Lian K, Yan W, Ma X, Liu Y, Tao L5.
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322. Chen O, Ye Z, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W, Sun X.
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Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.
FREE RADICAL BIO MED.
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323. Ailijiang N, Chang J, Liang P, Li P, Wu Q, Zhang X, Huang X.
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BIORESOURCE TECHNOL.
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324. Wang G, Kang N, Gong H, Luo Y, Bai C, Chen Y, Ji X, Huang C, Dong Q.
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Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish.
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325. Chen L, Mao F, Kirumba GC, Jiang C, Manefield M, He Y.
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ECOTOX ENVIRON SAFE.
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327. You J, Wang Z, Xu S, Zhang W, Fang Q, Liu H, Peng L, Deng T, Lou J .
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HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells
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329. Wang L, He Y, Zhang Y, Zhou H, Yu L, Yang J, Wan H.
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330. Guo YJ, Liu JX, Guan YW.
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EUR REV MED PHARMACO.
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331. Li R, Wang Y, Zhao E, Wu K, Li W, Shi L, Wang D, Xie G, Yin Y, Deng M, Zhang P, Tao K .
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Oxid Med Cell Longev.
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Oxid Med Cell Longev.
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333. Bai J, Zheng Y, Wang G, Liu P.
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Oxid Med Cell Longev.
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334. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ.
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Knockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells.
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EUR REV MED PHARMACO.
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339. Li L, Liu HC, Wang C, Liu X, Hu FC, Xie N, Lü L, Chen X, Huang HZ.
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MicroRNA-197 Mediates the Overgrowth and Anti-Apoptotic Effects by Downregulating Insulin-Like GrowthFactor-Binding Protein-3 During Nephroblastoma Tumorigenesis.
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Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NO/cGMPSignaling Pathway in Rats.
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Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
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Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell bySuppressing Canonical NF-κB Signaling.
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356. Hu H, Xuan Y, Xue M, Cheng W, Wang Y, Li X, Yin J, Li X, Yang N, Shi Y, Yan S.
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Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 inVascular Endothelial Cells.
SCI REP-UK.
2016 Feb 18;6:21620.
(IF 3.998)
382. Chen Z, Xue J, Shen T, Ba G, Yu D, Fu Q .
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Curcumin alleviates glucocorticoid-induced osteoporosis by protecting osteoblasts from apoptosis in vivoand in vitro.
CLIN EXP PHARMACOL P .
2016 Feb;43(2):268-76.
(IF 2.092)
383. Wang X, He G, Mai K, Xu W, Zhou H.
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Differential regulation of taurine biosynthesis in rainbow trout and Japanese flounder.
SCI REP-UK.
2016 Feb 16;6:21231.
(IF 3.998)
384. Chen D, Yan W, Liu Z, Zhang Z, Zhu L, Liu W, Ding X, Wang A, Chen Y .
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Downregulation of miR-221 enhances the sensitivity of human oral squamous cell carcinoma cells toAdriamycin through upregulation of TIMP3 expression.
Biomed Pharmacother.
2016 Feb;77:72-8.
(IF 4.545)
385. Wu H, Liu J, Li W, Liu G, Li Z.
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LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activatingNF-κB pathway.
BIOCHEM BIOPH RES CO.
2016 Feb 26;471(1):240-6.
(IF 2.985)
386. Yuan L, Sui T, Chen M, Deng J, Huang Y, Zeng J, Lv Q, Song Y, Li Z, Lai L.
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CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts.
SCI REP-UK.
2016 Feb 25;6:22024.
(IF 3.998)
387. Zhang R, Li L, Yuan L, Zhao M.
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Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
Exp Mol Pathol.
2016 Feb;100(1):51-8.
(IF 2.28)
388. Huang W, Liu Z, Zhou G, Tian A, Sun N .
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Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy.
Oncol Rep.
2016 Feb;35(2):978-84.
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389. Zhong J, Li X, Wan L, Chen Z, Zhong S, Xiao S, Yan Z .
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Knockdown of NogoA prevents MPP+-induced neurotoxicity in PC12 cells via the mTOR/STAT3 signalingpathway.
Mol Med Rep.
2016 Feb;13(2):1427-33.
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390. Zhang R, Li L, Yuan L, Zhao M .
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Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis viasphingosine kinase 2 and FAK/AKT pathway.
Exp Mol Pathol.
2016 Feb;100(1):51-8.
(IF 2.28)
391. Zhao Y, Tan K, Zhou Y, Ye Z, Tan WS .
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A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(ε-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells.
MAT SCI ENG C-MATER.
2016 Feb;59:193-202.
(IF 5.88)
392. Zhang K, Liu J, You X, Kong P, Song Y, Cao L, Yang S, Wang W7, Fu Q, Ma Z .
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P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice.
Neurosci Lett.
2016 Feb 2;613:60-5.
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393. Xu T, Zong Y, Peng L, Kong S, Zhou M, Zou J, Liu J, Miao R, Sun X, Li L .
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Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis.
ONCOTARGETS THER.
2016 Feb 19;9:815-22.
(IF 3.337)
394. Chen Z, Xue J, Shen T, Mu S, Fu Q.
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Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt
Int J Mol Med.
2016 Feb;37(2):329-38.
(IF 3.098)
395. Li H, Zhang C, Cui H, Guo K, Wang F, Zhao T, Liang W, Lv Q, Zhang Y .
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FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication.
Virus Genes.
2016 Feb;52(1):99-106.
(IF 1.991)
396. Zhang W, Tong D, Liu F, Li D, Li J, Cheng X, Wang Z .
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RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis.
ONCOTARGET.
2016 Feb 2;7(5):5800-14.
(IF 5.168)
397. Chen L, Guan H, Gu C, Cao Y, Shao J, Wang F .
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miR-383 inhibits hepatocellular carcinoma cell proliferation via targeting APRIL.
TUMOR BIOL .
2016 Feb;37(2):2497-507.
(IF 3.65)
398. He B, Xiao YF, Tang B, Wu YY, Hu CJ, Xie R, Yang X, Yu ST, Dong H, Zhao XY, Li JL, Yang SM.
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hTERT mediates gastric cancer metastasis partially throughthe indirect targeting of ITGB1 by microRNA-29a.
SCI REP-UK.
2016 Feb 23;6:21955.
(IF 3.998)
399. Zhang L, Gan X, Zhu Z, Yang Y, He Y, Yu H .
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Reactive oxygen species regulatory mechanisms associated with rapid response of MC3T3-E1 cells for vibration stress.
BIOCHEM BIOPH RES CO.
2016 Feb 12;470(3):510-5.
(IF 2.985)
400. Wang X, Chen X, Yang X, Gao W, He B, Dai W, Zhang H, Wang X, Wang J, Zhang X, Dai Z, Zhang Q.
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A nanomedicine based combination therapy based on QLPVM peptide functionalized liposomaltamoxifenand doxorubicin against Luminal A breast cancer.
Nanomedicine.
2016 Feb;12(2):387-97.
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401. Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P, Liu Q .
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Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death.
SCI REP-UK.
2016 Feb 18;6:21018.
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402. Yu W, Gao XJ, Liu Y, Wang Q.
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Fusion expression of cecropin B-like antibacterial peptide in Pichia GS115 and its antibacterial
Biotechnol Lett.
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403. Dong YF, Chen ZZ, Zhao Z, Yang DD, Yan H, Ji J, Sun XL.
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Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced byoxygen-glucose deprivation.
J NEUROINFLAMM.
2016 Mar 9;13(1):60.
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404. Zhang D, Fei Q, Li J, Zhang C, Sun Y, Zhu C, Wang F, Sun Y .
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2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro.
PLoS One.
2016 Mar 3;11(3):e0151115.
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405. Weifeng Y, Li L, Yujie H, Weifeng L, Zhenhui G, Wenjie H .
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Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative StressPathway.
PLoS One.
2016 Mar 18;11(3):e0151672.
(IF 2.74)
406. Cao Z, Fu Y, Sun X, Zhang Q, Xu F, Li Y .
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Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signalingpathway in rat osteoblasts.
ENVIRON TOXICOL CHEM.
2016 Mar;42:198-204.
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407. Liu B, Li T, Peng JJ, Zhang JJ, Liu WQ, Luo XJ, Ma QL, Gong ZC, Peng J .
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Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction inpulmonary hypertensive rats through up-regulation of NADPH oxidase.
Eur J Pharmacol.
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408. Miao L, Xin X, Xin H, Shen X, Zhu YZ .
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Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in MyocardialInfarction.
SCI REP-UK.
2016 Mar 2;6:22363.
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409. Wang X, Chen E, Yang X, Wang Y, Quan Z, Wu X, Luo C .
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5-azacytidine inhibits the proliferation of bladder cancer cells via reversal of the aberrant hypermethylationof the hepaCAM gene.
Oncol Rep.
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410. Ju H, Yang Y, Sheng A, Qi Y.
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MicroRNA-378 promotes myogenic differentiation by targeting BMP4.
Mol Med Rep.
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411. Ren X, Wang L, Wu X .
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A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cellsfor Aspergillus fumigatus tolerance.
Mol Immunol.
2016 Mar;71:98-106.
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412. Fu X, Pang X, Qi H, Chen S, Li Y, Tan W.
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XIAP inhibitor Embelin inhibits bladder cancer survival and invasion in vitro.
Clin Transl Oncol.
2016 Mar;18(3):277-82.
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413. Jiao Y, Ma S, Wang Y, Li J, Shan L, Sun J, Chen J .
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Methacryloxylethyl Cetyl Ammonium Chloride Induces DNA Damage and Apoptosis in Human Dental PulpCells via Generation of Oxidative Stress.
Int J Biol Sci.
2016 Mar 21;12(5):580-93.
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414. Cai ZZ, Xu JG, Zhou YH, Zheng JH, Lin KZ, Zheng SZ, Ye MS, He Y, Liu CB, Xue ZX .
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Human cytomegalovirus-encoded US28 may act as a tumor promoter in colorectal cancer.
WORLD J GASTROENTERO.
2016 Mar 7;22(9):2789-98.
(IF 3.665)
415. Liu HZ, Wang QY, Zhang Y, Qi DT, Li MW, Guo WQ, Ma YH, Wang LY, Chen Y, Gao CY.
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Pioglitazone up-regulates long non-coding RNA MEG3 to protect endothelial progenitor cells via increasingHDAC7 expression in metabolic syndrome.
Biomed Pharmacother.
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416. Zhu Y, Zhao H, Feng L, Xu S.
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MicroRNA-217 inhibits cell proliferation and invasion by targeting Runx2 in human glioma.
Am J Transl Res.
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417. Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML, Fan H.
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HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 andrepressingp27Kip1/CDK2 signaling.
SCI REP-UK.
2016 Mar 24;6:23521.
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418. Wang YP, Song GH, Chen J, Xiao C, Li C, Zhong L, Sun X, Wang ZW, Deng GL, Yu FD, Xue YM, Tang HM, Peng ZH, Wang XL.
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Elevated OCT1 participates in colon tumorigenesis and independently predicts poor prognoses ofcolorectal cancer patients.
TUMOR BIOL .
2016 Mar;37(3):3247-55.
(IF 3.65)
419. Du L, Lv R, Yang X, Cheng S, Ma T, Xu J.
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Hypoxic conditioned medium of placenta-derived mesenchymal stem cells protects against scar formation.
Life Sci.
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420. Ma Y, Gai Y, Yan J, Li J, Zhang Y.
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Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3Expression, a Modulator of Apoptosis and Autophagy.
MED SCI MONITOR.
2016 Mar 24;22:977-83.
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421. Li TB, Zhang JJ, Liu B, Liu WQ, Wu Y, Xiong XM, Luo XJ, Ma QL, Peng J.
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Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitorcells in hyperlipidemia.
N-S ARCH PHARMACOL.
2016 Mar;389(3):289-302.
(IF 2.05)
422. Zhou J, Li W, Guo J, Li G, Chen F, Zhou J .
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Downregulation of miR-329 promotes cell invasion by regulating BRD4 and predicts poor prognosis inhepatocellular carcinoma.
TUMOR BIOL .
2016 Mar;37(3):3561-9.
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423. Kong L, Guo S, Liu C, Zhao Y, Feng C, Liu Y, Wang T, Li C .
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Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
Int J Oncol.
2016 Mar;48(3):1085-94.
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424. Dong Z, Tai W, Lei W, Wang Y, Li Z, Zhang T.
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IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells.
BMC Cell Biol.
2016 Mar 1;17:7.
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425. Tian Y, Guo R, Shi B, Chen L, Yang L, Fu Q.
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MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.
Life Sci.
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426. Ji K, Xue L, Cheng J, Bai Y.
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Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction ofHSP70 through PI3K/Akt/Nrf2 pathway.
Brain Res Bull.
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(IF 3.37)
427. Wu D, Zhang J, Wang J, Li J, Liao F, Dong W .
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Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by theincreased intracellular reactive oxygen species.
TUMOR BIOL .
2016 Mar;37(3):3451-9.
(IF 3.65)
428. Chu W, Wei W, Yu S, Han H, Shi X, Sun W, Gao Y, Zhang L, Chen J .
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C2C12 myotubes inhibit the proliferation and differentiation of 3T3-L1 preadipocytes by reducing theexpression of glucocorticoid receptor gene.
BIOCHEM BIOPH RES CO.
2016 Mar 25;472(1):68-74.
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429. KoraMagazi A, Wang D, Yousef B, Guerram M, Yu F .
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Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calciumin primary human hepatic HL-7702 cells.
BIOCHEM BIOPH RES CO.
2016 Apr 22;473(1):230-6.
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430. Wang X, Guo H, Liu W, Yang C, Yang L, Wang D, Wang X.
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Effects of siRNA-Mediated Knockdown of HDAC1 on the Biological Behavior of Esophageal Carcinoma CellLines.
MED SCI MONITOR.
2016 Apr 18;22:1291-6.
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431. Wang N, Wei H, Yin D, Lu Y, Zhang Y, Zhang Q, Ma X, Zhang S.
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MicroRNA-195 inhibits proliferation of cervical cancer cells by targeting cyclin D1a.
TUMOR BIOL .
2016 Apr;37(4):4711-20.
(IF 3.65)
432. Wang X, Liang Z, Hou J, Bao X, Shen Y.
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Identification and functional evaluation of the reductases and dehydrogenases from
BMC Biotechnol.
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433. Li J, Qiu D, Chen Z, Du W, Liu J, Mo X .
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Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation offoxp3 expression in Jurkat cells.
Immunol Lett.
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434. Jiang Q, Liu Y, Duan D, Gou M, Wang H, Wang J, Li Q, Xiao R .
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Anti-angiogenic activities of CRBGP from buccal glands of lampreys (Lampetra japonica).
Biochimie.
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435. Shang H, Sun J, Chen YQ .
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Clostridium Butyricum CGMCC0313.1 Modulates Lipid Profile, Insulin Resistance and Colon Homeostasis inObese Mice.
PLoS One.
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436. Zhou Y, Wang Y, Li Y, Nick N, Zou X, Bai F, Wu J, Xin J .
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P19 contributes to Mycoplasma mycoides subsp. mycoides adhesion to EBL cells.
MICROB PATHOGENESIS.
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437. Wang X, Xu W, Fan M, Meng T, Chen X, Jiang Y, Zhu D7, Hu W, Gong J, Feng S, Wu J, Li Y .
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Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway.
ENVIRON TOXICOL CHEM.
2016 Apr;43:193-202.
(IF 3.152)
438. Zhang S, Li J, Zhou G, Mu D, Yan J, Xing J, Yao Z, Sheng H, Li D, Lv C, Sun B, Hong Q, Guo H .
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Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladdercancer.
TUMOR BIOL .
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(IF 3.65)
439. Wu S, Zhang G, Li P, Chen S, Zhang F, Li J, Jiang C, Chen X, Wang Y, Du Y, Sun Q, Zhao G.
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miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.
TUMOR BIOL .
2016 Apr;37(4):5193-202.
(IF 3.65)
440. Gan F, Hu Z, Huang Y, Xue H, Huang D, Qian G, Hu J, Chen X, Wang T, Huang K.
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Overexpression of pig selenoprotein S blocks OTA-induced promotion of PCV2 replication by inhibiting oxidative stress and p38 phosphorylation in PK15 cells.
ONCOTARGET.
2016 Apr 12;7(15):20469-85.
(IF 5.168)
441. Bi Y, Cao J, Jin S, Lv L, Qi L, Liu F, Geng J, Yu Y .
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Interleukin-22 promotes lung cancer cell proliferation and migration via the IL-22R1/STAT3 and IL-22R1/AKTsignaling pathways.
Mol Cell Biochem.
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442. Wang Y, Zhang B, Liu W, Dai Y, Shi Y, Zeng Q, Wang F .
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Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation ofreactive oxygen species.
ONCOTARGET.
2016 Apr 19;7(16):22355-67.
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443. Peng Z, Zhang Y .
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Propofol inhibits proliferation and accelerates apoptosis of human gastric cancer cells by regulation ofmicroRNA-451 and MMP-2 expression.
GENET MOL RES.
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444. Zhang Y, Liu C, Wang J, Li Q, Ping H, Gao S, Wang P.
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MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity inAPPswe/PS1dE9 mice.
SCI REP-UK.
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445. Jiang K, Zhuang Y, Yan M, Chen H, Ge AQ, Sun L, Miao B.
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Effects of riluzole on P2X7R expression in the spinal cord in rat model of neuropathic pain.
Neurosci Lett.
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446. Tao W, Wang H, Su Q, Chen Y, Xue W, Xia B, Duan J, Chen G.
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Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice.
Psychiatry Res.
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447. Zhang Y, Lei W, Yan W, Li X, Wang X, Zhao Z, Hui J, Shen Z, Yang J .
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microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targetingPim-1 kinase.
Stem Cell Res Ther.
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448. Su H, Jin X, Shen L, Fang Y, Fei Z, Zhang X, Xie C, Chen X .
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Inhibition of cyclin D1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymaltransition for esophageal cancer cells.
TUMOR BIOL .
2016 Apr;37(4):5355-63.
(IF 3.65)
449. Liu X, Zhou L, Chen X, Liu T, Pan G, Cui W, Li M, Luo ZP, Pei M, Yang H, Gong Y, He F .
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Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells.
MAT SCI ENG C-MATER.
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(IF 5.88)
450. Cui R, Guan Y, Sun C, Chen L, Bao Y, Li G, Qiu B, Meng X, Pang C, Wang Y .
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A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targetingFOXP1 in human glioma.
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451. Chen W, Su H, Xu Y, Bao T, Zheng X.
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Protective effect of wild raspberry (Rubus hirsutus Thunb) extract against acrylamide-induced oxidativedamage is potentiated after simulated gastrointestinal digestion.
Food Chem.
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452. Su S, Liu J, He K, Zhang M, Feng C, Peng F, Li B, Xia X .
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Overexpression of the long noncoding RNA TUG1 protects against cold-induced injury of mouse livers byinhibitingapoptosis and inflammation.
FEBS J.
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453. Li Z, Wang B, Tang L, Chen S, Li J .
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Quinazoline derivative compound (11d)as a novel angiogenesis inhibitor inhibiting VEGFR2
Iran J Basic Med Sci.
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454. Jin F, Qiao C, Luan N, Li H .
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Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, andinduces apoptosis.
Int J Mol Med.
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455. Wang W, Song XW, Bu XM, Zhang N, Zhao CH .
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PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
CELL ONCOL.
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(IF 5.304)
456. Han Y, Liu X, Shi B, Xiao R, Gou M, Wang H, Li Q.
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Identification and characterisation of the immune response properties of Lampetra japonica BLNK.
SCI REP-UK.
2016 Apr 29;6:25308.
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457. Cui YY, Yan L, Zhou J, Zhao S, Zheng YB, Sun BH, Lv HT, Rong FN, Chang XT .
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The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion.
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2016 Apr;37(4):5375-83.
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458. Zhang G, Xia F, Zhang Y, Zhang X, Cao Y, Wang L, Liu X, Zhao G, Shi M .
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Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation.
Mol Neurobiol.
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(IF 4.5)
459. Liu Y, Wang J, Ni T, Wang L, Wang Y, Sun X .
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CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial
ONCOTARGET.
2016 May 3;7(18):25328-39.
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460. Fu Y, Lin T, Liang A, Hu F.
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Effects of recombinant baculovirus AcMNPV-BmK IT on the formation of early cables
Cytotechnology.
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461. Zhang M, Li L, Xie W, Wu JF, Yao F, Tan YL, Xia XD, Liu XY, Liu D, Lan G, Zeng MY, Gong D, Cheng HP, Huang C, Zhao ZW, Zheng XL, Tang CK .
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Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation.
Atherosclerosis.
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462. Wang R, Ma L, Weng D, Yao J, Liu X, Jin F.
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Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway.
Oncol Rep.
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463. Xu T, Qin L, Zhu Z, Wang X, Liu Y, Fan Y, Zhong S, Wang X, Zhang X, Xia L, Zhang X, Xu C, Shen Z.
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MicroRNA-31 functions as a tumor suppressor and increases sensitivity to mitomycin-C in urothelialbladder cancer by targeting integrin α5.
ONCOTARGET.
2016 May 10;7(19):27445-57.
(IF 5.168)
464. Xie W, Wang M, Chen C, Zhang X, Melzig MF .
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Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury.
Life Sci.
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465. Zhang LY, Xue HG, Chen JY, Chai W, Ni M .
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Genistein induces adipogenic differentiation in human bone marrow mesenchymal stem cells andsuppresses their osteogenic potential by upregulating PPARγ.
Exp Ther Med.
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466. Hong Y, Shen C, Yin Q, Sun M, Ma Y, Liu X .
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Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced
Neurochem Res.
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467. Xie T, Ren HY, Lin HQ, Mao JP, Zhu T, Wang SD, Ye ZM .
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Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression oftumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway.
Int J Oncol.
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468. Wang Y, Huang HY, Yang L, Zhang Z, Ji H .
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Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer andovercomes drug resistance.
SCI REP-UK.
2016 May 6;6:25468.
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469. Wu J, Zhang M, Li H, Sun X, Hao S, Ji M, Yang J, Li K .
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BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced
Behav Brain Res.
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470. Yu H, Guan Q, Guo L, Zhang H, Pang X, Cheng Y, Zhang X, Sun Y.
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Gypenosides alleviate myocardial ischemia-reperfusion injury via attenuation of oxidative stress andpreservation of mitochondrial function in rat heart.
CELL STRESS CHAPERON.
2016 May;21(3):429-37.
(IF 2.892)
471. Guo W, Yu D, Wang X, Luo C, Chen Y, Lei W, Wang C, Ge Y, Xue W, Tian Q, Gao X, Yao W .
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Anti-inflammatory effects of interleukin-23 receptor cytokine-binding homology region rebalance T celldistribution in rodent collagen-induced arthritis.
ONCOTARGET.
2016 May 31;7(22):31800-13.
(IF 5.168)
472. Wu-jiao Bai, Peng-jing Jin, Mei-qian Kuang, Quan-wei Wei, Fang-xiong Shi, John S. Davis, Da-gan Mao.
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Temporal regulation of extracellular signal-regulated kinase 1/2 phosphorylation, heat shock protein 70 and activating transcription factor 3 during prostaglandin F-induced luteal regression in pseudopregnant rats following heat stress.
REPROD FERT DEVELOP.
12 May 2016, 29(6) 1184-1193.
(IF 1.718)
473. Zhang W, Ni P, Mou C, Zhang Y, Guo H, , Zhao T, Loh YH, Chen L.
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Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.
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477. Li Y, Shi S, Gao J, Han S, Wu X, Jia Y, Su L, Shi J, Hu D.
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Cryptotanshinone downregulates the profibrotic activities of hypertrophic scar fibroblasts and accelerateswound healing: A potential therapy for the reduction of skin scarring.
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481. Hua K, Jin J, Zhao J, Song J, Song H, Li D, Maskey N, Zhao B, Wu C, Xu H, Fang L.
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484. Yang Yang, Yanyan Sun, Laiyang Cheng, Anna Li, Yanjun Shen, Ligang Jiang, Xiaohui Deng, Lan Chao.
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568. Song G, Shen Y, Ruan Z, Li X, Chen Y, Yuan W, Ding X, Zhu L, Qian L.
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LncRNA-uc.167 influences cell proliferation, apoptosis and differentiation of P19 cells by regulating Mef2c.
Gene.
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Downregulation of cell division cycle 25 homolog C reduces the radiosensitivity and proliferation activity ofesophageal squamous cell carcinoma.
Gene.
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Necrostatin-1 protects against oleic acid-induced acute respiratory distress syndrome in rats.
BIOCHEM BIOPH RES CO.
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571. Yuan P, Cao W, Zang Q, Li G, Guo X, Fan J .
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572. Zhang L, Li Z, Shi T, La X, Li H, Li Z .
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Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic fortargeting cancer cells.
BMC Biotechnol.
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J Physiol Biochem.
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Hepatocyte growth factor-induced differentiation of bone mesenchymal stem cells toward hepatocyte-likecells occurs through nuclear factor-kappa B signaling in vitro.
Cell Biol Int.
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The Riemerella anatipestifer AS87_01735 Gene Encodes Nicotinamidase PncA, an Important VirulenceFactor.
APPL ENVIRON MICROB.
2016 Sep 16;82(19):5815-23.
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576. Dai C, Li B, Zhou Y, Li D, Zhang S, Li H, Xiao X, Tang S.
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Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation ofNrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells.
Food Chem Toxicol.
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cTnI Exacerbates Myocardial Ischemia/Reperfusion Injury by Inducing Adhesion of Monocytes to VECs via TLR4/NF-κB-dependent Pathway.
CLIN SCI.
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578. Dai C, Tang S, Velkov T, Xiao X.
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Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Mol Neurobiol.
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INT J NANOMED.
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580. Dai C, Tang S, Velkov T, Xiao X .
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Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species,Mitochondrial Dysfunction, and Autophagy.
Mol Neurobiol.
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581. Li J, An G, Zhang M, Ma Q .
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Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells.
BIOCHEM BIOPH RES CO.
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582. Liu YW, Zhang L, Li Y, Cheng YQ, Zhu X, Zhang F, Yin XX.
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Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitroand in vivo evidences.
Mol Neurobiol.
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583. Fan YL, Li HC, Zhao W, Peng HH, Huang F, Jiang WH, Xu SY.
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Curcumin Attenuated Bupivacaine-Induced Neurotoxicity in SH-SY5Y Cells Via Activation of the AktSignaling Pathway.
Neurochem Res.
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584. Li X, Wu Y, Liu A, Tang X.
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MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promotermethylation and regulates tamoxifen sensitivity by targeting HMGB3.
BIOCHEM BIOPH RES CO.
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585. Tan Z, Luo M, Yang J, Cheng Y, Huang J, Lu C, Song D, Ye M, Dai M, Gonzalez FJ, Liu A, Guo B.
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Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate:
J Pharm Pharmacol.
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586. Xu L, Wang YR, Li PC, Feng B.
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Advanced glycation end products increase lipids accumulation in macrophages through upregulation ofreceptor of advanced glycation end products: increasing uptake, esterification and decreasing efflux of cholesterol.
Lipids Health Dis.
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587. Zhao W, Li A, Feng X, Hou T, Liu K, Liu B, Zhang N .
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Metformin and resveratrol ameliorate muscle insulin resistance through Preventing
Cell Signal.
2016 Sep;28(9):1401-11.
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588. Wang Q, Zhou JL, Wang H, Ju Q, Ding Z, Zhou XL, Ge X, Shi QM, Pan C, Zhang JP, Zhang MR, Yu HM, Xu LC.
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Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-inducedandrogen receptor activation.
Chemosphere.
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589. Chai J, Luo L, Hou F, Fan X, Yu J, Ma W, Tang W, Yang X, Zhu J, Kang W, Yan J, Liang H .
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Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages.
PLoS One.
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590. Chen Y, Cao J, Zhang X.
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The Role of Cytokine PF4 in the Antiviral Immune Response of Shrimp.
PLoS One.
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591. Wang Z, Zhang H, Sun X, Ren L .
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The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signalingand activation of the Nrf2/HO-1 pathway.
Mol Med Rep.
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592. Liu L, Zhao X, Zou H, Bai R, Yang K, Tian Z .
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Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent
Front Physiol.
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593. Chen Z, Han S, Huang W, Wu J, Liu Y, Cai S, He Y, Wu S, Song W .
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MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang1.
BIOCHEM BIOPH RES CO.
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594. Lu H, Zhang L, Gu LL, Hou BY, Du GH .
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Oxymatrine Induces Liver Injury through JNK Signalling Pathway Mediated by TNF-α In Vivo.
BASIC CLIN PHARMACOL.
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Fucoidan inhibits angiogenesis induced by multiple myeloma cells.
Oncol Rep.
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596. Xiao F, Zhang P, Chen AH, Wang CY, Zou W, Gu HF, Tang XQ .
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Hydrogen sulfide inhibits MPP+-induced aldehyde stress and endoplasmic reticulum stress in PC12 cells:involving upregulation of BDNF.
Exp Cell Res.
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Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53Signaling Pathway Activation.
Int J Biol Sci.
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598. Zhang X, Wang L, Wang Y, Shi S, Zhu H, Xiao F, Yang J, Yang A, Hao X .
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Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controllingBCL11A/MDM2 expression.
Oncol Rep.
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Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cellsand db/db mice.
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Heavy chain (LvH) and light chain (LvL) of lipovitellin (Lv) of zebrafish can both bind
Dev Comp Immunol.
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601. Lu C, Yang L, Chen H, Shan Z.
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Upregulated long non-coding RNA BC032469 enhances carcinogenesis and metastasis of esophageal squamous cell carcinoma through regulating hTERT expression.
TUMOR BIOL .
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602. Hua K, Jin J, Zhang H, Zhao B, Wu C, Xu H, Fang L.
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MicroRNA-7 inhibits proliferation, migration and invasion of thyroid papillary cancer cells via targetingCKS2.
Int J Oncol.
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Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation ofNrf2/HO-1 Defense Pathway.
Cardiovasc Toxicol.
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Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actinRelated Cytoskeletal Reorganization.
Int J Biol Sci.
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605. Teng H, Wang P, Xue Y, Liu X, Ma J, Cai H, Xi Z, Li Z, Liu Y.
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Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells.
Mol Ther.
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HBx mutations promote hepatoma cell migration through the Wnt/β-catenin
Cancer Sci.
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HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be
Am J Transl Res.
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Apoptosis repressor with caspase recruitment domain enhances survival and promotes osteogenic differentiation of human osteoblast cells under Zoledronate treatment.
Mol Med Rep.
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Toxicology.
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Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances TamoxifenResistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway.
MED SCI MONITOR.
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612. Sun X, Zuo H, Liu C, Yang Y.
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Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating thekelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.
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613. Wang XD, Li F, Ma DB, Deng X, Zhang H, Gao J, Hao L, Liu DD, Wang J.
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Biomed Pharmacother.
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Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral
Neuroscience.
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Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivoand in vitro study.
J CANCER RES CLIN.
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Over-expression of heat shock protein 70 protects mice against lung ischemia/reperfusion injury through SIRT1/AMPK/eNOS pathway.
Am J Transl Res.
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Eur J Pharm Sci.
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620. Chen D, Xia D, , Pan Z, Xu D, Zhou Y, Wu Y, Cai N, Tang Q, Wang C, Yan M, Zhang JJ, Zhou K, Wang Q, Feng Y, Wang X, Xu H, Zhang X, , Tian N.
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Cell Death Dis.
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Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like CellsThrough the BMP-2/Smad/RUNX2 Signaling Pathway.
Biol Trace Elem Res.
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622. Li Y, Pan K, Chen L, Ning JL, Li X, Yang T, Terrando N, Gu J, Tao G .
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Cell Death Dis.
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624. Li J, Chen Z, Zhou X, Shi S, Qi H, Baker PN, Zhang H .
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Imbalance between proliferation and apoptosis-related impaired GPR30 expression is involved inpreeclampsia.
Cell Tissue Res.
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625. Chen P, He D, Zhang Y, Yang S, Chen L, Wang S, Zou H, Liao Z, Zhang X, Wu M .
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Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependentcytoprotection and ameliorate stress insult during aging.
Food Funct.
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626. Ye L, Lin ST, Mi YS, Liu Y, Ma Y, Sun HM, Peng ZH, Fan JW .
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Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potentialtherapeutic target.
TUMOR BIOL .
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627. Zheng L, Zhai Y, Li N, Ma F, Zhu H, Du X, Li G, Hua J.
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The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation.
SCI REP-UK.
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628. Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y, Wang Y.
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Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 inhuman osteosarcoma.
TUMOR BIOL .
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629. Kuang X, Wei C, Zhang T, Yang Z, Chi J, Wang L.
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miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes.
Int J Oncol.
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630. Wang YJ, Liu JZ, Lv P, Dang Y, Gao JY, Wang Y .
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Long non-coding RNA CCAT2 promotes gastric cancer proliferation and invasion by regulating the E-cadherin and LATS2.
Am J Cancer Res.
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631. Qiu G, Wang P, Li G, Shi Z, Weir MD, Sun J, Song Y, Wang J, Xu HH, Zhao L.
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Minipig-BMSCs Combined with a Self-Setting Calcium Phosphate Paste for Bone Tissue Engineering.
Mol Biotechnol.
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Osteogenic activity and antibacterial effect of zinc oxide/carboxylated graphene oxide nanocomposites:Preparation and in vitro evaluation.
COLLOID SURFACE B.
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634. Chen T, Ma Z, Zhu L, Jiang W, Wei T, Zhou R, Luo F, Zhang K, Fu Q, Ma C, Yan T.
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Suppressing Receptor-Interacting Protein 140:a New Sight for Salidroside to Treat Cerebral Ischemia.
Mol Neurobiol.
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635. Yang Y, Ren J, Tong Y, Hu X, Lv Q, Tong N.
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Lipids.
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636. Li Y, Shi X, Li J, Zhang M, Yu B .
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637. Yang X, Huo H, Xiu C, Song M, Han Y, Li Y, Zhu Y .
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Food Chem Toxicol.
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639. Hu Y, Niu X, Wang G, Huang J, Liu M, Peng B.
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Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelialdysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model.
Andrology.
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640. Lianmei Zhao, Taotao Han, Yanshuang Li, Jiazeng Sun, Shang Zhang, Yanxin Liu, Baoen Shan, Dexian Zheng, Juan Shi.
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Sevoflurane protects against hepatic ischemia/reperfusion injury by modulating microRNA-200c regulationin mice.
Biomed Pharmacother.
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FREE RADICAL BIO MED.
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652. Jiang X, Yang Y, Zhou J, Zhu L, Gu Y, Zhang X, Li X, Fang W .
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Glucose-Regulated Protein 78-Induced Myeloid Antigen-Presenting Cells Maintained Tolerogenic Signatureupon LPS Stimulation.
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ONCOTARGETS THER.
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755. Lingyan Yang, Wen-Cheng Wang, Shih-Chun Candice Lung, Zhelin Sun, Chongjun Chen, Jen-Kun Chen, Qiang Zou, Yu-Hsin Lin, Chia-Hua Lin.
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Science of The Total Environment.
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Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.
Metab Brain Dis.
2017 Apr;32(2):385-393.
(IF 2.726)
918. Zhu WJ, Yang SD, Qu CX, Zhu QL, Chen WL, Li F, Yuan ZQ, Liu Y, You BG, Zhang XN.
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Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent co-delivery of paclitaxel and siRNA to breast tumor.
INT J NANOMED.
2017 Apr 26;12:3375-3393.
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919. Zhang M, Fang X, Wang GS, Ma Y, Jin L, Li XM, Li XP.
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Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus.
Inflammopharmacology.
2017 Apr;25(2):203-210.
(IF 3.238)
920. Liu X, Wang Y, Cao Z, Dou C, Bai Y, Liu C, Dong S, Fei J.
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Staphylococcal lipoteichoic acid promotes osteogenic differentiation of mouse mesenchymal stem cells by increasing autophagic activity.
BIOCHEM BIOPH RES CO.
2017 Apr 1;485(2):421-426.
(IF 2.985)
921. Guangyuan Zhao, Cheng Fu, Lu Wang, Lan Zhu, Yutao Yan, Ying Xiang, Fang Zheng, Feili Gong, Song Chen, Gang Chen.
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Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury.
Scientific Reports.
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922. Li MS, Xin M, Guo CL, Lin GM, Li J, Wu XG.
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Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice.
INT J OPHTHALMOL-CH.
2017 Apr 18;10(4):515-523.
(IF 1.166)
923. Liu S, Liang B, Jia H, Jiao Y, Pang Z, Huang Y.
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Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells.
FEBS Open Bio.
2017 Apr 27;7(6):798-810.
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924. Qu XY, Tao LN, Zhang SX, Sun JM, Niu JQ, Ding YH, Song YQ.
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The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice.
ENVIRON TOXICOL CHEM.
2017 Apr;51:16-22.
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925. Li C, Zheng L, Xin Y, Tan Z, Zhang Y, Meng X, Wang Z, Xi T.
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The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.
FEBS Lett.
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926. Wang CP, Shi YW, Tang M, Zhang XC, Gu Y, Liang XM, Wang ZW, Ding F.
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Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats.
Mol Neurobiol.
2017 Apr;54(3):2126-2142.
(IF 4.5)
927. Chen J, Huang C, Wang J, Zhou H, Lu Y, Lou L, Zheng J, Tian L, Wang X, Cao Z, Zeng Y.
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Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats.
PLoS One.
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928. Yao Y, Wang Y, Zhang Y, Liu C.
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Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways.
Lipids Health Dis.
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929. Xie GL, Zhu L, Zhang YM, Zhang QN, Yu Q.
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Change in iron metabolism in rats after renal ischemia/reperfusion injury.
PLoS One.
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930. Li W, Zheng M, Wu S, Gao S, Yang M, Li Z, Min Q, Sun W, Chen L, Xiang G, Li H.
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Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
J EXP CLIN CANC RES.
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931. Tian Y, Song Y, Bai W, Ma X, Ren Z.
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CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells.
Oncol Lett.
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932. Jing YY, Li D, Wu F, Gong LL, Li R.
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GDF11 does not improve the palmitate induced insulin resistance in C2C12.
EUR REV MED PHARMACO.
2017 Apr;21(8):1795-1802.
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933. Dai F, Xuan Y, Jin JJ, Yu S, Long ZW, Cai H, Liu XW, Zhou Y, Wang YN, Chen Z, Huang H.
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CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis.
ONCOTARGET.
2017 Apr 25;8(17):28736-28749.
(IF 5.168)
934. Zou W, Zhou H, Hu J, Zhang L, Tang Q, Wen X, Xiao Z, Wang W.
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Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-κB pathway.
J Ethnopharmacol.
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935. Li LS, Lu YL, Nie J, Xu YY, Zhang W, Yang WJ, Gong QH, Lu YF, Lu Y, Shi JS.
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Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by Aβ25-35 in hippocampus neurons in vitro.
CNS Neurosci Ther.
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936. Zhang L, Gan X, He Y, Zhu Z, Zhu J, Yu H.
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Drp1-dependent mitochondrial fission mediates osteogenic dysfunction in inflammation through elevated production of reactive oxygen species.
PLoS One.
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937. Zhu TT, Zhang WF, Luo P, Qian ZX, Li F, Zhang Z, Hu CP.
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LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats.
Life Sci.
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938. Xiuyan Wang, Liyu Zheng, Jinming Wu, Binbin Tang, Mengqin Zhang, Debin Zhu, Xianfan Lin.
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Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease.
Molecular Medicine Reports.
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939. Mengqian Li, Yefeng Yuan, Bo Hu, Lei Wu.
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Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer’s Disease.
Journal of Molecular Neuroscience.
April 2017, Volume 61, Issue 4, pp 489–497.
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940. Wang Y, Wang D, Xie G, Yin Y, Zhao E, Tao K, Li R.
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MicroRNA-152 regulates immune response via targeting B7-H1 in gastric carcinoma.
ONCOTARGET.
2017 Apr 25;8(17):28125-28134.
(IF 5.168)
941. Wang Z, Yuan J, Li L, Yang Y, Xu X, Wang Y.
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Long non-coding RNA XIST exerts oncogenic functions in human glioma by targeting miR-137.
Am J Transl Res.
2017 Apr 15;9(4):1845-1855. eCollection 2017.
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942. Yin K, Zhu R, Wang S, Zhao RC.
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Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Stem Cells Dev.
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943. Qi-sang Guo, Yu Song, Ke-qin Hua, Shu-jun Gao.
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Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines.
Scientific Reports.
18 May 2017.
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944. Cheng L, Liu J, Liu Q, Liu Y, Fan L, Wang F, Yu H, Li Y, Bu L, Li X, Wei W, Wang H, Sun G.
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Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages.
Int J Biol Sci.
2017 May 16;13(6):723-734.
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945. Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW.
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Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
BIOCHEM BIOPH RES CO.
2017 May 20;487(1):181-188.
(IF 2.985)
946. Hong Ren, Juan Han, Zhifang Li, Zhiyong Xiong.
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Stem Cell Factor/Kit Signal Insufficiency Contributes to Hypoxia-Induced Intestinal Motility Dysfunctions in Neonatal Mice.
Digestive Diseases and Sciences.
May 2017, Volume 62, Issue 5, pp 1193–1203.
(IF 2.937)
947. Li J, Guo Y, Duan L, Hu X, Zhang X, Hu J, Huang L, He R, Hu Z, Luo W, Tan T, Huang R, Liao D, Zhu YS, Luo DX.
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AKR1B10 promotes breast cancer cell migration and invasion via activation of ERK signaling.
ONCOTARGET.
2017 May 16;8(20):33694-33703.
(IF 5.168)
948. Li L, Wang L, Song R, Chen G, Liu Y.
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Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2.
Int J Oncol.
2017 May;50(5):1832-1838.
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949. Pei Wu, Yuchen Li, Shiyi Zhu, Chunlei Wang, Jiaxing Dai, Guang Zhang, Bingjie Zheng, Shancai Xu, Ligang Wang, Tongyu Zhang, PeiQuan Zhou, John H.Zhang, Huaizhang Shi.
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Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress.
Neurochemical Research.
May 2017, Volume 42, Issue 5, pp 1449–1458.
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950. Li X, Yang B, Wang L, Chen L, Luo X, Liu L.
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SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes.
Oncol Rep.
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951. Liu Bin, Jia Kaiqiao, Yang Yu, Hao Siyuan, Lu Caijie, Xu Fengming, Feng Dehui, Zhu Runzhi.
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Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.
Protein and Peptide Letters.
May 2017, pp. 406-412(7).
(IF 1.168)
952. Jun Lou, Yongli Wang, Zhimin Zhang, Weiqiang Qiu.
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Activation of MMPs in Macrophages by Mycobacterium tuberculosis via the miR‐223‐BMAL1 Signaling Pathway.
Journal of Cellular Biochemistry.
19 May 2017.
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953. Yanjun Sun, Chuan Jiang, Jun Jiang, Lisheng Qiu.
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Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway.
Wiley Online Library.
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954. Zhan A, Lei B, Wu H, Wen Y, Zheng L, Wang S, Wan X, Wei Z.
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GGNBP2 Suppresses the Proliferation, Invasion, and Migration of Human Glioma Cells.
Oncol Res.
2017 May 24;25(5):831-842.
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955. Hongming Lv, Qinmei Liu, Junfeng Zhou, Guangyun Tan, Xuming Deng, Xinxin Ci.
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Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.
Free Radical Biology and Medicine.
Volume 106, May 2017, Pages 38-52.
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956. Yong-qiang Ren, Hui-jun Wang, Yong-qing Zhang, Yan-bing Liu.
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WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206.
Cancer Chemotherapy and Pharmacology.
May 2017, Volume 79, Issue 5, pp 1003–1011.
(IF 3.008)
957. Xin Chen, Hai-Wen Ding, Hai-Di Li, Hui-Min Huang, Xiao-Feng Li, Yang Yang, Yi-Long Zhang, Xue-Yin Pan, Cheng Huang, Xiao-Ming Meng, Jun Li.
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Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl4-induced acute liver injury and LPS-treated RAW264.7 cells.
Toxicology Letters.
Volume 274, 15 May 2017, Pages 51-63.
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958. Liu Bin, Zhang Miaomiao, Liu Shuna, Ying Jie, Zhang Jingjing, Kurihara Hiroshi, Zheng Weiqiang, He Rong-Rong, Zhu Runzhi.
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Diosmetin, a Potential p53 Activator, Performs Anticancer Effect by Regulating Cell Cycling and Cell Proliferation in HepG2 Cells.
Protein and Peptide Letters.
Volume 24, Number 5, May 2017, pp. 413-418(6).
(IF 1.168)
959. Zhang JF, Zhang L, Shi LL, Zhao ZH, Xu H, Liang F, Li HB, Zhao Y, Xu X, Yang K, Tian YF.
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Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3β pathway in PC12 cells.
Biomed Pharmacother.
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960. Ye M, He Y, Lin H, Yang S, Zhou Y, Zhou L, Zhong J, Lu G, Zheng J, Xue ZX, Cai ZZ.
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High expression of atonal homolog 8 predicts a poor clinical outcome in patients with colorectal cancer and contributes to tumor progression.
Oncol Rep.
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961. Guo Dong, Shusen Yang, Xuefei Cao, Nannan Yu, Jiangbo Yu, Xiufen Qu.
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Low shear stress-induced autophagy alleviates cell apoptosis in HUVECs.
Molecular Medicine Reports.
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962. Ma K, Ma P, Lu H, Liu S, Cao Q.
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Fentanyl Suppresses the Survival of CD4+ T Cells Isolated from Human Umbilical Cord Blood through Inhibition of IKKs-mediated NF-κB Activation.
Scand J Immunol.
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963. Linxi Yu, Xiaoxin Liu, Zihang Yuan, Xiaojiaoyang Li, Hang Yang, Ziqiao Yuan, Lixin Sun, Luyong Zhang, Zhengzhou Jiang.
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SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model.
ORIGINAL RESEARCH ARTICLE.
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964. Hui Y, Lu M, Han Y, Zhou H, Liu W, Li L, Jin R.
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Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats.
Acta Histochem.
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965. Zuo Z, Qi F, Yang J, Wang X, Wu Y, Wen Y, Yuan Q, Zou J, Guo K, Yao ZB.
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Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain.
Neurobiol Dis.
2017 May;101:27-39.
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966. Zhang L, Xiao X, An H, Wang J, Ma Y, Qian YH.
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Inhibition of CCR7 promotes NF-κB-dependent apoptosis and suppresses epithelial-mesenchymal transition in non-small cell lung cancer.
Oncol Rep.
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967. Chen X, Xu H, Wu N, Liu X, Qiao G, Su S, Tian Y, Yuan R, Li C, Liu X, Lin X.
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Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells.
ONCOTARGET.
2017 May 2;8(18):30305-30316.
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968. Meng Z, Guo L, Li Q.
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Peptide-Coated Semiconductor Polymer Dots for Stem Cells Labeling and Tracking.
Chemistry.
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969. Mo D, Yang D, Xiao X, Sun R, Huang L, Xu J.
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MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin.
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970. Chen Y, Zhou CF, Xiao F, Huang HL, Zhang P, Gu HF, Tang XQ.
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Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide.
CLIN EXP PHARMACOL P .
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971. Deng Z, Jin J, Wang Z, Wang Y, Gao Q, Zhao J.
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The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening.
INT J NANOMED.
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972. Gong ZY, Yuan ZQ, Dong ZW, Peng YZ.
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Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation.
Am J Transl Res.
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973. Zhou J, Wang J, Li W, Wang C, Wu L, Zhang J.
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Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury.
Mol Med Rep.
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974. Zhao H, Liu F, Jia R, Chang H, Li H, Miao M, Wang H, Yang Z.
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MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia.
Iran J Basic Med Sci.
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Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway.
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976. Su ZQ, Liu YH, Guo HZ, Sun CY, Xie JH, Li YC, Chen JN, Lai XP, Su ZR, Chen HM.
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Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin.
Int Immunopharmacol.
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977. CHUNHUA LIN, JIAHUI WANG, YANWEI WANG, PENG ZHU, XIN LIU, NING LI, JUAN LIU, LUXIN YU, WENTING WANG.
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GRP78 Participates in PCA3-regulated Prostate Cancer Progression.
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COLLOID SURFACE B.
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979. Ye Q, Chen C, Si E, Cai Y, Wang J, Huang W, Li D, Wang Y, Chen X.
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Mitochondrial Effects of PGC-1alpha Silencing in MPP+ Treated Human SH-SY5Y Neuroblastoma Cells.
Front Mol Neurosci.
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980. Chen L, Huang J, Yang L, Zeng XA, Zhang Y, Wang X, Chen M, Li X, Zhang Y, Zhang M.
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Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism.
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Dcf1 regulates neuropeptide expression and maintains energy balance.
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982. Lijun Tao, Fengyan Cao, Gonghao Xu, Haifeng Xie, Mian Zhang, Chaofeng Zhang.
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Mogroside IIIE Attenuates LPS‐Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF‐κB Axis via AMPK Activation.
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983. Kun Zhuang, Lingxia Zhang, Xin Zhang, Hailing Tang, Jun Zhang, Yuan Yan, Kun Han, Hanqing Guo.
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Gastrin induces multidrug resistance via the degradation of p27Kip1 in the gastric carcinoma cell line SGC7901.
International Journal of Oncology.
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984. Zhou Q, Zhu S, Guo Y, Lian L, Hu Q, Liu X, Xu F, Zhang N, Kang H.
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Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Mol Neurobiol.
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985. Zhang X, Liu S, Zhang G, Zhong M, Liu T, Wei M, Wu D, Huang X, Cheng Y, Wu Q, Hu S.
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Bariatric Surgery Ameliorates Diabetic Cardiac Dysfunction by Inhibiting ER Stress in a Diabetic Rat Model.
Obes Surg.
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986. Yiting Lou, Chenggui Wang, Wenhao Zheng, Qian Tang, Yu Chen, Xiaolei Zhang, Xiaoshan Guo, Jianshun Wang.
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Salvianolic acid B inhibits IL-1β-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model.
International Immunopharmacology.
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987. Qin X, Yu S, Zhou L, Shi M, Hu Y, Xu X, Shen B, Liu S, Yan D, Feng J.
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Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner.
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988. Jianshu Gao, Xiaoqiang Liu, Bingjian Wang, Haiyan Xu, Qiang Xia, Tianfei Lu, Fang Wang.
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Farnesoid X receptor deletion improves cardiac function, structure and remodeling following myocardial infarction in mice.
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Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line.
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990. Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F.
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Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
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991. Xin Wang, Peng Xiu, Fuhai Wang, Jingtao Zhong, Honglong Wei, Zongzhen Xu, Feng Liu, Jie Li.
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P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF/VEGFR2 signalling pathway.
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Antibacterial, osteogenic, and angiogenic activities of SrTiO3 nanotubes embedded with Ag2O nanoparticles.
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993. Xiang Y, Ye W, Huang C, Lou B, Zhang J, Yu D, Huang X, Chen B, Zhou M.
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Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway.
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Excess trehalose and glucose affects chitin metabolism in brown planthopper (Nilaparvata lugens).
Journal of Asia-Pacific Entomology.
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Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathway.
ONCOTARGET.
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TGF-β1 promotes human hepatic carcinoma HepG2 cells invasion by upregulating autophagy.
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GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney.
ONCOTARGET.
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Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection.
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MicroRNA-mediated inflammatory responses induced by Cryptococcus neoformans are dependent on the NF-κB pathway in human monocytes.
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ONCOTARGET.
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BASIC CLIN PHARMACOL.
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ONCOTARGET.
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ONCOTARGET.
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1093. Yang Y, Jin G, Liu H, Liu K, Zhao J, Chen X, Wang D, Bai R, Li X, Jang Y, Lu J, Xing Y, Dong Z.
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Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway.
ONCOTARGET.
2017 Aug 18;8(43):74673-74687.
(IF 5.168)
1094. Jiang W, Chen Y, Li B, Gao S.
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DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus.
Mol Biosyst.
2017 Aug 22;13(9):1863-1873.
(IF 3.336)
1095. Gao P, Qiao X, Sun H, Huang Y, Lin J, Li L, Wang X, Li C.
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Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner.
ONCOTARGET.
2017 Aug 3;8(48):83900-83912.
(IF 5.168)
1096. Quan Chen, Guanghua Luo, Xiaoying Zhang.
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MiR-148a modulates HLA-G expression and influences tumor apoptosis in esophageal squamous cell carcinoma.
Experimental and Therapeutic Medicine.
August 28, 2017.
(IF 1.448)
1097. Leiming Zhang, Maojing Zhu, Minmin Li, Yuan Du, Sijin Duan, Yanan Huang, Yongying Lu, Jianqiao Zhang, Tian Wang, Fenghua Fu.
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Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway.
ONCOTARGET.
2017 Aug 15; 8(33): 55384–55393.
(IF 5.168)
1098. Cai B, Xiao Y, Li Y, Zheng S.
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CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis.
Oncol Lett.
2017 Aug;14(2):1536-1542.
(IF 2.311)
1099. Wang X, Chen J, Wang H, Yu H, Wang C, You J, Wang P, Feng C, Xu G, Wu X, Zhao R, Zhang G.
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Memantine Can Reduce Ethanol-Induced Caspase-3 Activity and Apoptosis in H4 Cells by Decreasing Intracellular Calcium.
J Mol Neurosci.
2017 Aug;62(3-4):402-411.
(IF 2.678)
1100. Ling F, Tang Y, Li M, Li QS, Li X, Yang L, Zhao W, Jin CC, Zeng Z, Liu C, Wu CF, Chen WW, Lin X, Wang YL, Threadgill MD.
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Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300.
ONCOTARGET.
2017 Aug 18;8(42):72773-72787.
(IF 5.168)
1101. Ding Y, Gu Z, Wang Y, Wang S, Chen H, Zhang H, Chen W, Chen YQ.
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Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.
Food Funct.
2017 Aug 1;8(8):2847-2856.
(IF 4.171)
1102. Zhang GM, Deng MT, Lei ZH, Wan YJ, Nie HT, Wang ZY, Fan YX, Wang F, Zhang YL.
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Effects of NRF1 on steroidogenesis and apoptosis in goat luteinized granulosa cells.
Reproduction.
2017 Aug;154(2):111-122.
(IF 3.206)
1103. Shen CJ, Cheng YM, Wang CL.
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LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells.
J Drug Target.
2017 Aug;25(7):637-644.
(IF 3.38)
1104. Chen B, Na F, Yang H, Li R, Li M, Sun X, Hu B, Huang G, Lan J, Xu H, Tong R, Mo X, Xue J, Lu Y.
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Ethyl pyruvate alleviates radiation-induced lung injury in mice.
Biomed Pharmacother.
2017 Aug;92:468-478.
(IF 4.545)
1105. Lin J, Wang C, Zhang L, Wang T, Zhang J, Liang W, Li C, Qian G, Ouyang Y, Guo K, Zhang Y.
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Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Front Microbiol.
2017 Aug 8;8:1468.
(IF 4.235)
1106. Sun L, Yuan Q, Xu T, Yao L, Feng J, Ma J, Wang L, Lu C, Wang D.
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Pioglitazone Improves Mitochondrial Function in the Remnant Kidney and Protects against Renal Fibrosis in 5/6 Nephrectomized Rats.
Front Pharmacol.
2017 Aug 15;8:545.
(IF 4.225)
1107. Shen Y, Cao R, Liu W, Zhou Y, Wu Y, Tan J, Jin M, Zhong J, Zhang Q, Liu J, Zu X.
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Negative feedback loop between ZBTB7A and TGF-β in breast cancer.
Oncol Lett.
2017 Aug;14(2):1403-1410.
(IF 2.311)
1108. Cai M, Guo Y, Wang S, Wei H, Sun S, Zhao G, Dong H.
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Tanshinone IIA Elicits Neuroprotective Effect Through Activating the Nuclear Factor Erythroid 2-Related Factor-Dependent Antioxidant Response.
REJUV RES.
2017 Aug;20(4):286-297.
(IF 3.811)
1109. Wang Y, Yin X, Zhao L, Li S, Duan J, Kuang R, Duan J.
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MicroRNA-200b inhibits pituitary tumor cell proliferation and invasion by targeting PKCα.
Exp Ther Med.
2017 Aug;14(2):1706-1714.
(IF 1.785)
1110. Xu D, Liu Z, Wang S, Peng Y, Sun X.
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Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation.
BIOCHEM BIOPH RES CO.
2017 Aug 26;490(3):670-675.
(IF 2.985)
1111. Liu C, Wang Y, Li BS, Yang Q, Tang JM, Min J, Hong SS, Guo WJ, Hong L.
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Role of transforming growth factor β-1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target.
Int J Mol Med.
2017 Aug;40(2):347-356.
(IF 3.098)
1112. Liu S, Fei W, Shi Q, Li Q, Kuang Y, Wang C, He C, Hu X.
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CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response.
Cell Death Dis.
2017 Aug 24;8(8):e3009.
(IF 6.304)
1113. Wang M, Zhang J, Huang Y, Ji S, Shao G, Feng S, Chen D, Zhao K, Wang Z, Wu A.
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Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells.
MED SCI MONITOR.
2017 Aug 12;23:3904-3912.
(IF 1.918)
1114. Wang H, Jiang Z, Zhang J, Xie Z, Wang Y, Yang G.
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Enhanced osteogenic differentiation of rat bone marrow mesenchymal stem cells on titanium substrates by inhibiting Notch3.
Arch Oral Biol.
2017 Aug;80:34-40
(IF 1.931)
1115. Hong S, Hong L, Li B, Wu D, Liu C, Min J, Guo W, Hu M, Tang J, Li Y.
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The role of GPX1 in the pathogenesis of female pelvic organ prolapse.
PLoS One.
2017 Aug 7;12(8):e0181896.
(IF 2.74)
1116. Yicheng Liang, Hetan Wang, Yuanyuan Sun, Sheng Chen, Haoyou Wang, Rong Huang, Xinyi Zhao, Weineng Fu, Chunlu Yang.
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miR-198-induced upregulation of Livin may be associated with the prognosis and contribute to the oncogenesis of lung adenocarcinoma.
Oncology Reports.
August 1, 2017.
(IF 3.041)
1117. Chi J, Meng L, Pan S, Lin H, Zhai X, Liu L, Zhou C, Jiang C, Guo H.
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Primary Culture of Rat Aortic Vascular Smooth Muscle Cells: A New Method.
MED SCI MONITOR.
2017 Aug 19;23:4014-4020.
(IF 1.918)
1118. Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, Xu J, Zhou J.
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JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Toxicol Lett.
2017 Aug 5;277:32-40.
(IF 3.569)
1119. Wang Q, Jiang Y, Guo R, Lv R, Liu T, Wei H, Ming H, Tian X.
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Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.
Biomed Pharmacother.
2017 Aug;92:451-458.
(IF 4.545)
1120. Luan W, Li R, Liu L, Ni X, Shi Y, Xia Y, Wang J, Lu F, Xu B.
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Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p.
ONCOTARGET.
2017 Aug 3;8(49):85401-85414.
(IF 5.168)
1121. Zheng SW, Wan WG, Miao HX, Tang R, Wang B, Huang QZ, Liu WL, Zheng JP, Chen CQ, Zhong HB, Li SF, Sun CH.
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Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).
MED SCI MONITOR.
2017 Aug 27;23:4132-4140.
(IF 1.918)
1122. Lv H, Liu Q, Wen Z, Feng H, Deng X, Ci X.
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Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis.
Redox Biol.
2017 Aug;12:311-324.
(IF 9.986)
1123. Zhang D, Li C, Song Y, Zhou J, Li Y, Li J, Bai C.
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Integrin αvβ5 inhibition protects against ischemia-reperfusion-induced lung injury in an autophagy-dependent manner.
AM J PHYSIOL-LUNG C.
2017 Aug 1;313(2):L384-L394.
(IF 4.406)
1124. Liang Y, Niu H, Ma L, Du D, Wen L, Xia Q, Huang W.
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Eriodictyol 7‑O‑β‑D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.
Mol Med Rep.
2017 Aug;16(2):1298-1306.
(IF 2.1)
1125. Sun HJ, Xu DY, Sun YX, Xue T, Zhang CX, Zhang ZX, Lin W, Li KX.
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CO-releasing molecules-2 attenuates ox-LDL-induced injury in HUVECs by ameliorating mitochondrial function and inhibiting Wnt/β-catenin pathway.
BIOCHEM BIOPH RES CO.
2017 Aug 26;490(3):629-635.
(IF 2.985)
1126. Yin W, Ouyang S, Luo Z, Zeng Q, Hu B, Xu L, Li Y, Xiao B, Yang H.
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Immature Exosomes Derived from MicroRNA-146a Overexpressing Dendritic Cells Act as Antigen-Specific Therapy for Myasthenia Gravis.
Inflammation.
2017 Aug;40(4):1460-1473.
(IF 3.212)
1127. Zhenhua Feng, Wenhao Zheng, Qian Tang, Liang Cheng, Hang Li, Wenfei Ni, Xiaoyun Pan.
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Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats.
Apoptosis.
August 2017, Volume 22, Issue 8, pp 1001–1012.
(IF 4.543)
1128. Cheng P, Wang T, Li W, Muhammad I, Wang H, Sun X, Yang Y, Li J, Xiao T, Zhang X.
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Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway.
Front Pharmacol.
2017 Aug 18;8:547.
(IF 4.225)
1129. Ai-Jun Xu, Li-Na Fu, Hua-Xing Wu, Xiao-Li Yao, Rui Meng.
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MicroRNA-744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor.
Molecular Medicine Reports.
August 4, 2017.
(IF 1.851)
1130. Shenglan Wang, Xuemei Wang, Zhanping Weng, Shuping Zhang, Hui Ning, Baolai Li.
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Expression and role of microRNA 18b and hypoxia inducible factor-1α in placental tissues of preeclampsia patients.
Experimental and Therapeutic Medicine.
August 30, 2017.
(IF 1.448)
1131. Yan J, Lai CH, Lung SC, Wang WC, Huang CC, Chen GW, Suo G, Choug CT, Lin CH.
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Carbon black aggregates cause endothelial dysfunction by activating ROCK.
J Hazard Mater.
2017 Sep 15;338:66-75.
(IF 9.038)
1132. Xiaojing Wang, Tianyuan Xu, Fengbin Gao, Hongchao He, Yu Zhu, Zhoujun Shen.
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Targeting of CCN2 suppresses tumor progression and improves chemo-sensitivity in urothelial bladder cancer.
ONCOTARGET.
2017 Sep 12; 8(39): 66316–66327.
(IF 5.168)
1133. Wenshuai Li, Huilu Zhang, Pei Min, Jie Zhu, Diannan Xu, Weiru Jiang, Yanyun Ma, Jigang Qiu, Weihong Xu, Jian Chen, Mingqing Zhang, Min Li, Dongqin Yang, Jianping Shi, Jun Zhang, Jie Liu.
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Downregulated miRNA-1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70.
Oncology Letters.
September 28, 2017.
(IF 1.871)
1134. Li X, Zhou X, Chen Y, Yu S, Chen X, Xia X, Shi X, Zhang Y, Fan D.
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Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.
J MATER SCI-MATER M.
2017 Sep 15;28(10):167.
(IF 2.489)
1135. Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, Jia Z, Zhang A.
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COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.
Am J Transl Res.
2017 Sep 15;9(9):3967-3976. eCollection 2017.
(IF 3.375)
1136. Yilian Pan, Xiaoyi Liu, Yong Huang.
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Small interfering RNA-mediated knockdown of Twist attenuates the aggressive phenotypes of human endometrial carcinoma Ishikawa cells.
Experimental and Therapeutic Medicine.
September 27, 2017.
(IF 1.448)
1137. Cuiting Qiu, Haijun Zheng, Huiren Tao, Wenjun Yu, Xiaoyu Jiang, Aiqin Li, Hui Jin, Anlin Lv, Huan Li.
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Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Molecular and Cellular Biochemistry.
September 2017, Volume 433, Issue 1–2, pp 149–159.
(IF 2.884)
1138. Lei Zhao, Hui Lin, Songfeng Chen, Sheng Chen, Min Cui, Deyao Shi, Baichuan Wang, Kaige Ma, Zengwu Shao.
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Hydrogen peroxide induces programmed necrosis in rat nucleus pulposus cells through the RIP1/RIP3-PARP-AIF pathway.
Journal of Orthopaedic Research.
28 September 2017.
(IF 3.043)
1139. Zhang Z, Li S, Jiang H, Liu B, Lv Z, Guo C, Zhang H.
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Effects of selenium on apoptosis and abnormal amino acid metabolism induced by excess fatty acid in isolated rat hepatocytes.
Mol Nutr Food Res.
2017 Sep;61(9).
(IF 5.309)
1140. Zhou K, Luo X, Wang Y, Cao D, Sun G.
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MicroRNA-30a suppresses tumor progression by blocking Ras/Raf/MEK/ERK signaling pathway in hepatocellular carcinoma.
Biomed Pharmacother.
2017 Sep;93:1025-1032.
(IF 4.545)
1141. Yuan Liu, Dexiang Liu, Jingjing Xu, Hong Jiang, Fang Pan.
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Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats.
Developmental Psychobiology.
25 September 2017.
(IF 1.855)
1142. Guo XQ, Cao YL, Hao F, Yan ZR, Wang ML, Liu XW.
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Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway.
ADV MED SCI-POLAND.
2017 Sep;62(2):246-253.
(IF 2.57)
1143. Biao Ding, Liang-Ze Wan, Yu-Qing Zhang.
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Biosafety Evaluation of Three Sodium Lauryl N‐Amino Acids Synthesized from Silk Industrial Waste in Mice.
JOURNAL OF SURFACTANTS AND DETERGENTS.
Volume20, Issue5, September 2017, Pages 1173-1187.
(IF 1.672)
1144. Zhao H, Duan Q, Zhang Z, Li H, Wu H, Shen Q, Wang C, Yin T.
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Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells.
J Cell Mol Med.
2017 Sep;21(9):2055-2067.
(IF 4.486)
1145. Juan Li, Chun-Xia Zhang, Yi-Mei Liu, Ke-Li Chen, Gang Chen.
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A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction.
ONCOTARGET.
2017 Sep 12; 8(39): 65717–65729.
(IF 5.168)
1146. Lu-Lu Wang, Lan-Bo Zhou, Jin Shu, Nan-Nan Li, Hui-Wen Zhang, Rui Jin, Li-Li Zhuang, Guo-Ping Zhou.
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Up-regulation of IRF-3 expression through GATA-1 acetylation by histone deacetylase inhibitor in lung adenocarcinoma A549 cells.
ONCOTARGET.
2017 Sep 29; 8(44): 75943–75951.
(IF 5.168)
1147. Zheng H, Wu J, Shi J, Lu C, Wang Y, Sun Q, Zhang G, Zhao G.
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miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9.
Oncol Rep.
2017 Sep;38(3):1790-1796.
(IF 3.417)
1148. Zhang D, Wang F, Pang Y, Ke XX, Zhu S, Zhao E, Zhang K, Chen L, Cui H.
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Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction.
ONCOTARGET.
2017 Sep 15;8(46):80956-80970.
(IF 5.168)
1149. Hong Yang, Fei Huang, Yulong Tao, Xinbin Zhao, Lina Liao, Xia Tao.
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Simvastatin ameliorates ionizing radiation-induced apoptosis in the thymus by activating the AKT/sirtuin 1 pathway in mice.
International Journal of Molecular Medicine.
September 2017, Volume 40 Issue 3.
(IF 2.928)
1150. Yuan Xu, Yi-Fan Han, Shao-Jun Zhu, Jian-Da Dong, Bing Ye.
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miRNA-148a inhibits cell growth of papillary thyroid cancer through STAT3 and PI3K/AKT signaling pathways.
Oncology Reports.
September 7, 2017.
(IF 3.041)
1151. Yuan Q, Cao G, Li J, Zhang Y, Yang W.
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MicroRNA-136 inhibits colon cancer cell proliferation and invasion through targeting liver receptor homolog-1/Wnt signaling.
Gene.
2017 Sep 10;628:48-55.
(IF 2.984)
1152. Jiangang Wang, Bing Xiao, Fang Han, Yuxiu Shi.
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Metformin Alleviated the Neuronal Oxidative Stress in Hippocampus of Rats under Single Prolonged Stress.
Journal of Molecular Neuroscience.
September 2017, Volume 63, Issue 1, pp 28–35.
(IF 2.577)
1153. Gong G, An F, Wang Y, Bian M, Yu LJ, Wei C.
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miR-15b represses BACE1 expression in sporadic Alzheimer's disease.
ONCOTARGET.
2017 Sep 21;8(53):91551-91557.
(IF 5.168)
1154. Zhu X, Zhou Y, Cai W, Sun H, Qiu L.
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Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.
BIOCHEM BIOPH RES CO.
2017 Sep 16;491(2):515-521.
(IF 2.985)
1155. Juying Liu, Wei Chen, Zhenzhang Chen, Jing Wen, Hongliang Yu, Feijiang Wang, Lirong Wu, Xia He.
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The effects of microRNA-98 inhibits cell proliferation and invasion by targeting STAT3 in nasopharyngeal carcinoma.
Biomedicine & Pharmacotherapy.
Volume 93, September 2017, Pages 869-878.
(IF 3.743)
1156. Li J, Qian C, Zhou Q, Li J, Li K, Yi P.
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BEBT-908: A novel potent PI3K/HDAC inhibitor against diffuse large B-cell lymphoma.
BIOCHEM BIOPH RES CO.
2017 Sep 30;491(4):939-945.
(IF 2.985)
1157. Qinjun Chu, Dan Shen, Long He, Hongwei Wang, Chunlan Liu, Wei Zhang.
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Prognostic significance of SOCS3 and its biological function in colorectal cancer.
Gene.
Volume 627, 5 September 2017, Pages 114-122.
(IF 2.984)
1158. Yawen Ma, Yixue Xue, Xiaobai Liu, Chengbin Qu, Heng Cai, Ping Wang, Zhiqing Li, Zhen Li, Yunhui Liu.
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SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153.
Oncology Reports.
September 21, 2017.
(IF 3.041)
1159. Nan-Qi Zhang, Cui-Zhu Wang, Zhen-zhou Wang, Zhuo Li, Jing-Ying Sai, Yan Meng, Fang Wang, Ping-Ya Li, Jin-Ping Liu.
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Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation.
Journal of Functional Foods.
Volume 36, September 2017, Pages 224-232.
(IF 3.197)
1160. Duan WN, Xia ZY, Liu M, Sun Q, Lei SQ, Wu XJ, Meng QT, Leng Y.
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Protective effects of SOCS3 overexpression in high glucose‑induced lung epithelial cell injury through the JAK2/STAT3 pathway.
Mol Med Rep.
2017 Sep;16(3):2668-2674.
(IF 2.1)
1161. Liu W, Zhang B, Chen G, Wu W, Zhou L, Shi Y, Zeng Q, Li Y, Sun Y, Deng X, Wang F.
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Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer.
Mol Ther.
2017 Sep 6;25(9):2129-2139.
(IF 8.986)
1162. Lu C, Cui C, Liu B, Zou S, Song H, Tian H, Zhao J, Li Y.
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FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated Wnt signaling.
Neurosci Lett.
2017 Sep 14;657:77-83.
(IF 2.274)
1163. Bin Feng, Meng R, Bin Huang, Bi Y, Shen S, Zhu D.
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Silymarin protects against renal injury through normalization of lipid metabolism and mitochondrial biogenesis in high fat-fed mice.
FREE RADICAL BIO MED.
2017 Sep;110:240-249.
(IF 6.17)
1164. Sun Q, Shen ZY, Duan WN, Meng QT, Xia ZY.
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Mechanism of myocardial ischemia/reperfusion-induced acute kidney injury through DJ-1/Nrf2 pathway in diabetic rats.
Exp Ther Med.
2017 Nov;14(5):4201-4207. doi: 10.3892/etm.2017.5095. Epub 2017 Sep 1.
(IF 1.785)
1165. Guan H, Piao H, Qian Z, Zhou X, Sun Y, Gao C, Li S, Piao F.
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2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway.
Mol Biosyst.
2017 Sep 26;13(10):1993-2005.
(IF 3.336)
1166. Zhang L, Zhou L, Song X, Liang G, Xu Z, Wang F, Huang F, Jiang G.
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Involvement of exogenous 3‑deoxyglucosone in β-cell dysfunction induces impaired glucose regulation.
Mol Med Rep.
2017 Sep;16(3):2976-2984.
(IF 2.1)
1167. Li HH, Sun YL, Cui DM, Wu J, Zeng JW.
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Effect of dopamine on bone morphogenesis protein-2 expression in human retinal pigment epithelium.
INT J OPHTHALMOL-CH.
2017 Sep 18;10(9):1370-1373.
(IF 1.166)
1168. Gu CJ, Cheng J, Zhang B, Yang SL, Xie F, Sun JS, Huang LQ, Yu JJ, Li MQ.
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Protopanaxadiol and metformin synergistically inhibit estrogen-mediated proliferation and anti-autophagy effects in endometrial cancer cells.
Am J Transl Res.
2017 Sep 15;9(9):4071-4082. eCollection 2017.
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1169. Shao P, Qu WK, Wang CY, Tian Y, Ye ML, Sun DG, Sui JD, Wang LM, Fan R, Gao ZM.
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MicroRNA-205-5p regulates the chemotherapeutic resistance of hepatocellular carcinoma cells by targeting PTEN/JNK/ANXA3 pathway.
Am J Transl Res.
2017 Sep 15;9(9):4300-4307. eCollection 2017.
(IF 3.375)
1170. Luo K, Chen P, Li S, Li W, He M, Wang T, Chen J.
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Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats.
Exp Ther Med.
2017 Sep;14(3):2355-2360.
(IF 1.785)
1171. Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Lingzhi Wang, Xiangyu Wang, Tian Tian.
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Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/β-catenin signaling.
ONCOTARGET.
2017 Sep 19; 8(41): 69983–69994.
(IF 5.168)
1172. Li X, Cheng Q, Li J, He Y, Tian P, Xu C.
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Significance of hydrogen sulfide in sepsis-induced myocardial injury in rats.
Exp Ther Med.
2017 Sep;14(3):2153-2161.
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1173. Feng Z, Zheng W, Li X, Lin J, Xie C, Li H, Cheng L, Wu A, Ni W.
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Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.
Int Immunopharmacol.
2017 Sep;50:161-167.
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1174. Yang H, Zhao N, Lv L, Yan X, Hu S, Xu T.
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Functional research and molecular mechanism of Kainic acid-induced denitrosylation of thioredoxin-1 in rat hippocampus.
Neurochem Int.
2017 Sep;108:448-456.
(IF 3.881)
1175. Dang Y, Zhao Q, Luo B, Pan L, Wei Q, Zhang R, Fan Q, Chen J, Chang R, Zhang J, Li Z.
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Effects of acrylonitrile-induced oxidative stress on testicular apoptosis through activation of NF-κB signaling pathway in male sprague dawley rats.
Am J Transl Res.
2017 Sep 15;9(9):4227-4235. eCollection 2017.
(IF 3.375)
1176. P Gao, X‐H Qiao, L‐M Gou, Y Huang, Q‐H Li, L‐J Li, X‐Y Wang, C‐J Li.
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TGF‐β1 attenuated branching morphogenesis of embryonic murine submandibular gland through Smad3 activation.
Anatomia Histologia Embryologia.
07 September 2017.
(IF 0.657)
1177. Wu XL, Yang ZW, He L, Dong PD, Hou MX, Meng XK, Zhao HP, Wang ZY, Wang F, Baoluri, Wurenqimuge, Agudamu, Jia YF, Shi L.
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RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis.
ONCOTARGET.
2017 Sep 15;8(47):82968-82980.
(IF 5.168)
1178. Ma J, Hu X, Li J, Wu D, Lan Q, Wang Q, Tian S, Dong W.
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Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene.
ONCOTARGET.
2017 Sep 8;8(49):85926-85939.
(IF 5.168)
1179. Yin M, Zhang P, Yu F, Zhang Z, Cai Q, Lu W, Li B, Qin W, Cheng M, Wang H, Gao H.
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Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice.
Mol Med Rep.
2017 Sep;16(3):2844-2850.
(IF 2.1)
1180. Zhongkun Ren, Rongping Zhang, Yuanyuan Li, Yu Li, Zhiyong Yang, Hui Yang.
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Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo.
International Journal of Molecular Medicine.
September 7, 2017.
(IF 2.928)
1181. Gan F, Zhou Y, Hou L, Qian G, Chen X, Huang K.
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Ochratoxin A induces nephrotoxicity and immunotoxicity through different MAPK signaling pathways in PK15 cells and porcine primary splenocytes.
Chemosphere.
2017 Sep;182:630-637.
(IF 5.778)
1182. Xianli Ma, Shengjin Qi, Zhenying Duan, Hongzhan Liao, Baohua Yang, Wenbo Wang, Jie Tan, Qinghua Li, Xuewei Xia.
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Long non‐coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR‐31 expression.
Cell Proliferation.
30 September 2017.
(IF 5.039)
1183. Wang J, Zhou J, Wang Y, Yang C, Fu M, Zhang J, Han X, Li Z, Hu K, Ge J.
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Qiliqiangxin protects against anoxic injury in cardiac microvascular endothelial cells via NRG-1/ErbB-PI3K/Akt/mTOR pathway.
J Cell Mol Med.
2017 Sep;21(9):1905-1914.
(IF 4.486)
1184. Yan P, Bai L, Lu W, Gao Y, Bi Y, Lv G.
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Regulation of autophagy by AMP-activated protein kinase/sirtuin 1 pathway reduces spinal cord neurons damage.
Iran J Basic Med Sci.
2017 Sep;20(9):1029-1036.
(IF 2.146)
1185. Wen X, Xiao L, Zhong Z, Wang L, Li Z, Pan X, Liu Z.
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Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells.
ONCOTARGET.
2017 Sep 3;8(41):69370-69385.
(IF 5.168)
1186. Hou L, Meng M, Chen Y, Wang C.
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A water-soluble polysaccharide from Grifola frondosa induced macrophages activation via TLR4-MyD88-IKKβ-NF-κB p65 pathways.
ONCOTARGET.
2017 Sep 23;8(49):86604-86614.
(IF 5.168)
1187. Xiaolei Li, Hui Chen, Yu Sun, Jihang Dai, Shuguang Wang, Jingcheng Wang, Lianqi Yan.
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Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway.
European Journal of Pharmacology.
5 September 2017, Pages 36-43.
(IF 3.17)
1188. Wang H, Sun R, Chi Z, Li S, Hao L.
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Silencing of Y-box binding protein-1 by RNA interference inhibits proliferation, invasion, and metastasis, and enhances sensitivity to cisplatin through NF-κB signaling pathway in human neuroblastoma SH-SY5Y cells.
Mol Cell Biochem.
2017 Sep;433(1-2):1-12.
(IF 2.795)
1189. Jiang L, Xu G, Li Z, Zeng X, Li Z, Liu J, Mei L, Li X.
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RNAi-mediated knockdown of CAIX enhances the radiosensitivity of nasopharyngeal carcinoma cell line, CNE-2.
ONCOTARGETS THER.
2017 Sep 25;10:4701-4709.
(IF 3.337)
1190. Yang C, Zhang JJ, Peng YP, Zhu Y, Yin LD, Wei JS, Gao WT, Jiang KR, Miao Y.
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A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells.
J Transl Med.
2017 Oct 19;15(1):211.
(IF 4.124)
1191. Xu Q, Liu X, Wang X, Hua Y, Wang X, Chen J, Li J, Wang Y, Stoeger T, Chen S, Huang N.
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Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.
Immunol Res.
2017 Oct;65(5):1065-1073.
(IF 2.507)
1192. Zhang CH, Zheng L, Gui L, Lin JY, Zhu YM, Deng WS, Luo M.
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Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats.
CLIN RES HEPATOL GAS.
2017 Oct 11. pii: S2210-7401(17)30187-0.
(IF 2.718)
1193. Kang H, Yang K, Xiao L, Guo L, Guo C, Yan Y, Qi J, Wang F, Ryffel B, Li C, Deng L.
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Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway.
Front Immunol.
2017 Oct 16;8:1312.
(IF 5.085)
1194. Xiaoyan Li, Yuansheng Ding, Naiqing Liu, Qinli Sun, Jie Zhang.
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MicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway.
Molecular Medicine Reports.
October 17, 2017.
(IF 1.851)
1195. Geng YD, Zhang C, Lei JL, Yu P, Xia YZ, Zhang H, Yang L, Kong LY.
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Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer.
Biochem Pharmacol.
2017 Oct 15;142:71-86.
(IF 4.96)
1196. Feng Z, Li X, Lin J, Zheng W, Hu Z, Xuan J, Ni W, Pan X.
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Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes.
Food Funct.
2017 Oct 18;8(10):3737-3744.
(IF 4.171)
1197. Xiancai Ge, Haiyan Cui, Yanbing Zhou, Deying Yin, Yuanyuan Feng, Qun Xin, Xianhui Xu, Weijing Liu, Shanglong Liu, Qin Zhang.
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miR-320a modulates cell growth and chemosensitivity via regulating ADAM10 in gastric cancer.
Molecular Medicine Reports.
October 19, 2017.
(IF 1.851)
1198. Mingqi Qu, Ju Yu, Hongyuan Liu, Ying Ren, Chunxiao Ma, Xingyao Bu, Qing Lan.
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The Candidate Tumor Suppressor Gene SLC8A2 Inhibits Invasion, Angiogenesis and Growth of Glioblastoma.
Mol Cells.
2017 Oct 31; 40(10): 761–772.
(IF 4.081)
1199. Qi B, Hu L, Zhu L, Shang L, Wang X, Liu N, Wen N, Hong Y, Fang D.
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Metformin Attenuates Neurological Deficit after Intracerebral Hemorrhage by Inhibiting Apoptosis, Oxidative Stress and Neuroinflammation in Rats.
Neurochem Res.
2017 Oct;42(10):2912-2920.
(IF 3.038)
1200. Jingjing Shen, Yaoguang Chang, Shujun Dong, Feng Chen.
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Cloning, expression and characterization of a ι-carrageenase from marine bacterium Wenyingzhuangia fucanilytica: A biocatalyst for producing ι-carrageenan oligosaccharides.
Journal of Biotechnology.
Volume 259, 10 October 2017, Pages 103-109.
(IF 3.163)
1201. Wang XY, Li YL, Wang HY, Zhu M, Guo D, Wang GL, Gao YT, Yang Z, Li T, Yang CY, Chen YM.
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Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca2+ permeable AMPA receptor-system xc- pathway.
Toxicol In Vitro.
2017 Oct;44:57-65.
(IF 2.959)
1202. Feng Xu, Xiao-Chun Liu, Li Li, Chao-Nan Ma, Ya-Jun Zhang.
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Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease.
MEDICINE.
2017 Oct; 96(43): e8166.
(IF 1.552)
1203. Zhao Y, Wu X, Qian L, Guo L, Liao J, Wu X.
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Activating transcription factor 3 protects mice against pseudomonas aeruginosa-induced acute lung injury by interacting with lipopolysaccharide binding protein.
Mol Immunol.
2017 Oct;90:27-32.
(IF 3.641)
1204. Jiang J.
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Diaphanous-related formin-3 overexpression inhibits the migration and invasion of triple-negative breast cancer by inhibiting RhoA-GTP expression.
Biomed Pharmacother.
2017 Oct;94:439-445.
(IF 4.545)
1205. Liu C, Hu W, Cheng T, Peng Z, Mita K, Xia Q.
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Osiris9a is a major component of silk fiber in lepidopteran insects.
INSECT BIOCHEM MOLEC.
2017 Oct;89:107-115.
(IF 3.827)
1206. Li CY, Wang YH, Lin ZY, Yang LW, Gao SL, Liu T, Zou BA, Pan ZC, Song ZQ, Liu G.
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MiR-5100 targets TOB2 to drive epithelial-mesenchymal transition associated with activating smad2/3 in lung epithelial cells.
Am J Transl Res.
2017 Oct 15;9(10):4694-4706. eCollection 2017.
(IF 3.375)
1207. Liu Y, Shi F, Bo L, Zhi W, Weng J, Qu S.
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A novel alginate-encapsulated system to study biological response to critical-sized wear particles of UHMWPE loaded with alendronate sodium.
MAT SCI ENG C-MATER.
2017 Oct 1;79:679-686.
(IF 5.88)
1208. Xie L, Liu S, Cheng J, Wang L, Liu J, Gong J.
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Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway.
REGUL TOXICOL PHARM.
2017 Oct;89:148-154.
(IF 2.652)
1209. Hao Y, Zheng C, Wang L, Zhang J, Niu X, Song Q, Feng Q, Zhao H, Li L, Zhang H, Zhang Z, Zhang Y.
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Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging.
Acta Biomater.
2017 Oct 15;62:293-305.
(IF 7.242)
1210. Wang N, Tian X, Chen Y, Tan HQ, Xie PJ, Chen SJ, Fu YC, Chen YX, Xu WC, Wei CJ.
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Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice.
SCI REP-UK.
2017 Oct 31;7(1):14707.
(IF 3.998)
1211. Liu H, Zhai J, Wang B, Fang M.
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Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
MED SCI MONITOR.
2017 Oct 9;23:4834-4840.
(IF 1.918)
1212. Li-Li Mei, Wen-Jun Wang, Yun-Tan Qiu, Xiu-Feng Xie, Jie Bai, Zhi-Zhou Shi.
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miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma.
PLOS ONE.
October 2, 2017.
(IF 2.74)
1213. Han Q, Li L, Liang H, Li Y, Xie J, Wang Z.
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Downregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells.
MED SCI MONITOR.
2017 Oct 6;23:4798-4807.
(IF 1.918)
1214. Yang Y, Zhao L, Ma J.
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Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism.
Eur J Pharmacol.
2017 Oct 15;813:130-139.
(IF 3.263)
1215. Jianyou Zhang, Hui Liu, Shitong Li, Jin Wu, Jianhong Sun.
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SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.
Molecular Medicine Reports.
October 2017, Volume 16 Issue 4.
(IF 1.851)
1216. Tuo YL, Ye YF.
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MGP is downregulated due to promoter methylation in chemoresistant ER+ breast cancer and high MGP expression predicts better survival outcomes.
EUR REV MED PHARMACO.
2017 Oct;21(17):3871-3878.
(IF 3.024)
1217. Lixia Mao, Lunguo Xia, Jiang Chang, Jiaqiang Liu, Lingyong Jiang, Chengtie Wu, Bing Fang.
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The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration.
Acta Biomaterialia.
Volume 61, 1 October 2017, Pages 217-232.
(IF 6.638)
1218. Zhang TT, Zhang GM, Jin YH, Guo YX, Wang Z, Fan YX, El-Samahy MA, Wang F.
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Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway.
Tissue Cell.
2017 Oct;49(5):603-611.
(IF 1.837)
1219. Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, Li M, Xu L, Dong Z.
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Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
FRONT NEUROSCI-SWITZ.
2017 Oct 26;11:583.
(IF 3.707)
1220. He X, Wu C, Cui Y, Zhu H, Gao Z, Li B, Hua J, Zhao B.
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The aldehyde group of gossypol induces mitochondrial apoptosis via ROS-SIRT1-p53-PUMA pathway in male germline stem cell.
ONCOTARGET.
2017 Oct 24;8(59):100128-100140.
(IF 5.168)
1221. Guo X, Yan F, Shan X, Li J, Yang Y, Zhang J, Yan X, Bu P.
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SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through β-catenin/PPAR-γ signaling.
Life Sci.
2017 Oct 1;186:111-117.
(IF 3.647)
1222. Zhang C, Lin J, Ge J, Wang LL, Li N, Sun XT, Cao HB, Li JL.
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Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis.
Toxicol In Vitro.
2017 Oct;44:349-356.
(IF 2.959)
1223. Zhang M, Ai WW, Mei ZL, Hu YH, Zhang ZL.
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Delivery of biotinylated IGF-1 with biotinylated self-assembling peptides combined with bone marrow stem cell transplantation promotes cell therapy for myocardial infarction.
Exp Ther Med.
2017 Oct;14(4):3441-3446.
(IF 1.785)
1224. Hu Y, Deng C, Zhang H, Zhang J, Peng B, Hu C.
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Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer.
ONCOTARGET.
2017 Oct 10;8(55):94554-94568.
(IF 5.168)
1225. Jian X, Huang W, Wu D, You D, Lin Z, Chen J.
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Effect of Fibronectin-Coated Micro-Grooved Titanium Surface on Alignment, Adhesion, and Proliferation of Human Gingival Fibroblasts.
MED SCI MONITOR.
2017 Oct 4;23:4749-4759.
(IF 1.918)
1226. Du J, Yang P, Kong F, Liu H.
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Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells.
ONCOTARGET.
2017 Oct 10;8(60):101922-101935.
(IF 5.168)
1227. Guo R, Lv Y, Ouyang Y, Liu S, Li D.
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The Role of miR-497/EIF3A Axis in TGFβ1-Induced Epithelial-Mesenchymal Transition and Extracellular Matrix in Rat Alveolar Epithelial Cells and Pulmonary Fibroblasts.
J Cell Biochem.
2017 Oct;118(10):3401-3408.
(IF 4.237)
1228. Zhang CG, Yang SD, Zhu WJ, You BG, Liu Y, Yuan ZQ, Chen WL, Li JZ, Zhou XF, Liu C, Zhang XN.
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Distinctive polymer micelle designed for siRNA delivery and reversal of MDR1 gene-dependent multidrug resistance.
J BIOMED MATER RES B.
2017 Oct;105(7):2093-2106.
(IF 2.831)
1229. Jiang S, Huang Y, Qi Y, He R, Liu Z, Ma Y, Guo X, Shao Y, Sun Z, Ruan Q.
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Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA.
Virol Sin.
2017 Oct;32(5):431-439.
(IF 3.242)
1230. Wang Z, Bu J, Yao X, Liu C, Shen H, Li X, Li H, Chen G.
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Phosphorylation at S153 as a Functional Switch of Phosphatidylethanolamine Binding Protein 1 in Cerebral Ischemia-Reperfusion Injury in Rats.
Front Mol Neurosci.
2017 Oct 31;10:358.
(IF 4.057)
1231. Gao F, Liu W, Guo Q, Bai Y, Yang H, Chen H.
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Physcion blocks cell cycle and induces apoptosis in human B cell precursor acute lymphoblastic leukemia cells by downregulating HOXA5.
Biomed Pharmacother.
2017 Oct;94:850-857.
(IF 4.545)
1232. Lou Y, Wang C, Tang Q, Zheng W, Feng Z, Yu X, Guo X, Wang J.
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Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies.
Inflammation.
2017 Oct;40(5):1698-1706.
(IF 3.212)
1233. Zhou X, Han TL, Chen H, Baker PN, Qi H, Zhang H.
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Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Exp Cell Res.
2017 Oct 1;359(1):195-204.
(IF 3.383)
1234. Tang M, Jiang L, Lin Y, Wu X, Wang K, He Q, Wang X, Li W.
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Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition.
ONCOTARGET.
2017 Oct 27;8(57):97464-97475.
(IF 5.168)
1235. Jiang Y, Ren W, Wang W, Xia J, Gou L, Liu M, Wan Q, Zhou L, Weng Y, He T, Zhang Y.
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Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex.
Oncol Rep.
2017 Nov;38(5):2597-2606.
(IF 3.417)
1236. Lai Q, Luo Z, Wu C, Lai S, Wei H, Li T, Wang Q, Yu Y.
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Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy.
Int Immunopharmacol.
2017 Nov;52:15-23.
(IF 3.943)
1237. Hou Z, Hu Y, Yang X, Chen W.
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Antihypertensive effects of Tartary buckwheat flavonoids by improvement of vascular insulin sensitivity in spontaneously hypertensive rats.
Food Funct.
2017 Nov 15;8(11):4217-4228.
(IF 4.171)
1238. Mingnan Cao, Huixia Wang, Limei Guo, Simin Yang, Chun Liu, Tin Oo Khor, Siwang Yu, Ah-Ng Kong.
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Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling.
AAPS J.
November 2017, Volume 19, Issue 6, pp 1703–1714.
(IF 3.737)
1239. Xueyan Liang, Yufang Yang, Zhenguang Huang, Jinling Zhou, Yue’e Li, Xiaobin Zhong.
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Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α.
ONCOTARGET.
2017 Nov 28; 8(61): 102989–103003.
(IF 5.168)
1240. Yujie Liu, Jianwei Pan, Lifang Liu, Wei Li, Ran Tao, Yinghu Chen, Huamei Li, Shiqiang Shang.
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The influence of HCMV infection on autophagy in THP-1 cells.
MEDICINE.
2017 Nov; 96(44): e8298.
(IF 1.552)
1241. Wenyu Xin, Qiaoyun Wang, Dan Zhang, Chaoyun Wang.
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A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway.
European Journal of Pharmacology.
Volume 814, 5 November 2017, Pages 240-247.
(IF 3.17)
1242. Mengchen Shi, Lina Zhou, Lu Zhao, Mei Shang, Tongtong He, Zeli Tang, Hengchang Sun, Pengli Ren, Zhipeng Lin, Tingjin Chen, Jinyun Yu, Jin Xu, Xinbing Yu, Yan Huang.
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Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2 + dyshomeostasis in hepatocarcinoma PLC cells.
PLOS Neglected Tropical Diseases.
November 10, 2017.
(IF 4.487)
1243. Wu N, Hui H, Cui L, Yang F.
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GRIM-19 represses the proliferation and invasion of cutaneous squamous cell carcinoma cells associated with downregulation of STAT3 signaling.
Biomed Pharmacother.
2017 Nov;95:1169-1176.
(IF 4.545)
1244. Liu H, Yue Q, He S.
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Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2.
Life Sci.
2017 Nov 15;189:96-105.
(IF 3.647)
1245. Han H, Gu S, Chu W, Sun W, Wei W, Dang X, Tian Y, Liu K, Chen J.
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miR-17-5p Regulates Differential Expression of NCOA3 in Pig Intramuscular and Subcutaneous Adipose Tissue.
Lipids.
2017 Nov;52(11):939-949.
(IF 1.919)
1246. Zhihui Huang, Naidong Zhang, Wenming Ma, Xiaoyu Dai, Jinbo Liu.
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MiR-337-3p promotes chondrocytes proliferation and inhibits apoptosis by regulating PTEN/AKT axis in osteoarthritis.
Biomedicine & Pharmacotherapy.
Volume 95, November 2017, Pages 1194-1200.
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1247. Du WL, Fang Q, Chen Y, Teng JW, Xiao YS, Xie P, Jin B, Wang JQ.
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Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells.
Mol Med Rep.
2017 Nov;16(5):6050-6058.
(IF 2.1)
1248. Zhao L, Liu S, Xu J, Li W, Duan G, Wang H, Yang H, Yang Z, Zhou R.
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A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells.
Cell Death Dis.
2017 Nov 2;8(11):e3160.
(IF 6.304)
1249. Shengwei Liu, Shuang Chen, Weiguang Yuan, Hongyan Wang, Kewang Chen, Dianjun Li, Dalin Li.
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PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways.
ONCOTARGET.
2017 Nov 21; 8(59): 99901–99912.
(IF 5.168)
1250. Shang H, Wang Y, Chao X, Sun G, Bai X, Xu L, Han Y, Li J, Wang H, Fan Z.
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Artemin transiently increases iNOS expression in primary cultured trigeminal ganglion neurons.
Neurosci Lett.
2017 Nov 1;660:34-38.
(IF 2.274)
1251. Li J, Xu R, Lu X, He J, Jin S.
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A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance.
INT J NANOMED.
2017 Nov 1;12:8043-8056.
(IF 5.115)
1252. Xiaoliang Chen, Yanhong Liu, Yanhong Shan, Xingyi Jin, Qingyang Shi, Chunshu Jia.
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Oxidized low‐density lipoprotein suppresses mouse granulosa cell differentiation through disruption of the hypoxia‐inducible factor 1 pathway.
Early View.
20 November 2017.
1253. Fan H, Ma X, Lin P, Kang Q, Zhao Z, Wang L, Sun D, Cheng J, Li Y.
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Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats.
MED SCI MONITOR.
2017 Nov 24;23:5599-5612.
(IF 1.918)
1254. Lin H, Ma X, Wang BC, Zhao L, Liu JX, Pu FF, Hu YQ, Hu HZ, Shao ZW.
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Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells.
Life Sci.
2017 Nov 15;189:76-83.
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1255. Liu L, Li N, Zhang Q, Zhou J, Lin L, He X.
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Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-β1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition.
Oncol Res.
2017 Nov 2;25(9):1607-1616.
(IF 4.949)
1256. Liu C, Wu H, Li Y, Shen L, Yu R, Yin H, Sun T, Sun C, Zhou Y, Du Z.
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SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway.
NEURO-ONCOLOGY.
2017 Nov;135(2):263-272.
(IF 10.247)
1257. Shi J, Zhao W, Ying H, Zhang Y, Du J, Chen S, Li J, Shen B.
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Estradiol inhibits NLRP3 inflammasome in fibroblast-like synoviocytes activated by lipopolysaccharide and adenosine triphosphate.
Int J Rheum Dis.
2017 Nov 3.
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1258. Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z.
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Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.
Asian J Androl.
2017 Nov 7.
(IF 2.448)
1259. Pan T, Wu D, Cai N, Chen R, Shi X, Li B, Pan J.
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Alpha-Mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model.
Int Immunopharmacol.
2017 Nov;52:34-43.
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1260. Gong JH, Gong JP, Zheng KW.
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Checking transfer efficiency and equal loading via qualitative optical way in western blotting.
Electrophoresis.
2017 Nov;38(21):2786-2790.
(IF 3.081)
1261. Zhao H, Tang W, Chen X, Wang S, Wang X, Xu H, Li L.
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The NAMPT/E2F2/SIRT1 axis promotes proliferation and inhibits p53-dependent apoptosis in human melanoma cells.
BIOCHEM BIOPH RES CO.
2017 Nov 4;493(1):77-84.
(IF 2.985)
1262. Li X, Wang S, Dai J, Yan L, Zhao S, Wang J, Sun Y.
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Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway.
Eur J Pharmacol.
2017 Nov 15;815:437-445.
(IF 3.263)
1263. Liang P, Zhong L, Gong L, Wang J, Zhu Y, Liu W, Yang J.
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Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling pathway.
Int J Mol Med.
2017 Nov;40(5):1477-1485.
(IF 3.098)
1264. Fan S, Yang Z, Ke Z, Huang K, Liu N, Fang X, Wang K.
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Downregulation of the long non-coding RNA TUG1 is associated with cell proliferation, migration, and invasion in breast cancer.
Biomed Pharmacother.
2017 Nov;95:1636-1643.
(IF 4.545)
1265. Tao S, Ren Y, Zheng H, Zhao M, Zhang X, Zhu Y, Yang J, Zheng S.
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Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential.
Eur J Pharmacol.
2017 Nov 5;814:56-62.
(IF 3.263)
1266. Fan C, Qiao Y, Tang M.
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Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state.
DRUG DES DEV THER.
2017 Nov 23;11:3343-3354.
(IF 3.216)
1267. Wang SQ, Wang X, Zheng K, Liu KS, Wang SX, Xie CH.
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Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma.
BIOCHEM BIOPH RES CO.
2017 Nov 4;493(1):534-541.
(IF 2.985)
1268. Xu C, He T, Li Z, Liu H, Ding B.
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Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells.
Biomed Pharmacother.
2017 Nov;95:1504-1513.
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1269. Haifeng Zhang, Baoli Hu, Zuopei Wang, Feng Zhang, Haitao Wei, Li Li.
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miR-181c contributes to cisplatin resistance in non-small cell lung cancer cells by targeting Wnt inhibition factor 1.
Cancer Chemotherapy and Pharmacology.
November 2017, Volume 80, Issue 5, pp 973–984.
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1270. Yu L, Wang X, Chen H, Yan Z, Wang M, Li Y.
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Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatment: Role of Redox Imbalance and Neuroprotection by Biochanin A.
FRONT NEUROSCI-SWITZ.
2017 Nov 23;11:657.
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1271. Mingxia Jiang, Haifen Zhang, Lijie Zhai, Bianliang Ye, Yin Cheng, Chengkai Zhai.
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ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-β1 pathway.
Lipids in Health and Disease.
16 November 2017.
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1272. Cao H, Xu H, Zhu G, Liu S.
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Isoquercetin ameliorated hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis via a mitochondrial-dependent pathway.
Biomed Pharmacother.
2017 Nov;95:938-943.
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1273. Lv C, Yuan X, Zeng HW, Liu RH, Zhang WD.
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Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells.
Eur J Pharmacol.
2017 Nov 15;815:487-494.
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1274. Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, Chengshi Quan.
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CLDN6 promotes chemoresistance through GSTP1 in human breast cancer.
Journal of Experimental & Clinical Cancer Research.
7 November 2017.
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1275. Pan S, An L, Meng X, Li L, Ren F, Guan Y.
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MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and invasion and stimulate epithelial-mesenchymal transition via the Wnt/β-catenin pathway.
Exp Ther Med.
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1276. Wang J, Huang J, Wang L, Chen C, Yang D, Jin M, Bai C, Song Y.
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Urban particulate matter triggers lung inflammation via the ROS-MAPK-NF-κB signaling pathway.
J Thorac Dis.
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1277. Qiao X, Wang L, Wang Y, Su X, Qi Y, Fan Y, Peng Z.
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Intermedin inhibits unilateral ureteral obstruction-induced oxidative stress via NADPH oxidase Nox4 and cAMP-dependent mechanisms.
RENAL FAILURE.
2017 Nov;39(1):652-659.
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1278. Tang W, Shen M, Xie J, Liu D, Du M, Lin L, Gao H, Hamaker BR, Xie M.
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Physicochemical characterization, antioxidant activity of polysaccharides from Mesona chinensis Benth and their protective effect on injured NCTC-1469 cells induced by H2O2.
CARBOHYD POLYM.
2017 Nov 1;175:538-546.
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1279. Zhou J, Xu R, Du XZ, Zhou XD, Li Q.
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Saxifragifolin D attenuates phagosome maturation arrest in Mycobacterium tuberculosis-infected macrophages via an AMPK and VPS34-dependent pathway.
AMB Express.
2017 Dec;7(1):11.
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1280. Shuixian Li, Qianyun Zhang, Lichun Zhou, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han.
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Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.
Biomedicine & Pharmacotherapy.
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Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF‑κB pathways.
Mol Med Rep.
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1282. Zhou L, Chen X, Yan J, Li M, Liu T, Zhu C, Pan G, Guo Q, Yang H, Pei M, He F.
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Melatonin at pharmacological concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS.
OSTEOPOROSIS INT.
2017 Dec;28(12):3325-3337.
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1283. Feng Y, Wang N, Xu J, Zou J, Liang X, Liu H, Chen Y.
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Alpha-1-antitrypsin functions as a protective factor in preeclampsia through activating Smad2 and inhibitor of DNA binding 4.
ONCOTARGET.
2017 Dec 5;8(68):113002-113012.
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1284. Zhang Y, Su Y, Zhao Y, Lv G, Luo Y.
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MicroRNA‑720 inhibits pancreatic cancer cell proliferation and invasion by directly targeting cyclin D1.
Mol Med Rep.
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CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs.
Transgenic Research.
December 2017, Volume 26, Issue 6, pp 799–805.
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1286. Jiang H, Bian F, Zhou H, Wang X, Wang K, Mai K, He G.
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Nutrient sensing and metabolic changes after methionine deprivation in primary muscle cells of turbot (Scophthalmus maximus L.).
J Nutr Biochem.
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1287. Qing-chun Lu, Zhuang-hua Rui, Zhong-liang Guo, Wang Xie, Shan Shan, Tao Ren.
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LncRNA-DANCR contributes to lung adenocarcinoma progression by sponging miR‐496 to modulate mTOR expression.
Journal of Cellular and Molecular Medicine.
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1288. Shuo Zhang, Jiali Chang, Chao Lin, Yiran Pan, Kangping Cui, Xiaoyuan Zhang, Peng Liang, Xia Huang.
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Enhancement of methanogenesis via direct interspecies electron transfer between Geobacteraceae and Methanosaetaceae conducted by granular activated carbon.
Bioresource Technology.
Volume 245, Part A, December 2017, Pages 132-137.
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1289. Li H, Liu D, Li C, Zhou S, Tian D, Xiao D, Zhang H, Gao F, Huang J.
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Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit.
Cell Biol Int.
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Characterization and expression analysis of a new small heat shock protein Hsp20.4 from Eimeria tenella.
Experimental Parasitology.
Volume 183, December 2017, Pages 13-22.
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1291. Zhen Yang, Mei-lin Zhu, De-hai Li, Rong Zeng, Bing-nan Han.
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N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway.
Bioorganic & Medicinal Chemistry.
Volume 25, Issue 24, 15 December 2017, Pages 6614-6622.
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1292. Zhi-Zhen Pan, Lian Xu, Bo Liu, Jing Zhang, Zheng Chen, Qing-Xi Chen, Yu-Jing Zhu.
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PxAPN5 serves as a functional receptor of Cry2Ab in Plutella xylostella (L.) and its binding domain analysis.
International Journal of Biological Macromolecules.
Volume 105, Part 1, December 2017, Pages 516-521.
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1293. Tingting Meng, Binbin Lu, Shihong Shao, Ming Yuan, Xuan Liu, Hong Yuan, Xuan Huang, Fuqiang Hu.
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Sequential therapy with redox-responsive glucolipid nanocarrier separately delivering siRNA and doxorubicin to overcome multidrug resistance.
International Journal of Pharmaceutics.
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1294. Xu X, Lv H, Li X, Su H, Zhang X, Yang J.
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Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro.
Biochem Cell Biol.
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1295. Yunmei Huang, Yu Lin, Yinsheng Wu, Jianwei Zeng, Meiya Huang, Shiming Guo, Wenjuan Luo, Haiming Lin, Yanping Lin.
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Molecular mechanisms of the inhibitory effects of jiangu granule-containing serum on RANKL-induced osteoclastogenesis.
Molecular Medicine Reports.
December 2017, Volume 16 Issue 6.
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1296. Nan Wang, Wei Liu, Tao Tan, Chao-Qun Dong, Duan-Yang Lin, Jun Zhao, Chang Yu, Xiao-Ji Luo.
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Notch signaling negatively regulates BMP9-induced osteogenic differentiation of mesenchymal progenitor cells by inhibiting JunB expression.
ONCOTARGET.
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1297. Chang Zhang, Pan Gong, Yan Ye, Lulu Zhang, Minjian Chen, Yanhui Hu, Aihua Gu, Shanshan Chen, Yubang Wang.
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NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells.
Toxicology in Vitro.
Volume 45, Part 1, December 2017, Pages 25-30.
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1298. Shi X, Jiao B, Chen Y, Li S, Chen L.
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MxA is a positive regulator of type I IFN signaling in HCV infection.
J Med Virol.
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Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells.
Mol Cell Biochem.
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Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias.
Neurosci Bull.
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1301. Zhi-qiang Yuan, Wei-liang Chen, Ben-gang You, Yang Liu, Shu-di Yang, Ji-zhao Li, Wen-jing Zhu, Xiao-feng Zhou, Chun Liu, Xue-nong Zhang.
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Multifunctional nanoparticles co-delivering EZH2 siRNA and etoposide for synergistic therapy of orthotopic non-small-cell lung tumor.
Journal of Controlled Release.
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Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation inducedby angiotensin IV.
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Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages.
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Expression and localization of polypeptide N-acetylgalactosaminyltransferase-like protein 5 in the reproductive organs and sperm of Hu sheep.
Anim Reprod Sci.
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Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.
FREE RADICAL BIO MED.
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Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.
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Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use.
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AMB Express.
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MicroRNA-497-5p Suppresses Tumor Cell Growth of Osteosarcoma by Targeting ADP Ribosylation Factor-Like Protein 2.
CANCER BIOTHER RADIO.
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TOXICOL MECH METHOD.
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FISH SHELLFISH IMMUN.
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Cardiotrophin-1 stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through PI3K/Akt-dependent signaling pathways.
Cytotechnology.
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ONCOTARGET.
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PEGylated stereocomplex polylactide coating of stent for upregulated biocompatibility and drug storage.
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Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.
Biomed Pharmacother.
2019 Jan 109:112-119.
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1449. Ran S, Chu M, Gu S, Wang J, Liang J
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Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome.
Int Endod J.
2019 Jan 52(1):44-53.
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1450. Su QQ, Tian YY, Liu ZN, Ci LL, Lv XW
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Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.
Int Immunopharmacol.
2019 Jan 66:52-61.
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1451. Zhao Y, Yan S, Chen L, Shi B, Guo X
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Effect of interaction between leucine and acetate on the milk protein synthesis in bovine mammary epithelial cells.
Anim Sci J.
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1452. Shi B, Li S, Ju H, Liu X, Li D, Li Y
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Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
Life Sci.
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1453. Wang S, Luo Q, Fan P
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Cannabisin F from Hemp (Cannabis sativa) Seed Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia as SIRT1 Modulator.
Int J Mol Sci.
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1454. Du X, Zhang P, Fu H, Ahsan HM, Gao J, Chen Q
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Smart mitochondrial-targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity.
INT J PHARMACOL.
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1455. Yang H, Wang C, Zhang L, Lv J, Ni H
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Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression.
CHEM-BIOL INTERACT.
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1456. Xin Hu, Xiaofang Wu, Bo Zhao, Yongyi Wang
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Scutellarin Protects Human Retinal Pigment Epithelial Cells Against Hydrogen Peroxide (H 2 O 2)-induced Oxidative Damage
Cell Biosci.
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1457. Cao FJ, Xu MX, Zhou BH, Du YS, Yao JH, Zhou L
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Effects of 2-aryl-1-cyano-1,2,3,4-tetrohydroisoquinolines on apoptosis induction mechanism in NB4 and MKN-45 cells.
Toxicol In Vitro.
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1458. Zhai J, Qu X, Zhang Y, Gao H, Tao L, Song Y, Zhang S
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Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1-eNOS pathway.
J BIOCHEM MOL TOXIC.
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1459. Sun Z, Li Q, Hou R, Sun H, Tang Q, Wang H, Hao Z, Kang S, Xu T, Wu S
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Kaempferol-3-O-glucorhamnoside inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo.
TOXICOL APPL PHARM .
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1460. Wang K, Hu S, Wang B, Wang J, Wang X, Xu C
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Genistein protects intervertebral discs from degeneration via Nrf2-mediated antioxidant defense system: An in vitro and in vivo study.
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Silencing MEKK3 attenuates cardiomyocyte injury caused by hypoxia/reoxygenation via the sonic hedgehog pathway.
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Higenamine protects neuronal cells from oxygen-glucose deprivation/reoxygenation-induced injury.
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1463. Hu X, Liang Y, Zhao B, Wang Y
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Thymoquinone protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis.
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1464. Li C, Wang Y, Li L, Han Z, Mao S, Wang G
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Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
CELL STRESS CHAPERON.
2019 Mar 24(2):453-460.
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1465. Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G, Song L
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MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A.
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1466. Wang Y, Zhang M, Li Z, Yue J, Xu M, Zhang Y, Yung KKL, Li R
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Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells.
Chemosphere.
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1467. Cao Q, He Z, Sun WQ, Fan G, Zhao J, Bao N, Ye T
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Improvement of calcium phosphate scaffold osteogenesis in vitro via combination of glutamate-modified BMP-2 peptides.
MAT SCI ENG C-MATER.
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1468. Liang X, Zhang L, Ji Q, Wang B, Wei D, Cheng D
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miR-421 promotes apoptosis and suppresses metastasis of osteosarcoma cells via targeting LTBP2.
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Vet Res.
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miR-203 accelerates apoptosis and inflammation induced by LPS via targeting NFIL3 in cardiomyocytes.
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1471. Wu B, Wu X, Liu S, Wang Z, Chen L
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Chemosphere.
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1472. Wang QL, Guo C, Qi J, Ma JH, Liu FY, Lin SQ, Zhang CY, Xie WD, Zhuang JJ, Li X
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Protective effects of 3β-angeloyloxy-8β, 10β-dihydroxyeremophila-7(11)-en-12, 8α-lactone on paraquat-induced oxidative injury in SH-SY5Y cells.
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S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-κB signaling pathway in mice.
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14-3-3 protein and ubiquitin C acting as SjIAP interaction partners facilitate tegumental integrity in Schistosoma japonicum.
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Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis.
CHEM-BIOL INTERACT.
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Dimethylglycine sodium salt protects against oxidative damage and mitochondrial dysfunction in the small intestines of mice.
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Pathol Res Pract.
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1479. Liu J, Du W
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ONCOTARGETS THER.
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1480. Hu T, Linghu K, Huang S, Battino M, Georgiev MI, Zengin G, Li D, Deng Y, Wang YT, Cao H.
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Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells.
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Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice.
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Berberine suppresses mast cell-mediated allergic responses via regulating FcɛRI-mediated and MAPK signaling.
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PPARγ and mitophagy are involved in hypoxia/reoxygenation-induced renal tubular epithelial cells injury.
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Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions.
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Liver X receptor agonist T0901317 inhibits the migration and invasion of non-small-cell lung cancer cells in vivo and in vitro.
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1486. Han D, Gu X, Gao J, Wang Z, Liu G, Barkema HW, Han B
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Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells.
FREE RADICAL BIO MED.
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NADPH oxidase 1/4 inhibition attenuates the portal hypertensive syndrome via modulation of mesenteric angiogenesis and arterial hyporeactivity in rats.
CLIN RES HEPATOL GAS.
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Suppression of microRNA-141 suppressed p53 to protect against neural apoptosis in epilepsy by SIRT1 expression.
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Paeoniflorin protects pancreatic β cells from STZ-induced damage through inhibition of the p38 MAPK and JNK signaling pathways.
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1490. Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW
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Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice.
BIOCHEM BIOPH RES CO.
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1491. Shen L, Lei S, Huang L, Li S, Yi S, Breitzig M, Huang M, Mo X, Sun H, Zheng Q, Tian J, Czachor A, Wang F
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Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice.
Eur J Pharmacol.
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Anti-CTLA-4 monoclonal antibody improves efficacy of the glyceraldehyde-3-phosphate dehydrogenase protein vaccine against Schistosoma japonicum in mice.
Parasitol Res.
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The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells.
ENVIRON TOXICOL CHEM.
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1494. He ZB, Duan GF, Liang CY, Li HY, Liu JS, Yang WD
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Up-regulation of Nrf2-dependent antioxidant defenses in Perna viridis after exposed to Prorocentrum lima.
FISH SHELLFISH IMMUN.
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1495. Pu Y, Liu Z, Tian H, Bao Y
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The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+/PKC/p38/NF-κB signaling pathway in macrophages.
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Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.
Inflammopharmacology.
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1497. Chen F, Zhou CC, Yang Y, Liu JW, Yan CH
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GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus.
Biol Trace Elem Res.
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1498. Ren J, Li J, Hu J, Yu H, Yang Q, Mu J
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Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition.
Biochimie.
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Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice.
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1500. Wang M, Wang Z, Zhu X, Guan S, Liu Z
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NFKB1-miR-612-FAIM2 pathway regulates tumorigenesis in neurofibromatosis type 1.
IN VITRO CELL DEV-AN.
2019 Aug 55(7):491-500.
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1501. Tian X, Cong F, Guo H, Fan J, Chao G, Song T
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Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling.
CHEM-BIOL INTERACT.
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1502. Liu Q, Shuai M, Xia Y
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Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs.
Cancer Manag Res.
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Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity.
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1505. Zeng YJ, Yang HR, Zong MH, Yang JG, Lou WY
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Novel antibacterial polysaccharides produced by endophyte Fusarium solani DO7.
BIORESOURCE TECHNOL.
2019 Sep 288:121596.
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1506. Cui W, Liu CX, Zhang YC, Shen Q, Feng ZH, Wang J, Lu SF, Wu J, Li JX
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A novel oleanolic acid derivative HA-19 ameliorates muscle atrophy via promoting protein synthesis and preventing protein degradation.
TOXICOL APPL PHARM .
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1507. Shi R, Su WW, Zhu ZT, Guan MY, Cheng KL, Fan WY, Wei GY, Li PB, Yang ZY, Yao HL
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Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion.
Phytomedicine.
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Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells.
Immunol Res.
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Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Phytother Res.
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1510. Wang X, Lu S, He C, Wang C, Wang L, Piao M, Chi G, Luo Y, Ge P
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RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction.
BIOCHEM BIOPH RES CO.
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1511. Hao Y, Liu HM, Wei X, Gong X, Lu ZY, Huang ZH
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Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission.
Acta Diabetol.
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1512. Yuan L, Zhao H, Liu L, Peng S, Li H, Wang H
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Heterologous expression of the puuE from Oenococcus oeni SD-2a in Lactobacillus plantarum WCFS1 improves ethanol tolerance.
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1513. Liu W, Ke M, Zhang Z, Lu T, Zhu Y, Li Y, Pan X, Qian H
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Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana.
J ENVIRON SCI-CHINA.
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Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy.
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1515. Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY
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Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Exp Ther Med.
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1516. Li Y, Li R, Ouyang N, Dai K, Yuan P, Zheng L, Wang W
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Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis.
Fertil Steril.
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1517. Guan L, Che Z, Meng X, Yu Y, Li M, Yu Z, Shi H, Yang D, Yu M
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MCU Up-regulation contributes to myocardial ischemia-reperfusion Injury through calpain/OPA-1-mediated mitochondrial fusion/mitophagy Inhibition.
J Cell Mol Med.
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1518. Cao R, Fang D, Wang J, Yu Y, Ye H, Kang P, Li Z, Wang H, Gao Q
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ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation.
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1519. Wenbo Jiang, Bai Li, Yingying Chen, Shuying Gao.
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The toxic influence of dibromoacetic acid on the hippocampus and pre-frontal cortex of rat: involvement of neuroinflammation response and oxidative stress.
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1520. Li H, Di G, Zhang Y, Xue R, Zhang J, Liang J
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MicroRNA-155 and microRNA-181a, via HO-1, participate in regulating the immunotoxicity of cadmium in the kidneys of exposed Cyprinus carpio.
FISH SHELLFISH IMMUN.
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1521. Zhang X, Hu F, Liu L, Xu B
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Effect of silencing of mediator of DNA damage checkpoint protein 1 on the growth of oral squamous cell carcinoma in vitro and in vivo.
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1522. Liu ZN, Jia WQ, Jiang T, Dai JW, Shuai C, Lv XW
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Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation.
Int Immunopharmacol.
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1523. Deng H, Ma J, Liu Y, He P, Dong W
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Combining α-Hederin with cisplatin increases the apoptosis of gastric cancer in vivo and in vitro via mitochondrial related apoptosis pathway.
Biomed Pharmacother.
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1524. Lei M, Ma G, Sha S, Wang X, Feng H, Zhu Y, Du X
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Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance.
Drug Deliv.
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1525. Minjuan Wang, Chengliang Li, Wei Shi
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Stomatin-like protein-2 Confers Neuroprotection Effect in Oxygen-Glucose Deprivation/Reoxygenation-Injured Neurons by Regulating AMPK/Nrf2 Signalling
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1526. Qingqing Li, Xueyan Liang, Yufang Yang, Xian Zeng, Xiaobin Zhong, Chun Huang
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Panax Notoginseng Saponins Ameliorate Cisplatin-Induced Mitochondrial Injury via the HIF-1α/mitochondria/ROS Pathway
FEBS Open Bio.
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1527. Man Luo, Ji-Cheng Huang, Zhan-Qing Yang, Yu-Si Wang, Bin Guo, Zhan-Peng Yue
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Hydroxysafflor Yellow A Exerts Beneficial Effects by Restoring Hormone Secretion and Alleviating Oxidative Stress in Polycystic Ovary Syndrome Mice
Exp Physiol.
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1528. Geng H, Hao L, Cheng Y, Wang C, Huang S, Wei W, Yang R, Li H, Liu S, Yu H, Lu H
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Interaction between CA repeat microsatellites and HIF1α regulated the transcriptional activity of porcine IGF1 promoter.
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1529. Luo M, Yang ZQ, Huang JC, Wang YS, Guo B, Yue ZP
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Genistein protects ovarian granulosa cells from oxidative stress via cAMP-PKA signaling.
Cell Biol Int.
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1530. Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q
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Syringin protects against colitis by ameliorating inflammation.
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1531. Yi L, Juan W, Gang C, Leiming Z, Jianning Z
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Seawater Immersion Aggravates Early Mitochondrial Dysfunction and Increases Neuronal Apoptosis After Traumatic Brain Injury.
Cell Mol Neurobiol.
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1532. Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou
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Effects of differential distributed-JUP on the malignancy of gastric cancer
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1533. Qinghai Meng, Yu Li, Tingting Ji, Ying Chao, Jun Li, Yu Fu, Suyun Wang, Qi Chen, Wen Chen, Fuhua Huang, Youran Wang, Qichun Zhang, Xiaoliang Wang, Huimin Bian
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Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy
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1534. Ning Zhang, Hongdan Xu, Yueying Wang, Yuan Yao, Guoliang Liu, Xia Lei, Huifeng Sun, Xiuhong Wu, Jianmin Li
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Protective mechanism of kaempferol against Aβ25-35-mediated apoptosis of pheochromocytoma (PC-12) cells through the ER/ERK/MAPK signalling pathway
Arch Med Sci.
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1535. Xi He, Wenxiu Xie, Huiling Li, Yiqiang Cui, Ya Wang, Xuejiang Guo, Jiahao Sha
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The testis-specifically expressed gene Trim69 is not essential for fertility in mice
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Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction
Bioact Mater.
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Bnip3 interacts with vimentin, an intermediate filament protein, and regulates autophagy of hepatic stellate cells
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Homoharringtonine Inhibits Alzheimer's Disease Progression by Reducing Neuroinflammation via STAT3 Signaling in APP/PS1 Mice
Neurodegener Dis.
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1540. Zhongyuan Piao, Lin Song, Lifen Yao, Limei Zhang, Yichan Lu
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Schisandrin Restores the Amyloid β-Induced Impairments on Mitochondrial Function, Energy Metabolism, Biogenesis, and Dynamics in Rat Primary Hippocampal Neurons
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1541. Xiao-Wen Lian, Bin Luo
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Knockdown of NEAT1 induced microglial M2 polarization via miR‑374a‑5p/NFAT5 axis to inhibit inflammatory response caused by OGD/R
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1542. Huanzhi Zhao, Shunhai Zhu, Qiping Zhao, Bing Huang, Guiling Liu, Zhihang Li, Lu Wang, Hui Dong, Hongyu Han
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Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
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1543. Hua Fang, Miao Yang, Qin Pan, Hon-Ling Jin, Hua-Feng Li, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhang
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1544. Haibo Xu, Qian Qi, Xixin Yan
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Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model
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1545. Qun Zhao, Yun Bi, Jian Guo, Yingxiang Liu, Jing Zhong, Yongqiang Liu, Longrui Pan, Yang Guo, Yan Tan, Xianjun Yu
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1546. Miao Zhang, Yuan Hu, Jiahui Zhang, Junjian Zhang
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FTY720 Prevents Spatial Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via a SIRT3-Independent Pathway
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1547. Sihong Li, Ruimeng Liu, Gaoqiang Wei, Guifang Guo, Hongxiao Yu, Yixin Zhang, Muhammad Ishfaq, Saqib Ali Fazilani, Xiuying Zhang
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Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression
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1548. Mingda Li, Jie Jia, Shanshan Li, Baocheng Cui, Jiao Huang, Zhaoming Guo, Kun Ma, Li Wang, Changhao Cui
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Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway
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1549. Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu, Zhoubin Li
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Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats
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1551. Xue Wang, Hong Zhu, Lei Lei, Yang Zhang, Chao Tang, Jia-Xing Wu, Jie-Ru Zhou, Xi-Rong Xiao
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Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System
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1552. Meng Xia, Xuena Li, Yao Diao, Bulin Du, Yaming Li
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Targeted inhibition of glutamine metabolism enhances the antitumor effect of selumetinib in KRAS-mutant NSCLC
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1554. Jia-Yan Chen, You-Xiang Wang, Ke-Feng Ren, Yun-Bing Wang, Guo-Sheng Fu, Jian Ji
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1557. Hongwei Lu, Changchang Fu, Suyan Kong, Xudong Wang, Lin Sun, Zeng Lin, Peng Luo, Haidong Jin
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Baicalin attenuates endometritis in a rabbit model induced by infection with Escherichia coli and Staphylococcus aureus via NF-κB and JNK signaling pathways
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1563. Dongliang Zhang, Lan Jiang, Mengling Wang, Meiping Jin, Xuemei Zhang, Difa Liu, Zhangwei Wang, Licai Yang, Xudong Xu
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Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration
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1564. Ning Ma, Xingjie Li, Hongyu Jiang, Yulong Dai, Guofeng Xu, Zongde Zhang
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1565. Wenchao Zhang, Jianwei Liu, Yang Fu, Huifang Ji, Zheyan Fang, Wanming Zhou, Huimin Fan, Yingxuan Zhang, Yan Liao, Ting Yang, Xiaolin Wang, Wanwan Yuan, Xiaoshu Chen, Yi-Fei Dong
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1566. Huan Liu, Huidan Deng, Hengmin Cui, Zhijie Jian, Hongrui Guo, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
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Copper induces hepatocyte autophagy via the mammalian targets of the rapamycin signaling pathway in mice
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1567. Ying Luo, Li-Mei Liu, Li Xie, Hong-Lei Zhao, Yong-Kang Lu, Bao-Quan Wu, Zhi-Ye Wu, Zhi-Ling Zhang, Yun-Ling Hao, Wu-Hua Ou, Rui-Shuang Liu, Wen-Min Xu, Xie-Hui Chen
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1568. Lishen Ren, Dongrui Guo, Xiaohui Wan, Rongfeng Qu
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EYA2 upregulates miR-93 to promote tumorigenesis of breast cancer by targeting and inhibiting the STING signaling pathway
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1569. Fangyuan Jia, Qi Wu, Zhiwei Wang, Min Zhang, Shun Yuan, Yanjia Che, Bowen Li, Zhipeng Hu, Xiaoping Hu
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BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis
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1570. Guoyuan Pan, Huimei Zhang, Anqi Zhu, Yao Lin, Lili Zhang, Bingyun Ye, Jingyan Cheng, Weimin Shen, Lingqin Jin, Chan Liu, Qingfeng Xie, Xiang Chen
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Integrated Proteomic and Transcriptomic Analyses Reveal the Roles of Brucella Homolog of BAX Inhibitor 1 in Cell Division and Membrane Homeostasis of Brucella suis S2
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GABAB receptor antagonist promotes hippocampal neurogenesis and facilitates cognitive function recovery following acute cerebral ischemia in mice
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1574. Gangyin Xie, Linxiao Sun, Yonglin Li, Bicheng Chen, Cheng Wang
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1575. Fang Han, Hui Guo, Leyi Wang, Yuting Zhang, Lin Sun, Chenyang Dai, Xinyi Wu
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1576. Hangwei Fu, Yida Zhang, Yin Chen, Junying Chen, Ping Chen
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CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression
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1577. Jing Zhang, Na Jiang, Jian Ping, Lieming Xu
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TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathways
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1578. Tong Zhou, Bolan Zhou, Yasong Zhao, Qing Li, Guili Song, Zuoyan Zhu, Yong Long, Zongbin Cui
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Development of a Mucus Gland Bioreactor in Loach Paramisgurnus dabryanus
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1579. Ping Lin, Hui-Ru Bai, Ling He, Qiu-Xiang Huang, Qin-Han Zeng, Yuan-Zhi Pan, Bei-Bei Jiang, Fan Zhang, Lei Zhang, Qing-Lin Liu
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1580. Panpan Meng, Yi-Fan Zhang, Wangli Zhang, Xin Chen, Tong Xu, Sheng Hu, Xinjun Liang, Mingqian Feng, Xiaoqing Yang, Mitchell Ho
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Ultra-Conformable Ionic Skin with Multi-Modal Sensing, Broad-Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care
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1582. Run-Ze Yang, Huo-Liang Zheng, Wen-Ning Xu, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang
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1584. Yujing Cao, Qiuxia Lv, Yang Li
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Membrane vesicles from a Dietzia bacterium containing multiple cargoes and their roles in iron delivery
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Global Profiling of 2-hydroxyisobutyrylome in Common Wheat
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Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats
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Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway
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Transcriptomic Data Analyses Reveal That Sow Fertility-Related lincRNA NORFA Is Essential for the Normal States and Functions of Granulosa Cells
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DNAJC12 as a Mediator Between ESR1 and ERBB4 in Breast Carcinoma Cells
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Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway
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Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion
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The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway
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Integration of transcriptomic and proteomic analyses for finger millet [Eleusine coracana (L.) Gaertn.] in response to drought stress
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1611. Qing-Rui Wu, Dan-Lin Zheng, Pei-Ming Liu, Hui Yang, Lu-An Li, Su-Juan Kuang, Ying-Yu Lai, Fang Rao, Yu-Mei Xue, Ji-Jin Lin, Shuang-Xin Liu, Chun-Bo Chen, Chun-Yu Deng
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(IF 6.304)
1612. Yanhong Yang, Changyuan Yang, Zili Lei, Hedong Rong, Siping Yu, Huijuan Wu, Lanxiang Yang, Yuting Lei, Wanwan Liu, Ya Nie, Jiamin Zhu, Jiao Guo
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Cigarette smoking exposure breaks the homeostasis of cholesterol and bile acid metabolism and induces gut microbiota dysbiosis in mice with different diets
Toxicology.
2021 Feb 28;450:152678. doi: 10.1016/j.tox.2021.152678.
(IF 4.099)
1613. Tianyu Zou, Jielin Zhang, Yongxiu Liu, Yiming Zhang, Kazuo Sugimoto, Cheng Mei
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Antidepressant-Like Effect of Geniposide in Mice Exposed to a Chronic Mild Stress Involves the microRNA-298-5p-Mediated Nox1
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(IF 4.057)
1614. Zhiyuan Qin, Haihong Hu, Wen Sun, Lu Chen, Shengnan Jin, Qingwen Xu, Yuxi Liu, Lushan Yu, Su Zeng
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miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells
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1615. Shuang Shen, Juntao Luo, Jianping Ye
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Artesunate alleviates schistosomiasis-induced liver fibrosis by downregulation of mitochondrial complex Ⅰ subunit NDUFB8 and complex Ⅲ subunit UQCRC2 in hepatic stellate cells
Acta Trop.
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(IF 2.555)
1616. Guiting Zhang, Qianqian Cai, Hong Zhou, Chao He, Yudan Chen, Peng Zhang, Ting Wang, Liangjie Xu, Jinchuan Yan
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OxLDL/β2GPI/anti‑β2GPI Ab complex induces inflammatory activation via the TLR4/NF‑κB pathway in HUVECs
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(IF 2.1)
1617. Hongyan Zhang, Feng Su, Libo Huang, Boyu Li, Xuejun Yuan, Mingjiu Luo, Lijiang Ge
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Effects of progesterone on the lipolysis of lipid droplets and prostaglandin E2 synthesis in murine cervical epithelial cells
Reprod Fertil Dev.
2021 Feb;33(3):209-219. doi: 10.1071/RD20195.
1618. Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Ning Liu, Tiejun Liu, Xiaoliu Dong
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Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis
Aging (Albany NY).
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1619. Yanhua Guan, Xu Wang
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Med Sci Monit.
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1620. Xiaohan Gong, Jinzhi Zhang, Caiyun Ge, Yiwen Yi, Shiyun Dai, Guanlan Fan, Changrong Li, Yuanzhen Zhang, Hui Wang, Dan Xu
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miRNA320a-3p/RUNX2 signal programming mediates the transgenerational inheritance of inhibited ovarian estrogen synthesis in female offspring rats induced by prenatal dexamethasone exposure
Pharmacol Res.
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(IF 5.893)
1621. Chenye Tang, Yuntao Wu, Xiao Wang, Kean Chen, Zhiling Tang, Xiao Guo
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Hum Cell.
2021 Mar;34(2):588-597. doi: 10.1007/s13577-020-00470-3.
(IF 3.463)
1622. Tianji Lin, Nan Wu, Linhong Wang, Ruipeng Zhang, Ruolang Pan, Yun-Fang Chen
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Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR‑140‑5p‑overexpressing human dental pulp stem cells
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(IF 3.098)
1623. Bobo Yang, Wenjun Zhao, Changsheng Yin, Yu Bai, Suhua Wang, Guangwei Xing, Fang Li, Jinsong Bian, Michael Aschner, Jiyang Cai, Haifeng Shi, Rongzhu Lu
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Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS/3-MPST-H2S pathway in its astrocytic toxicity
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1624. H Guo, Y Wang, W Jia, L Liu
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MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway
Physiol Res.
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(IF 1.655)
1625. Jun Li, Cuiting Zhao, Qing Zhu, Yonghuai Wang, Guangyuan Li, Xinxin Li, Yuhong Li, Nan Wu, Chunyan Ma
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Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis
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1626. Wentao Shao, Jin Xu, Cheng Xu, Zhenkun Weng, Qian Liu, Xin Zhang, Jingjia Liang, Wenxiang Li, Yi Zhang, Zhaoyan Jiang, Aihua Gu
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Early-life perfluorooctanoic acid exposure induces obesity in male offspring and the intervention role of chlorogenic acid
Environ Pollut.
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1627. Wenjie Su, Shikai Zhu, Kai Chen, Hongji Yang, Mingwu Tian, Qiang Fu, Ganggang Shi, Shijian Feng, Dianyun Ren, Xin Jin, Chong Yang
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1628. Kunhong Zhong, Yuelong Wang, Zeng Wang, Zongliang Zhang, Shasha Zhao, Hexian Li, Jianhan Huang, Wenhao Guo, Xi Zheng, Gang Guo, Liangxue Zhou, Hui Yang, Aiping Tong
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1629. Yu Xia, Lan-Xiang Huang, Hui Chen, Juan Li, Ke-Ke Chen, Hang Hu, Fu-Bing Wang, Zhao Ding, Shi-Shang Guo
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1630. Mengmeng Yang, Yixin Cui, Jia Song, Chen Cui, Lingshu Wang, Kai Liang, Chuan Wang, Sha Sha, Qin He, Huiqing Hu, Xinghong Guo, Nan Zang, Lei Sun, Li Chen
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1631. Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
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1632. Bingbing Ma, Lin Zhang, Jiaolong Li, Tong Xing, Yun Jiang, Feng Gao
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1633. Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
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Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway
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1634. Di Meng, Hongying Pan, Youwei Chen, Jiexia Ding, Yining Dai
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1635. Bao-You Fan, Yi-Lin Pang, Wen-Xiang Li, Chen-Xi Zhao, Yan Zhang, Xu Wang, Guang-Zhi Ning, Xiao-Hong Kong, Chang Liu, Xue Yao, Shi-Qing Feng
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Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4
Neural Regen Res.
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COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes
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1637. Yigao Wu, Wei Rong, Qin Jiang, Ruiquan Wang, Huilan Huang
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1638. Yijiang Huang, Daosen Chen, Zijian Yan, Jingdi Zhan, Xinghe Xue, Xiaoyun Pan, Huachen Yu
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1639. Hui-Qing Lin, Shao-Hua Dai, Wei-Cheng Liu, Xiang Lin, Ben-Tong Yu, Shi-Biao Chen, Sheng Liu, Hua Ling, Jian Tang
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1640. Liangping Zhao, Li Wang, Daimin Zhang, Yuqi Chen, Fulu Jin
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Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model
Gene.
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1641. Xi Zhang, Yang Liu, Zhen Zhang, Juan Tan, Junjun Zhang, Hao Ou, Jie Li, Zewen Song
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1643. Yu Han, Yu Tang, Shuge Sun, Tongchol Kim, Kwangjin Ju, Sanghyok Ri, Xueying Du, Weishang Zhou, Wei Shi, Shiguo Li, Guangxu Liu
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1644. Dan Zhao, Yumei Li, Chunhong Peng, Jieru Lin, Fuxun Yu, Yichen Zhao, Xiangyan Zhang, Degang Zhao
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Biomed Pharmacother.
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Downregulating miR-96-5p promotes proliferation, migration, and invasion, and inhibits apoptosis in human trophoblast cells via targeting DDAH1
Reprod Biol.
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1646. Xiangming Xu, Jiao Nie, Lin Lu, Chao Du, Fansheng Meng, Duannuo Song
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YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer
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1647. Jingjing Li, Changmai Chen, Wei Zhang, Jing'ai Bi, Guang Yang, Erguang Li
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Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition
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1649. Li Wang, Long Wang, Dianfu Zhang, Sai Li, Jiaojiao Yin, Zhen Xu, Xuezhen Zhang
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Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain con
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1680. Yan Zhou, Xiawei Ji, Jiajing Chen, Yaoyang Fu, Juewei Huang, Rui Guo, Jinhui Zhou, Jianke Cen, Qihao Zhang, Anne Chu, Yingpeng Huang, Changlong Xu, Fangyan Wang
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Short-chain fatty acid butyrate: A novel shield against chronic gastric ulcer
Exp Ther Med.
2021 Apr;21(4):329. doi: 10.3892/etm.2021.9760.
(IF 1.785)
1681. Tong Lu, Tong Qiu, Bin Han, Yuanyong Wang, Xiao Sun, Yi Qin, Ao Liu, Nan Ge, Wenjie Jiao
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Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging
Cell Oncol (Dordr).
2021 Apr;44(2):297-310. doi: 10.1007/s13402-020-00565-x.
1682. Yunlin Ge, Shuchen Ding, Jiangbiao Feng, Jiangdong Du, Zenghui Gu
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Diosgenin inhibits Wnt/β-catenin pathway to regulate the proliferation and differentiation of MG-63 cells
Cytotechnology.
2021 Apr;73(2):169-178. doi: 10.1007/s10616-021-00454-7.
(IF 1.777)
1683. Yu-Shuai Wang, Wei-Han Yang, Wei Gao, Lu Zhang, Fang Wei, Hang Liu, Shu-Ya Wang, Ying-Ying Li, Wei-Man Zhao, Tao Ma, Qingqing Wang
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Combination and efficiency: preparation of dissolving microneedles array loaded with two active ingredients and its anti-pigmentation effects on guinea pigs
Eur J Pharm Sci.
2021 May 1;160:105749. doi: 10.1016/j.ejps.2021.105749.
(IF 3.616)
1684. Qingbiao Xu, Mingyang Hu, Min Li, Jinxiu Hou, Xianghua Zhang, Ya Gao, Bahram Chachar, Xiang Li
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Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota
Oxid Med Cell Longev.
2021 May 8;2021:5543003. doi: 10.1155/2021/5543003.
(IF 5.076)
1685. Kun-Yi Li, Xiao-Jiao Xiang, Li Song, Jian Chen, Biao Luo, Qi-Xin Wen, Bi-Rou Zhong, Gui-Feng Zhou, Xiao-Juan Deng, Yuan-Lin Ma, Li-Tian Hu, Guo-Jun Chen
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Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression
J Neurochem.
2021 May;157(4):1351-1365. doi: 10.1111/jnc.15184.
(IF 4.066)
1686. Bi-Rou Zhong, Gui-Feng Zhou, Li Song, Qi-Xin Wen, Xiao-Juan Deng, Yuan-Lin Ma, Li-Tian Hu, Guo-Jun Chen
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TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS
FASEB J.
2021 May;35(5):e21445. doi: 10.1096/fj.202002461R.
(IF 4.966)
1687. Chao Ma, Long Teng, Ge Lin, Beibei Guo, Run Zhuo, Xiaowei Qian, Tuchen Guan, Ronghua Wu, Yan Liu, Mei Liu
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L-leucine promotes axonal outgrowth and regeneration via mTOR activation
FASEB J.
2021 May;35(5):e21526. doi: 10.1096/fj.202001798RR.
(IF 4.966)
1688. Qun Zhao, Yun Bi, Jing Zhong, Xiang Li, Jian Guo, Ying-Xiang Liu, Long-Rui Pan, Yan Tan, Zhang-Shuang Deng, Xian-Jun Yu
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10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation
Acta Pharmacol Sin.
2021 May;42(5):791-800. doi: 10.1038/s41401-020-0499-y.
(IF 5.064)
1689. Qinghui Jia, Haihua Zhang, Yongmei Su, Xin Liu, Jiangsong Bai, Wuying Lang, Qiumei Shi, Minshan Feng
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Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model
J Physiol Biochem.
2021 May;77(2):283-294. doi: 10.1007/s13105-021-00796-y.
(IF 2.952)
1690. Rong Jiang, Lei Han, Qianqian Gao, Jie Chao
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ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy
Environ Toxicol Pharmacol.
2021 May;84:103605. doi: 10.1016/j.etap.2021.103605.
1691. Shengwei Liu, Jingdong Liu, Yuchun Wang, Ling Deng, Sha Chen, Xuan Wang, Tianrui Zuo, Qingwen Hu, Jiangyan Rao, Qian Wang, Zhi Dong
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Differentially expressed genes induced by β-caryophyllene in a rat model of cerebral ischemia-reperfusion injury
Life Sci.
2021 May 15;273:119293. doi: 10.1016/j.lfs.2021.119293.
(IF 3.647)
1692. Sheng Chang, Yang Cao
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Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells
Neuroreport.
2021 May 19;32(8):672-677. doi: 10.1097/WNR.0000000000001632.
(IF 1.394)
1693. Xupeng Mu, Meng Zhang, Anhui Wei, Fei Yin, Yan Wang, Kebang Hu, Jinlan Jiang
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Doxorubicin and PD-L1 siRNA co-delivery with stem cell membrane-coated polydopamine nanoparticles for the targeted chemoimmunotherapy of PCa bone metastases
Nanoscale.
2021 May 21;13(19):8998-9008. doi: 10.1039/d0nr08024a.
(IF 6.895)
1694. Bing Zou, Tieqiu Huang, Dan Wu, Xiaomin Hu, Linghui Xiao, Chenxi Wang, Hongzhou Zhang, Jian Xiang, Chenkai Hu, Qinghua Wu, Tao Wu
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Knockdown of ZFAS1 improved the cardiac function of myocardial infarction rats via regulating Wnt/β-catenin signaling pathway
Aging (Albany NY).
2021 May 5;13(9):12919-12928. doi: 10.18632/aging.202961.
1695. Jin-Jin Zhu, Bin-Yuan Yu, Xiao-Kai Huang, Min-Zhi He, Bin-Wen Chen, Ting-Ting Chen, Huang-Yi Fang, Shang-Qin Chen, Xiao-Qin Fu, Pei-Jun Li, Zhen-Lang Lin, Jiang-Hu Zhu
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Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation
Oxid Med Cell Longev.
2021 May 8;2021:6654954. doi: 10.1155/2021/6654954.
(IF 5.076)
1696. Zejie Zuo, Fangfang Qi, Zhiwei Xing, Lifang Yuan, Yunjie Yang, Zitian He, Lihua Zhou, Zhibin Yao
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Bacille Calmette-Guérin attenuates vascular amyloid pathology and maximizes synaptic preservation in APP/PS1 mice following active amyloid-β immunotherapy
Neurobiol Aging.
2021 May;101:94-108. doi: 10.1016/j.neurobiolaging.2021.01.001.
(IF 4.347)
1697. Yuanyuan Tu, E Song, Zhenzhen Wang, Na Ji, Linling Zhu, Kun Wang, Haotian Sun, Yuting Zhang, Qiujian Zhu, Xiaojuan Liu, Manhui Zhu
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Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway
Biomed Pharmacother.
2021 May;137:111274. doi: 10.1016/j.biopha.2021.111274.
(IF 4.545)
1698. Li Wang, Dianfu Zhang, Sai Li, Long Wang, Jiaojiao Yin, Zhen Xu, Xuezhen Zhang
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Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle
Biol Trace Elem Res.
2021 May;199(5):2000-2011. doi: 10.1007/s12011-020-02282-w.
(IF 2.639)
1699. Ying Wang, Zhiquan Yang, Kai Zhang, Yi Wan, Yu Zhou, Zhuanyi Yang
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miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy
Exp Ther Med.
2021 May;21(5):431. doi: 10.3892/etm.2021.9848.
(IF 1.785)
1700. Lei Zhang, Shuge Ouyang, Hongbo Zhang, Mingke Qiu, Yuxin Dai, Shuqing Wang, Yang Wang, Jingmin Ou
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Graphene oxide induces dose-dependent lung injury in rats by regulating autophagy
Exp Ther Med.
2021 May;21(5):462. doi: 10.3892/etm.2021.9893.
(IF 1.785)
1701. Huiting Sun, Yichao Shi, Yuwei Shang, Xia Chen, Fei Xia
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MicroRNA‑378d inhibits Glut4 by targeting Rsbn1 in vitamin D deficient ovarian granulosa cells
Mol Med Rep.
2021 May;23(5):369. doi: 10.3892/mmr.2021.12008.
(IF 2.1)
1702. Yuqiong Chen, Su Li, Yan Zhang, Mengshen Wang, Xinyan Li, Shuang Liu, Dengyue Xu, Yandong Bao, Pengyu Jia, Nan Wu, Yao Lu, Dalin Jia
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The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics
Redox Biol.
2021 May;41:101910. doi: 10.1016/j.redox.2021.101910.
(IF 9.986)
1703. Mengyuan Cen, Wei Ouyang, Wanying Zhang, Liping Yang, Xiuhui Lin, Min Dai, Huiqun Hu, Huifang Tang, Hongyun Liu, Jingyan Xia, Feng Xu
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MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism
Redox Biol.
2021 May;41:101936. doi: 10.1016/j.redox.2021.101936.
(IF 9.986)
1704. Xiaolong Sun, Xu Wang, Zhenyu Zhao, Jing Chen, Cheng Li, Gang Zhao
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Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2
Drug Dev Res.
2021 May;82(3):404-411. doi: 10.1002/ddr.21763.
1705. Qi Guo, Zejian Zhu, Jing Wang, Wei Huang, Chao Zhang, Jie Zeng, Haijian Zhao, Tianqi Qi, Weiyan Zhou, Tianjiao Zhang, Chuanbao Zhang, Fei Xiao
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Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH)
Clin Biochem.
2021 May;91:45-51. doi: 10.1016/j.clinbiochem.2021.02.002.
(IF 2.573)
1706. Yin Li, Hao Sheng, Feng Ma, Qiang Wu, Jianfang Huang, Qiang Chen, Lianghe Sheng, Xinghai Zhu, Xiaoxi Zhu, Meng Xu
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RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling
Cell Death Dis.
2021 May 13;12(5):479. doi: 10.1038/s41419-021-03763-z.
(IF 6.304)
1707. Shengqiang Li, Zhen Lei, Meng Zhao, Yonghao Hou, Di Wang, Xingli Xu, Xiaowen Lin, Jingxin Li, Shuhai Tang, Jingui Yu, Tao Meng
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Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway
Front Pharmacol.
2021 May 13;12:655726. doi: 10.3389/fphar.2021.655726.
(IF 4.225)
1708. Meixuan Chen, Shuo Wu, Bing Shen, Qingquan Fan, Ran Zhang, Yu Zhou, Pingping Zhang, Liecheng Wang, Lesha Zhang
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Activation of the δ opioid receptor relieves cerebral ischemic injury in rats via EGFR transactivation
Life Sci.
2021 May 15;273:119292. doi: 10.1016/j.lfs.2021.119292.
(IF 3.647)
1709. Liu Li, Li Yang, Feng Yang, Xin-Lan Zhao, Shengjiang Xue, Fang-Hua Gong
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Ginkgo biloba Extract 50 (GBE50) Ameliorates Insulin Resistance, Hepatic Steatosis and Liver Injury in High Fat Diet-Fed Mice
J Inflamm Res.
2021 May 17;14:1959-1971. doi: 10.2147/JIR.S302934.
1710. Fanxing Meng, Jiayi Qiu, Houjie Chen, Xiaojun Shi, Meifang Yin, Meishu Zhu, Guang Yang
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Dietary supplementation with N-3 polyunsaturated fatty acid-enriched fish oil promotes wound healing after ultraviolet B-induced sunburn in mice
Food Sci Nutr.
2021 May 17;9(7):3693-3700. doi: 10.1002/fsn3.2330.
(IF 1.797)
1711. Ke Wu, Xinyi Zheng, Zhixian Yao, Zhong Zheng, Wenjie Huang, Xingyu Mu, Feng Sun, Zhihong Liu, Junhua Zheng
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Accumulation of CD45RO+CD8+ T cells is a diagnostic and prognostic biomarker for clear cell renal cell carcinoma
Aging (Albany NY).
2021 May 19;13(10):14304-14321. doi: 10.18632/aging.203045.
1712. Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
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C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase
Free Radic Biol Med.
2021 May 1;167:181-192. doi: 10.1016/j.freeradbiomed.2021.02.022.
1713. Xiaolei Hu, Ling Xu, Xuewei Fu, Jiao Huang, Ping Ji, Zhiwei Zhang, Feng Deng, Xiaomian Wu
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The TiO2-μ implant residual is more toxic than the Al2O3-n implant residual via blocking LAP and inducing macrophage polarization
Nanoscale.
2021 May 20;13(19):8976-8990. doi: 10.1039/d1nr00696g.
(IF 6.895)
1714. Ming Deng, Ping Xie, Zhonghui Chen, Yan Zhou, Junqi Liu, Jianghua Ming, Jianwei Yang
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Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats
Gene.
2021 May 20;781:145528. doi: 10.1016/j.gene.2021.145528.
(IF 2.984)
1715. Ruye Ma, Dandan Yu, Yu Peng, Hongfei Yi, Yingcong Wang, Taofang Cheng, Bingqing Shi, Guang Yang, Weiming Lai, Xiaosong Wu, Ye Lu, Jumei Shi
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Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells
Acta Biochim Biophys Sin (Shanghai).
2021 May 21;53(6):775-783. doi: 10.1093/abbs/gmab042.
1716. Dongrui Zhou, Kai Cen, Wei Liu, Fengzhi Liu, Ruijia Liu, Yikun Sun, Yizhou Zhao, Jingling Chang, Lingqun Zhu
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Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo
J Ethnopharmacol.
2021 May 23;272:113943. doi: 10.1016/j.jep.2021.113943.
(IF 3.69)
1717. Duo Wen, Wan-Lin Liu, Zhong-Wu Lu, Yi-Ming Cao, Qing-Hai Ji, Wen-Jun Wei
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SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway
Front Oncol.
2021 May 4;11:647034. doi: 10.3389/fonc.2021.647034.
(IF 4.848)
1718. Jiaying Wang, Conghui Wang, Yang Li, Mingyue Li, Tingjia Zhu, Zhangjin Shen, Hui Wang, Weiguo Lv, Xinyu Wang, Xiaodong Cheng, Xing Xie
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Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer
Clin Transl Med.
2021 May;11(5):e425. doi: 10.1002/ctm2.425.
1719. Pengfei Zhao, Chaofei Wang, Jun Ding, Chengfeng Zhao, Yingjun Xia, Yanli Hu, Li Zhang, Yanqin Zhou, Junlong Zhao, Rui Fang
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Evaluation of immunoprotective effects of recombinant protein and DNA vaccine based on Eimeria tenella surface antigen 16 and 22 in vivo
Parasitol Res.
2021 May;120(5):1861-1871. doi: 10.1007/s00436-021-07105-y.
(IF 1.641)
1720. Yixuan Wu, Zhigang Jiao, Zhiting Wan, Shaogang Qu
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Role of autophagy and oxidative stress to astrocytes in fenpropathrin-induced Parkinson-like damage
Neurochem Int.
2021 May;145:105000. doi: 10.1016/j.neuint.2021.105000.
(IF 3.881)
1721. Xianming Chen, Yulin Zhang, Sen Zhang, Aiming Wang, Quanyin Du, Ziming Wang
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Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway
Exp Ther Med.
2021 May;21(5):443. doi: 10.3892/etm.2021.9883.
(IF 1.785)
1722. Feifei Shao, Lingmin Zhou, Yu Zhang, Hongping Chen, Yu Zhang, Zhihui Guan
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Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression
In Vitro Cell Dev Biol Anim.
2021 May;57(5):571-581. doi: 10.1007/s11626-021-00593-3.
1723. Rutao Lin, Zixu Wang, Jing Cao, Ting Gao, Yulan Dong, Yaoxing Chen
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Role of melatonin in murine "restraint stress"-induced dysfunction of colonic microbiota
J Microbiol.
2021 May;59(5):500-512. doi: 10.1007/s12275-021-0305-7.
(IF 2.845)
1724. Mengzhu Zheng, Junfeng Huo, Xiaoxia Gu, Yali Wang, Canrong Wu, Qingzhe Zhang, Wang Wang, Yang Liu, Yu Liu, Xuechen Zhou, Lixia Chen, Yirong Zhou, Hua Li
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Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP
J Med Chem.
2021 Jun 10;64(11):7839-7852. doi: 10.1021/acs.jmedchem.1c00649.
(IF 6.205)
1725. Wei Zhang, Donge Tang, Liewen Lin, Tingting Fan, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Yong Xu, Yong Dai
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Integrative multiplatform-based molecular profiling of human colorectal cancer reveals proteogenomic alterations underlying mitochondrial inactivation
Am J Cancer Res.
2021 Jun 15;11(6):2893-2910.
(IF 5.177)
1726. Guanghua Yang, Chen Zeng, Yang Liu, Dongliang Li, Juanjuan Cui
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ZNRD1-AS1 knockdown alleviates malignant phenotype of retinoblastoma through miR-128-3p/BMI1 axis
Am J Transl Res.
2021 Jun 15;13(6):5866-5879.
(IF 3.375)
1727. Wei Zhang, Liewen Lin, Ligang Xia, Wanxia Cai, Weier Dai, Chang Zou, Lianghong Yin, Donge Tang, Yong Xu, Yong Dai
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Multi-omics analyses of human colorectal cancer revealed three mitochondrial genes potentially associated with poor outcomes of patients
J Transl Med.
2021 Jun 26;19(1):273. doi: 10.1186/s12967-021-02939-7.
(IF 4.124)
1728. Zili Lei, Huijuan Wu, Yanhong Yang, Qing Hu, Yuting Lei, Wanwan Liu, Ya Nie, Lanxiang Yang, Xueying Zhang, Changyuan Yang, Ting Lin, Fengxue Tong, Jiamin Zhu, Jiao Guo
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Ovariectomy Impaired Hepatic Glucose and Lipid Homeostasis and Altered the Gut Microbiota in Mice With Different Diets
Front Endocrinol (Lausanne).
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1729. Yan Hu, Bing Wang, Ke Yi, Qingjun Lei, Guanghui Wang, Xiaohui Xu
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IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
Cancer Cell Int.
2021 Jun 3;21(1):290. doi: 10.1186/s12935-021-01997-7.
(IF 4.175)
1730. Liqiang Qi, Bo Sun, Beibei Yang, Su Lu
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circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326
Onco Targets Ther.
2021 Jun 9;14:3671-3685. doi: 10.2147/OTT.S299190.
1731. Shaojian Chen, Zhihuan Luo, Xiaguang Chen
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Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis
Cell Cycle.
2021 Jun;20(12):1107-1121. doi: 10.1080/15384101.2021.1916272.
(IF 3.699)
1732. Yuan Gao, Xinjia Zhou, Yan Zhou, Wei Zhang, Li Zhao
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Chrysene accelerates the proceeding of chronic obstructive pulmonary disease with the aggravation of inflammation and apoptosis in cigarette smoke exposed mice
Hum Exp Toxicol.
2021 Jun;40(6):1031-1044. doi: 10.1177/0960327120979343.
(IF 2.067)
1733. Mingdong Yu, Chao Qin, Pei Li, Yingli Zhang, Ying Wang, Jing Zhang, Dedong Li, Huixing Wang, Yuechun Lu, Keliang Xie, Yang Yu, Yonghao Yu
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Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice
Int Immunopharmacol.
2021 Jun;95:107583. doi: 10.1016/j.intimp.2021.107583.
(IF 3.943)
1734. Qian Chai, Jiajing Miao, Meili Liu, Ziying Zhang, Ziang Meng, Weihua Wu
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Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction
Biochem Cell Biol.
2021 Jun;99(3):356-363. doi: 10.1139/bcb-2020-0491.
(IF 2.46)
1735. Hengchen Liu, Mingzhao Zhang, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui, Zhaozhu Li
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Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3
Stem Cell Res Ther.
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(IF 5.116)
1736. Xiao Liu, Ling Wang, Qunzhi Xing, Kehan Li, Jianluo Si, Xiaowu Ma, Lianjing Mao
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Sevoflurane inhibits ferroptosis: A new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury
Life Sci.
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(IF 3.647)
1737. Zongzhen Liao, Dihang Lin, Jirong Jia, Ran Cai, Yang Yu, Wensheng Li
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Innate Immune Response to Fasting and Refeeding in the Zebrafish Kidney
Biomolecules.
2021 Jun 1;11(6):825. doi: 10.3390/biom11060825.
(IF 4.082)
1738. Qiang Zheng, Yuan Zhang, Zheng Zhao, Haitao Shen, Hongyu Zhao, Min Zhao
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Isorhynchophylline ameliorates paraquat-induced acute kidney injury by attenuating oxidative stress and mitochondrial damage via regulating toll-interacting expression
Toxicol Appl Pharmacol.
2021 Jun 1;420:115521. doi: 10.1016/j.taap.2021.115521.
1739. Yun Long, Yi-Cheng Wang, Dong-Zhi Yuan, Xin-Hua Dai, Lin-Chuan Liao, Xue-Qin Zhang, Li-Xue Zhang, Yong-Dan Ma, Yi Lei, Zhi-Hui Cui, Jin-Hu Zhang, Li Nie, Li-Min Yue
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GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation
Front Physiol.
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1740. Jianqing Jiang, Mingsong Cai
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Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte
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2021 Jun 28;31(6):794-802. doi: 10.4014/jmb.2103.03057.
1741. Jinglin Ma, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji, Lihong Zhao
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Transcriptional Profiling of Aflatoxin B1-Induced Oxidative Stress and Inflammatory Response in Macrophages
Toxins (Basel).
2021 Jun 4;13(6):401. doi: 10.3390/toxins13060401.
1742. Qian Qu, Yan Li, Zhenyan Zhang, Hengzheng Cui, Qianqiu Zhao, Wanyue Liu, Tao Lu, Haifeng Qian
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Effects of S-metolachlor on wheat (Triticum aestivum L.) seedling root exudates and the rhizosphere microbiome
J Hazard Mater.
2021 Jun 5;411:125137. doi: 10.1016/j.jhazmat.2021.125137.
(IF 9.038)
1743. Huiqiong Jiang, Jiaren Lv
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MicroRNA-301a-3p increases oxidative stress, inflammation and apoptosis in ox-LDL-induced HUVECs by targeting KLF7
Exp Ther Med.
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(IF 1.785)
1744. Tengfei Zhang, Danjie Guo, Weiping Zheng, Qunyun Dai
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Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats
Mol Med Rep.
2021 Jun;23(6):456. doi: 10.3892/mmr.2021.12095.
(IF 2.1)
1745. Yong Xu, Xiang Li, Hailun Li, Lili Zhong, Yongtao Lin, Juan Xie, Donghui Zheng
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Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R
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(IF 4.486)
1746. Jing Chen, Wenbin Shi, Yan Xu, Huaming Zhang, Bo Chen
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Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling pathway
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Circulatory cadmium positively correlates with epithelial-mesenchymal transition in patients with chronic obstructive pulmonary disease
Ecotoxicol Environ Saf.
2021 Jun 1;215:112164. doi: 10.1016/j.ecoenv.2021.112164.
1748. Qingyun Zheng, Tianyi Wang, Xiangying Zhu, Xiao Tian, Chen Zhong, Guolin Chang, Gai Ran, Yilin Xie, Bing Zhao, Liqing Zhu, Chen Ling
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Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo
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1749. Yaping Jiang, Xin Zhang, Xiaoyan Zhang, Kun Zhao, Jing Zhang, Chuanxi Yang, Yihui Chen
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Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing
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2021 Jun 25;9:670528. doi: 10.3389/fcell.2021.670528.
(IF 5.201)
1750. Shuaishuai Gong, Jincheng Liu, Shiyao Wan, Weiwei Yang, Yuanyuan Zhang, Boyang Yu, Fang Li, Junping Kou
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1752. Bin Zhai, Xiaohong Li, Cheng Lin, Peiyu Yan, Qun Zhao, Erchao Li
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1754. Yubo Wang, Yuanyuan Zhou, Sheng Cao, Yue Sun, Zhiqiang Dong, Chen Li, Haoran Wang, Yuhong Yao, Haiyan Yu, Xiangyi Song, Ming Li, Jiefu Wang, Mingming Wei, Guang Yang, Cheng Yang
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1756. Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi
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1774. Yaoyao Hou, Yingjun Fan, Xian Xia, Jicheng Pan, Jianjun Hou, Xixia Liu, Xinpeng Chen
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A novel small-molecule fatty acid synthase inhibitor with antitumor activity by cell cycle arrest and cell division inhibition
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1789. Lei Zhang, Dingyu Hao, Pengyi Ma, Boyuan Ma, Jia Qin, Guangyuan Tian, Zihao Liu, Xianhu Zhou
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1790. Dezhi Li, Min Yan, Fengfei Sun, Junmei Song, Xingsheng Hu, Sijia Yu, Lina Tang, Shishan Deng
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1791. Jinxiu Chu, Jian Wang, Lijuan Cui, Shuai Liu, Nina An, Jian Han, Xiaohang Che, Chunfu Wu, Jingyu Yang
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1792. Jiujiao Gao, Peng Chu, Caigang Liu, Zhaolin Sun, Quentin Liu, Yongliang Yang
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Discovery and biological evaluation of a small-molecule inhibitor of CRM1 that suppresses the growth of triple-negative breast cancer cells
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1793. Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xia
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Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts
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Novel Nanoliposome Codelivered DHA and Anthocyanidin: Characterization, In Vitro Infant Digestibility, and Improved Cell Uptake
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Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice
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Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors
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1822. Lan Jiang, Qianhong Yang, Jianjun Gao, Jiahong Yang, Jiaqi He, Hong Xin, Xuemei Zhang
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BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway
Mol Cells.
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(IF 4.081)
1823. Qian Zheng, Pengfei Li, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong, Feng Li
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Theranostics.
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(IF 8.579)
1824. Chen Yu, Hengchang Zang, Cui Yang, Dong Liang, Shuang Quan, Danyang Li, Yanni Li, Qin Dong, Fengshan Wang, Lian Li
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Study of chondroitin sulfate E oligosaccharide as a promising complement C5 inhibitor for osteoarthritis alleviation
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1825. Wei Wang, Rui Wang, Zhijun Jiang, Haonan Li, Zemeng Zhu, Arslan Khalid, Dexiang Liu, Fang Pan
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Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats
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(IF 4.066)
1826. Ping Wang, Xinwei Hao, Xiaohan Li, Yizhi Yan, Wenxiu Tian, Lin Xiao, Zhenming Wang, Junhong Dong
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(IF 4.486)
1827. Ye Li, Xin Wei, Shu-Li Liu, Ying Zhao, Si Jin, Xiao-Yan Yang
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Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3
Phytother Res.
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(IF 4.087)
1828. Xu-Peng Wang, Wei-Chao Zheng, Yang Bai, Yan Li, Yue Xin, Jing-Zhou Wang, Yu-Lin Chang, Li-Min Zhang
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Inflammation.
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(IF 3.212)
1829. Jing Sun, Xiang Zhou, Jusheng Wu, Renjie Xiao, Yong Chen, Yimei Lu, Haili Lang
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Ligustilide enhances hippocampal neural stem cells activation to restore cognitive function in the context of postoperative cognitive dysfunction
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1830. Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
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1831. Hong Zhang, Mengyi Chi, Linlin Chen, Xipeng Sun, Lili Wan, Quanjun Yang, Cheng Guo
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Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway
Phytother Res.
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(IF 4.087)
1832. Runqing Huang, Jianxia Li, Yang Fu, Yanhong Deng
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(IF 3.297)
1833. Hao Li, Wenchao Xu, Xiaming Liu, Tao Wang, Shaogang Wang, Jihong Liu, Hongyang Jiang
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JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis
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1834. Gui-Lin Jin, Li-Mian Hong, Hai-Ping Liu, Rong-Cai Yue, Zu-Cheng Shen, Jian Yang, Ying Xu, Hui-Hui Huang, Yi Li, Bo-Jun Xiong, Yan-Ping Su, Chang-Xi Yu
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Koumine modulates spinal microglial M1 polarization and the inflammatory response through the Notch-RBP-Jκ signaling pathway, ameliorating diabetic neuropathic pain in rats
Phytomedicine.
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1835. Qingman Li, Lijie Zhu, Fangqing Niu, Qingmin Li, Che Wang, Honghui Yang, Chuanyu Gao
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Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206
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(IF 2.202)
1837. Abdoulaye Issotina Zibrila, Zheng Wang, Md Ahasan Ali, James Ampofo Osei, Yuyao Sun, Salman Zafar, Kaili Liu, Chunfang Li, Yuming Kang, Jinjun Liu
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Pyridostigmine ameliorates preeclamptic features in pregnant rats by inhibiting tumour necrosis factor-α synthetsis and antagonizing tumour necrosis factor-α-related effects
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1838. Yiliang Wang, Weisheng Luo, Lianzhou Huang, Ji Xiao, Xiaowei Song, Feng Li, Yuying Ma, Xiaohui Wang, Fujun Jin, Ping Liu, Yexuan Zhu, Kaio Kitazato, Yifei Wang, Zhe Ren
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A novel lncRNA linc-AhRA negatively regulates innate antiviral response in murine microglia upon neurotropic herpesvirus infection
Theranostics.
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(IF 8.579)
1839. Ming Chang, Dan Zhu, Yanjiang Chen, Weiquan Zhang, Xi Liu, Xiao-Lan Li, Zhiping Cheng, Zhiheng Su, Jian Zhang, Yi Lu, Hongwei Guo
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Total Flavonoids of Litchi Seed Attenuate Prostate Cancer Progression Via Inhibiting AKT/mTOR and NF-kB Signaling Pathways
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Apigenin acts as a partial agonist action at estrogen receptors in vivo
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1842. Rong Fan, Jidong Sui, Xuepeng Dong, Biao Jing, Zhenming Gao
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Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis
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1843. Xuejun Dai, Yanyu Guan, Zhongzi Zhang, Ying Xiong, Chengwei Liu, Haifeng Li, Bailian Liu
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1845. Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi
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A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism
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1848. Xing Xie, Fei Hao, Rong Chen, Jingjing Wang, Yanna Wei, Jin Liu, Haiyan Wang, Zhenzhen Zhang, Yun Bai, Guoqing Shao, Qiyan Xiong, Zhixin Feng
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Nicotinamide Adenine Dinucleotide-Dependent Flavin Oxidoreductase of Mycoplasma hyopneumoniae Functions as a Potential Novel Virulence Factor and Not Only as a Metabolic Enzyme
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Effect of γ-aminobutyric Acid on Phenolics Metabolism in Barley Seedlings under Low NaCl Treatment
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1853. Tao Li, Bin Fu, Xin Zhang, Yunjiang Zhou, Mengdi Yang, Mengran Cao, Yaxin Chen, Yingying Tan, Rong Hu
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1855. Yue Xiong, Xiaochuan Cui, Yanjun Zhou, Gaoshang Chai, Xiufeng Jiang, Guizhi Ge, Yue Wang, Hongxu Sun, Huilian Che, Yunjuan Nie, Peng Zhao
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1856. Erping Xu, Baoying Wang, Shuaifei Lu, Changjing Zhang, Leilei Zhu, Xueying Liu, Ming Bai, Yucheng Li
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Tandem mass tag-based quantitative proteomic analysis of the liver reveals potential protein targets of Xiaochaihutang in CUMS model of depression
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1858. Bo Liao, Mengtong Guan, Qiaoyan Tan, Gailan Wang, Ruobin Zhang, Junlan Huang, Mi Liu, Hong Chen, Kaiting Li, Dingqun Bai, Ying Zhu
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1860. Tanjing Song, Qingli Zou, Yingying Yan, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Haigang Liu, Borui Tang, Lidong Sun
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1861. Chengyuan Yang, Cheng Gao, Naicheng Liu, Yitong Zhu, Xu Zhu, Xinlin Su, Qin Zhang, Yanglin Wu, Chenhui Zhang, Ang Liu, Weifeng Lin, Luyang Tao, Huilin Yang, Jun Lin
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1862. Shuangqi Fan, Keke Wu, Mingqiu Zhao, Jin Yuan, Shengming Ma, Erpeng Zhu, Yuming Chen, Hongxing Ding, Lin Yi, Jinding Chen
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LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection
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1863. Han Lu, Hui-Li Yang, Wen-Jie Zhou, Zhen-Zhen Lai, Xue-Min Qiu, Qiang Fu, Jian-Yuan Zhao, Jian Wang, Da-Jin Li, Ming-Qing Li
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1864. Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
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Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: Role of oxidative stress, neuroinflammation, autophagy and apoptosis
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Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway
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1866. Nian Zhou, Bing Yan, Jing Ma, Hongchao Jiang, Li Li, Haoyu Tang, Fengming Ji, Zhigang Yao
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1867. Wen-Juan Wang, Xia Jiang, Chang-Chun Gao, Zhi-Wei Chen
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MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway
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【实验技巧】BCA 法蛋白定量 - 实验方法 - 丁香通
【实验技巧】BCA 法蛋白定量 - 实验方法 - 丁香通
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首页 实验方法 蛋白质技术 蛋白质含量测定 【实验技巧】BCA 法蛋白定量
【实验技巧】BCA 法蛋白定量
【实验技巧】BCA 法蛋白定量
来源: &英文特</a&>
84836 阅读
【实验技巧】BCA 法蛋白定量有问题?丁香实验库全新大升级,10000+ 实验方法任你选
前往丁香实验
BCA 蛋白定量法是实验室常用的蛋白质定量方法。Invent 所有蛋白提取试剂盒提取的蛋白均可使用 BCA 法进行定量!那么今天小编就手把手的教大家该如何用 BCA 来定量!
BCA 法原理
碱性条件下,蛋白将 Cu2+还原为 Cu+,Cu+与 BCA 试剂相互作用形成紫色的络合物,该水溶性的复合物在 562nm 处显示强烈的吸光性,吸光度和蛋白浓度在广泛范围内有良好的线性关系,因此根据吸光值可以推算出蛋白浓度。
实验操作具体步骤
1. 梯度稀释牛血清白蛋白(BSA)标准品(具体操作按试剂盒中说明操作)
2. 制备 BCA 工作液(具体操作按说明书进行)
3. 将各个稀释浓度的蛋白质标准品和待测蛋白质样品加入到微孔板或试管中,分别加入 BCA 工作液(比例参照试剂盒说明书)混匀。
4. 密封后,37℃ 保温 30-60 min
5. 冷却到室温,以空白为对照,测量样品在 562nm 或该波长附近的吸光值
6. 将各个标准品和待测蛋白质样品在 562nm 处的吸光值减去空白标准品在 562nm 处的平均吸光值。
浓度计算步骤
1. 输入相对应的标准曲线值和相应的蛋白样品值。(图中所示均为举例说明,具体数据参照自己的实验结果)选定标准曲线的 OD 值和标准品蛋白浓度。
2. 点击表头上的插入-图表-XY 散点图,点击确定。
3. 完成后会弹出一个图表,点击图表里面的散点,右键添加趋势曲线。
4. 完成后弹出设置趋势线格式,点击选勾最底下显示公式(E)以及显示 R 平方值。则在图表标题中显示出公式和 R2 值来。一般 R2 值越接近 1 代表你的标准曲线做得越好,根据标准曲线带入的样品 OD 值测出的蛋白浓度也越准确。R2 值越接近 1 越好,一般要求为 0.99 几左右。
5. 将样品 OD 值代入标准曲线的公式中,推导即得到待测样品蛋白的浓度。以 C1 蛋白样品 OD 值为例,按照图中模式代入公式,点击 enter 即为终结果。
图片来源:均为英文特公司制作,版权归英文特所属!
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chengxue727
为什么同一批次提取蛋白跑出的条带不一致 做这个实验的时,我同一批次提取的蛋白,胶跑出的条带都不一致,这是什么原因呢? 43 评论
jianchi20
WB 敷牛奶需要的时间 Western Blot 实验时敷牛奶大概多久?一定要过夜吗 42 评论
grass010
WB发光结果异常 我做WB也不算是新手,自己觉得整个过程也没有什么明显的问题,可是最后发光的时候内参整个是晕开的,分子还连成了一条线,之前没出现过这种情况,所以想请大家帮忙分析下,是胶的问题,蛋白的问题,还是什么别的,谢啦! 28 评论
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BCA(水溶性复合物)_百度百科
水溶性复合物)_百度百科 网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心BCA是一个多义词,请在下列义项上选择浏览(共6个义项)添加义项收藏查看我的收藏0有用+10BCA播报讨论上传视频水溶性复合物BCA(bicinchoninic acid)钠盐是一种稳定的水溶性复合物,可与Cu2+高度特异性结合,产生紫色复合物。中文名聚氰基丙烯酸正丁酯外文名butyleyanoacrylate,BCA别 名2,2-联喹啉-4,4-二甲酸二钠化学式C20H10N2Na2O4 · xH2O分子量388.28CAS登录号979-88-4目录1化学性质2质量标准3应用范围化学性质播报编辑淡黄色粉末、有吸湿性,溶解于水或者乙醇。质量标准播报编辑外观Appearance淡黄色粉末红外光谱鉴别Infrared spectrometry<符合纯度Purity≥98.0% (HPLC)水分Moistrue≤4%铁Iron(Fe)<5PPM重金属Heavy Metals<5PPM灼烧残渣Residue On Ignition≤0.1%水溶性试验Solubility500mg/ml水摩尔吸收系数Molar Absorptivity3.74*104(氧化产物)应用范围播报编辑该复合物在562 nm处有最大吸光值,并与蛋白浓度成正比。以BCA为标准品求得标准曲线,进而计算未知蛋白样品的浓度,故BCA常用于蛋白定量检测,是蛋白定量试剂的重要原料。 [1]新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号 京公网安备110000020000BCA蛋白浓度检测_百度百科
白浓度检测_百度百科 网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心BCA蛋白浓度检测播报讨论上传视频检测实验收藏查看我的收藏0有用+10BCA蛋白浓度检测是一个实验,是根据吸光值可以推算出蛋白浓度.碱性条件下,蛋白将Cu2+还原为Cu+, Cu+与BCA试剂形成紫颜色的络合物,两分子BCA螯合一个Cu+。将该水溶性复合物在562nm处的吸收值,与标准曲线对比,即可计算待测蛋白的浓度。常用浓度的去垢剂SDS,Triton X-100,Tween不影响检测结果,但受螯合剂(EDTA,EGTA)、还原剂(DTT,巯基乙醇)和脂类的影响。实验中,若发现样品稀释液或裂解液本身背景值较高,可试用Bradford蛋白浓度测定试剂盒。中文名BCA蛋白浓度检测外文名BCA assay实验试剂BCA试剂,标准蛋白质溶液实验操作绘制标准曲线试验方法根据吸光值可以推算出蛋白浓度。目录1简介2实验试剂3实验操作简介播报编辑二价铜离子在碱性的条件下,可以被蛋白质还原成一价铜离子,一价铜离子和独特的BCA Solution A(含有BCA)相互作用产生敏感的颜色反应。两分子的BCA螯合一个铜离子,形成紫色的反应复合物。该水溶性的复合物在562nm处显示强烈的吸光性,吸光度和蛋白浓度在广泛范围内有良好的线性关系,因此根据吸光值可以推算出蛋白浓度。测定方法:实验试剂播报编辑(1) BCA试剂的配制① 试剂A,1L:分别称取10g BCA (1%),20g Na2CO3·H2O(2%),1.6g Na2C4H4O6·2H2O(0.16%),4g NaOH (0.4%) ,9.5g NaHCO3(0.95%) ,加水至1L,用NaOH或固体NaHCO3调节pH值至11.25。②试剂B,50ml:取2g CuSO4·5H2O (4%),加蒸馏水至50ml。③BCA试剂:取50份试剂A与1份试剂B混合均匀。此试剂可稳定一周。(2)标准蛋白质溶液:称取0.5g牛血清白蛋白,溶于蒸馏水中并定容至100ml,制成5mg/ml的溶液。用时稀释十倍。实验操作播报编辑绘制标准曲线:取96孔酶标板,按下表加入试剂。管号12345678标准蛋白溶液(μl)蒸馏水(μl)BCA试剂(μl)蛋白质浓度(mg/ml)02020001192000.0252182000.054162000.18122000.21282000.31642000.42002000.5上述试剂加完后,准确吸取20μl样品溶液于酶标孔中,加入BCA试剂200μl,轻摇,于37℃保温30-60min,冷却至室温后,以空白为对照,在酶标仪上562nm处比色,以牛血清白蛋白含量为横坐标,以吸光值为纵坐标,绘制标准曲线。以标准曲线空白为对照,根据样品的吸光值从标准曲线上查出样品的蛋白质含量。新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号 京公网安备110000020000蛋白质定量BCA法原理/实验流程/优缺点-钟鼎生物
蛋白质定量BCA法原理/实验流程/优缺点-钟鼎生物
BCA法原理/优缺点/实验流程
◎当前位置:首页>>技术服务>>重组蛋白表达服务>>BCA法实验指南
BCA法(bicinchoninic acid)是一种常用的测蛋白质浓度的方法,本文介绍了BCA法蛋白质定量的原理,优缺点,以及BCA的实验流程。
1.BCA法原理
BCA法基于双缩脲原理,碱性条件下蛋白质将Cu2+还原成Cu+,BCA鳌合Cu+作为显色剂,产生蓝紫色并在562nm有吸收峰,单价Cu+与蛋白质呈剂量相关性。可以根据待测蛋白在562nm处的吸光度计算待测蛋白浓度。
2.BCA法优缺点分析
优点
缺点
①.灵敏度高,检测浓度下限达到25μg/ml,最小检测蛋白量达到0.5μg;②.不易受一般浓度去污剂的干扰,抗干扰能力强。③.在20-2000μg/ml浓度范围内有良好的线性关系。
①.可受螯合剂,高浓度还原剂的影响。
3.BCA法实验流程
①标准曲线的绘制:取一块酶标板,按下表加入试剂。
孔号
蛋白标准溶液(μL)
去离子水(μL)
对应蛋白含量(μg)
0
0
20
0
1
1
19
0.5
2
2
18
1.0
3
4
16
2.0
4
8
12
4.0
5
12
8
6.0
6
16
4
8.0
7
20
0
10.0
②根据样品数量,按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液,充分混匀。
③各孔加入200μL BCA工作液。
④把酶标板放在振荡器上振荡30s,37℃放置30min,然后在562nm下比色测定。以蛋白含量(μg)为横坐标,吸光值为纵坐标,绘出标准曲线。
⑤稀释待测样品至合适浓度,使样品稀释液总体积为20μL,加入BCA工作液200μL,充分混匀,37℃放置30min后,以标准曲线0号管做参比,在562nm波长下比色,记录吸光值。
⑥根据所测样品的吸光值,利用计算公式计算出蛋白样品的实际浓度(单位:μg/μL)。
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